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Keywords: Mitf
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Journal Articles
Journal: Development
Development (2022) 149 (2): dev194407.
Published: 24 January 2022
... the melanocyte lineage. Indeed, β-catenin regulates transcription of Mitf-M, the master regulator of this lineage. The first wave of melanocytes to colonize the skin is directly derived from neural crest cells, whereas the second wave of melanocytes is derived from Schwann cell precursors (SCPs). We investigated...
Includes: Supplementary data
Journal Articles
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Neural development
Journal: Development
Development (2020) 147 (21): dev187047.
Published: 13 July 2020
... through which vasculature enters the eye and ganglion cell axons exit. Although many factors have been identified that function during CF closure, the molecular and cellular mechanisms mediating this process remain poorly understood. Failure of CF closure results in colobomas. Recently, MITF was shown...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (4): 620–632.
Published: 15 February 2015
.... , Lübke , M. , et al. ( 2012 ). Sox2 and Mitf cross-regulatory interactions consolidate progenitor and melanocyte lineages in the cranial neural crest . Development   139 , 397 - 410 . 10.1242/dev.065581 Alonso-Curbelo , D. , Riveiro-Falkenbach , E. , Pérez-Guijarro , E...
Journal Articles
Journal: Development
Development (2013) 140 (24): 4959–4969.
Published: 15 December 2013
... or inhibition of Wnt, but not Wnt/β-catenin, signalling prevents pigmentation and downregulates the RPE regulatory gene Mitf . Activation of BMP or Wnt signalling can replace the surface ectoderm to rescue MITF expression and optic cup formation. We provide evidence that BMPs and Wnts cooperate via a GSK3β...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (13): 2711–2723.
Published: 1 July 2013
..., ocular coloboma. Defective FGF signaling does not abrogate Shh or BMP signaling, nor does it affect axial patterning of the optic vesicle. Instead, FGF signaling regulates Mitf and Pax2 in coordinating the closure of the optic fissure and optic disc specification, which is necessary for the outgrowth...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (11): 2269–2279.
Published: 1 June 2013
... the melanogenic markers Mitf and MC/1 and the guidance receptor Ednrb2, generating instead glial cells that express P0 and Fabp. In this context, Foxd3 lies downstream of Snail2 and Sox9 , constituting a minimal network upstream of Mitf and Ednrb2 to link melanogenic specification with migration. Consistent...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (18): 3943–3954.
Published: 15 September 2011
...: HEK293 cells and FO-1 cells were cultured in Dulbecco's minimal essential medium supplemented with 10% of fetal calf serum. Cells were transiently transfected as previously described ( Delmas et al., 2007 ). Adenoviruses containing gfp alone or gfp and Mitf have been described elsewhere ( Gaggioli et al...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (11): 1849–1858.
Published: 1 June 2009
... is expressed exclusively in the neural/glial precursors and MITF is expressed only in melanoblasts. Moreover, FOXD3 represses melanogenesis. Here we show that avian MITF expression begins very early during melanoblast migration and that loss of MITF in melanoblasts causes them to transdifferentiate to a glial...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (1): 177–187.
Published: 1 January 2005
... (RPE) progenitors expressing the transcription factor Mitf. Chx10 mutations lead to microphthalmia and impaired neuroretinal proliferation. Mitf mutants have a dorsal RPE-to-neuroretinal phenotypic transformation, indicating that Mitf is a determinant of RPE identity. We report here that Mitf...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (20): 5139–5152.
Published: 15 October 2004
.... This program involved the expansion of expression of genes normally found only in the periphery into central regions of the eye. These genes included a transcription factor controlling pigmentation, Mitf , and the related factor Tfec ( Tcfec – Mouse Genome Informatics), which can activate a melanogenic gene...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (14): 3239–3247.
Published: 15 July 2004
... were seen, although β-gal-positive cells survived( Fig. 1B ). Theseβ-gal-positive cells lacked characteristic melanoblast markers, including MITF (see below), and probably represent cells of other lineages. The results indicate that in vitro, Ednrb is required for the generation of melanocytes...
Journal Articles
Journal: Development
Development (2003) 130 (26): 6545–6553.
Published: 29 December 2003
... specific isoform of the microphtalmia-related transcription factor (Mitf). Mitf is a basic helix-loop-helix-leucine zipper transcription factor whose M isoform is restricted to neural crest derived melanocytes and is essential for the development of these cells in vertebrates from mammals to fish. What...
Journal Articles
Journal: Development
Development (2003) 130 (13): 2903–2915.
Published: 1 July 2003
...-epithelial and optic-stalk progenitor domains, suggesting redundant functions during retinal determination. Pax2; Pax6 compound mutants display a dose-dependent reduction in the expression of the melanocyte determinant Mitf, accompanied by transdifferentiation of retinal pigmented epithelium (RPE...
Journal Articles
Journal: Development
Development (2003) 130 (12): 2809–2818.
Published: 15 June 2003
... of the transcription factor mitfa , which itself is required for melanophore development. We demonstrate that the zebrafish mitfa promoter has sox10 binding sites necessary for activity in vitro, consistent with studies using mammalian cell cultures that have shown that Sox10 directly regulates Mitf expression...