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Keywords: Mitochondria
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Journal Articles
Journal: Development
Development (2022) 149 (23): dev200870.
Published: 29 November 2022
... established, recent evidence has also highlighted mitochondria as central players in NSC behaviour and fate decisions. Many aspects of cellular metabolism and mitochondrial biology change during NSC transitions, interact with signalling pathways and affect the activity of chromatin-modifying enzymes...
Journal Articles
Journal: Development
Development (2022) 149 (15): dev200891.
Published: 10 August 2022
... muscle Developmental plasticity Juvenile hormone sensitivity TCA cycle Mitochondria Acyrthosiphon pisum Northwest A and F University http://dx.doi.org/10.13039/501100007548 National Natural Science Foundation of China http://dx.doi.org/10.13039/501100001809 31471819...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (20): dev199914.
Published: 6 July 2022
... and an increase in the astrocytic marker GFAP. PDH mutant shows a significant increase in the S100β+ population. Data are shown as mean±s.e.m. * P <0.05; ** P <0.01; *** P <0.001; **** P <0.0001 (ordinary one-way ANOVA with a Dunnett's multiple comparisons test post-hoc). Mitochondria...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (17): dev199477.
Published: 6 September 2021
...Margherita Peron; Alberto Dinarello; Giacomo Meneghetti; Laura Martorano; Riccardo M. Betto; Nicola Facchinello; Annachiara Tesoriere; Natascia Tiso; Graziano Martello; Francesco Argenton ABSTRACT The STAT3 transcription factor, acting both in the nucleus and mitochondria, maintains embryonic stem...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (8): dev197343.
Published: 26 April 2021
.... ( 2010a ). Mislocalization of mitochondria and compromised renal function and oxidative stress resistance in Drosophila SesB mutants . Physiol. Genomics 41 , 33 - 41 . 10.1152/physiolgenomics.00147.2009 Terhzaz , S. , Finlayson , A. J. , Stirrat , L. , Yang , J...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (8): dev197558.
Published: 16 April 2021
... phenotype, and impaired fertility. PRSS50 LRWD1 NFκB IκB AKAP4 SEPT12 H3K9me3 Infertility MMAF Mitochondria Centrosome Midpiece Sperm tail One in ten men of reproductive age are infertile ( Forti and Krausz, 1998 ; Sharlip et al., 2002 ; Datta et al., 2016 ). Although 25...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (8): dev199026.
Published: 16 April 2021
... complex Znhit1 H2A.Z Mitochondria Metabolism Heart development Mouse In mammals, the heart is the first organ to develop in order to establish a functional circulatory system that is vital for organismal growth during embryogenesis ( Cui et al., 2018 ; Waardenberg et al., 2014 ). Heart...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (11): dev175786.
Published: 11 June 2020
... phenotypes of interest. Table 2. Tools to analyze and quantify differential circRNA abundances in RNA-sequencing experiments Mitochondria are intracellular organelles primarily known for generating ATP. Mitochondria are also important players in a number of signaling pathways...
Journal Articles
Journal: Development
Development (2020) 147 (10): dev188714.
Published: 26 May 2020
...Agnes Cheong; Danielle Archambault; Rinat Degani; Elizabeth Iverson; Kimberly D. Tremblay; Jesse Mager ABSTRACT Mitochondria are essential for energy production and although they have their own genome, many nuclear-encoded mitochondrial ribosomal proteins (MRPs) are required for proper function...
Journal Articles
In collection:
Neural development
Journal: Development
Development (2019) 146 (20): dev182857.
Published: 24 October 2019
... stage of forebrain specification. Progenitors showed striking mitochondrial structural changes transitioning from glycolytic cristae at E8.5, to more traditional mitochondria at E10.5. Accordingly, glucose use shifted in progenitors such that E8.5 progenitors relied on glycolysis, and after NTC...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (18): dev168609.
Published: 26 September 2018
... composition of the regenerating myocardium by reducing mitochondrial dysfunction and preventing fat accumulation. Mouse Myocardial infarction Cardiac regeneration Mitochondria Adipogenesis Previous work has revealed that modifications of molecular pathways, such as the Hippo pathway, can...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (8): dev143420.
Published: 13 April 2018
...Hongbo Zhang; Keir J. Menzies; Johan Auwerx ABSTRACT The importance of mitochondria in energy metabolism, signal transduction and aging in post-mitotic tissues has been well established. Recently, the crucial role of mitochondrial-linked signaling in stem cell function has come to light...
Journal Articles
Journal: Development
Development (2017) 144 (18): 3193–3198.
Published: 15 September 2017
... by The Company of Biologists Ltd 2017 Summary: This Meeting Review of the 2017 EMBO/EMBL Symposium ‘Metabolism in Time and Space’ summarizes recent findings that emphasize how metabolism and developmental biology are inseparably linked in animals and plants. Metabolism Mitochondria Aerobic...
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2017) 144 (13): 2490–2503.
Published: 1 July 2017
... production, which was further enhanced by the incompatibility with simw 501 mitochondria. Mito-nuclear incompatibility also resulted in aberrant egg morphology and a maternal-effect on embryonic chromosome segregation and survival, which was completely dependent on the temperature and mito-nuclear genotype...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (12): 2175–2186.
Published: 15 June 2017
..., where it colocalizes at myofilaments with ARX-2, a component of the Arp2/3 actin-nucleation complex. Genetic studies suggest that SMN-1 promotes Arp2/3 activity important for localizing mitochondria to I-bands. Our results support the model that VAPB homologs are circulating hormones that pattern...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (22): 4203–4213.
Published: 15 November 2016
... require the regulation of kinesin and dynein by two adaptor proteins, Milton and Miro. Recently, we found that dynein heavy chain 64C ( Dhc64C ) is the primary motor protein for both anterograde and retrograde transport of mitochondria in the Drosophila bristle. In this study, we show that a molecular...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (4): 681–691.
Published: 15 February 2015
..., indicating that maternal obesity before conception had altered the transmission of mitochondria to offspring. Treatment of the obese females with the ER stress inhibitor salubrinal or the chaperone inducer BGP-15 before ovulation increased the amount of the mitochondrial replication factors TFAM and DRP1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (22): 4206–4218.
Published: 15 November 2014
... Metabolism Mitochondria Work in the past decade has uncovered the importance of redox signaling to the biology of stem cells. ROS signal the metabolic state of stem cells and, in doing this, can impact stem cell fate. Whether ROS globally impact the stem cell epigenome is not known; however, given...
Journal Articles
Journal: Development
Development (2012) 139 (21): 4083–4093.
Published: 1 November 2012
... for correspondence ( kazuk@kochi-u.ac.jp ) Competing interests statement The authors declare no competing financial interests. 3 8 2012 © 2012. 2012 Budding Eed Mitochondria Polycomb group Senescence Tunicate P. misakiensis All eukaryotes inevitably undergo senescence...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (16): 2966–2977.
Published: 15 August 2012
... of BCDO2 in human cell lines. We found that carotenoids caused oxidative stress in mitochondria that eventually led to cytochrome c release, proteolytic activation of caspase 3 and PARP1, and execution of the apoptotic pathway. Moreover, BCDO2 prevented this induction of the apoptotic pathway...
Includes: Supplementary data