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Keywords: Microtubules
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Journal Articles
Journal: Development
Development (2022) 149 (2): dev199997.
Published: 26 January 2022
... of nuclei remain untested. Here, using quantification of nuclei position and division orientation together with embryo explants, we show that short-ranged repulsive interactions between microtubule asters ensure the regular distribution and maintenance of nuclear positions in the embryo. Such ordered...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (24): dev199922.
Published: 15 December 2021
...Jessica E. M Dunleavy; Anne E. O'Connor; Hidenobu Okuda; D. Jo Merriner; Moira K. O'Bryan ABSTRACT Katanin microtubule-severing enzymes are crucial executers of microtubule regulation. Here, we have created an allelic loss-of-function series of the katanin regulatory B-subunit KATNB1 in mice. We...
Includes: Supplementary data
Journal Articles
Journal: Development
Series: REVIEW COMMONS TRANSFER
Development (2021) 148 (4): dev194993.
Published: 19 February 2021
... mechanisms of Vash1 on endothelial microtubules during formation of the trunk vasculature. We show that microtubules within venous-derived secondary sprouts are strongly and selectively detyrosinated in comparison with other endothelial cells, and that this difference is lost upon vash1 knockdown. Vash1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (3): dev195073.
Published: 5 February 2021
...Toshiya Kimura; Hiroko Saito; Miwa Kawasaki; Masatoshi Takeichi ABSTRACT Microtubules (MTs) regulate numerous cellular processes, but their roles in brain morphogenesis are not well known. Here, we show that CAMSAP3, a non-centrosomal microtubule regulator, is important for shaping the lateral...
Includes: Supplementary data
Journal Articles
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Plant development
Journal: Development
Development (2020) 147 (16): dev177964.
Published: 19 August 2020
... microtubule organization, cell wall composition and cell adhesion, which presumably impacts on the transmission of tensional forces in plants ( Amanda et al., 2016 ). Although most mechanosensitive channels that are calcium permissible exhibit mild phenotypes when mutated, loss of dek1 is embryonic lethal...
Journal Articles
Journal: Development
Development (2020) 147 (21): dev189290.
Published: 22 June 2020
... Ciliogenesis Autism Down Syndrome Microtubules Spindle DYRK1A [dual specificity tyrosine-(Y)-phosphorylation-regulated kinase 1 A] encodes a highly conserved serine-threonine protein kinase expressed during human embryonic brain development ( van Bon et al., 2016 ). Large-scale human genetics...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (12): dev189886.
Published: 17 June 2020
.... Using the touch receptor neurons (TRNs) of Caenorhabditis elegans , we find that mec-15(-) mutants display defects in microtubule formation, neurite growth, synaptic development and neuronal functions, and that these defects can be rescued by the loss of Hsp70/Hsp90 chaperones and co-chaperones. MEC-15...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2019) 146 (10): dev179036.
Published: 24 May 2019
... , A. , Abad , U. , Ali , O. , Andres Robin , A. , Vachez , L. , Larrieu , A. , Mellerowicz , E. J. , Taconnat , L. , Battu , V. , Stanislas , T. , et al. ( 2018 ). Transcriptional induction of cell wall remodelling genes is coupled to microtubule-driven growth isotropy...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (22): dev167031.
Published: 19 November 2018
... of basal anisotropic cell shape that is microtubule dependent and likely to involve JNK signaling. We propose a model in which a single morphogen can differentially regulate apical versus basal cell shape during tissue morphogenesis. α-Tubulin and β-tubulin are the monomeric building blocks...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2018) 145 (11): dev162255.
Published: 4 June 2018
... contribution of wall isotropy in organ emergence, through the disorganization of cortical microtubules. We show here that this disorganization is coupled with the transcriptional control of genes involved in wall remodelling. Some of these genes are induced when microtubules are disorganized and cells shift...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (10): dev156596.
Published: 17 May 2018
... through their association with the tips of growing interphase astral microtubules. Germ plasm RNPs are also associated with short cortical F-actin. We show that, in embryos mutant for the cytoskeletal regulator mid1ip1l , germ plasm RNPs fail to become recruited to the furrow, accumulating instead...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (10): dev156604.
Published: 17 May 2018
...Celeste Eno; Timothy Gomez; Diane C. Slusarski; Francisco Pelegri ABSTRACT Zebrafish germ plasm ribonucleoparticles (RNPs) become recruited to furrows of early zebrafish embryos through their association with astral microtubules ends. During the initiation of cytokinesis, microtubules are remodeled...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (5): dev158782.
Published: 8 March 2018
...You Kure Wu; Hiroki Umeshima; Junko Kurisu; Mineko Kengaku ABSTRACT Nuclear migration of newly born neurons is essential for cortex formation in the brain. The nucleus is translocated by actin and microtubules, yet the actual force generated by the interplay of these cytoskeletons remains elusive...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (24): 4573–4587.
Published: 15 December 2017
... regulation. The molecular mechanisms that cope with the disruptive effects of temperature variation are still poorly understood. Interestingly, one of five different β-tubulin paralogs, βTub97EF , was among the genes upregulated at low temperature in cultured Drosophila cells. As microtubules are known...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2016) 143 (18): 3272–3282.
Published: 15 September 2016
... revealed that such helical growth may be associated with helical arrays of cortical microtubules and of overlying cellulose microfibrils. An alternative mechanism of coiling that is based on differential contraction within a bilayer has also recently been identified and underlies at least some...
Journal Articles
Journal: Development
Development (2015) 142 (3): 555–566.
Published: 1 February 2015
... to filamentous actin as well as microtubules. This could implicate these molecules in selective trafficking of membrane proteins upstream of cytoskeletal reorganization, and identifies new roles for cilia-related proteins in cochlear PCP. Analysis of cochleae from P0 Bbs8 −/− mice revealed stereociliary...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (2): 363–374.
Published: 15 January 2015
... but must be actively reorganised to allow morphogenesis. Vesicle trafficking and the microtubule (MT) cytoskeleton contribute to regulating AJs but their interrelationship remains elusive. We carried out a detailed analysis of the role of MTs in cell remodelling during formation of the tracheal system...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (17): 3399–3409.
Published: 1 September 2014
... in the Go-induced neuronal cytoskeleton program is observed, from microtubule-dependent neurite outgrowth to actin-dependent lamellopodial induction. These findings describe a novel mechanism regulating the microtubule cytoskeleton in the nervous system. Our work in Drosophila and mammalian cells suggests...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (14): 2866–2874.
Published: 15 July 2014
...Jessica Olofsson; Katherine A. Sharp; Maja Matis; Bomsoo Cho; Jeffrey D. Axelrod Microtubules (MTs) are substrates upon which plus- and minus-end directed motors control the directional movement of cargos that are essential for generating cell polarity. Although centrosomal MTs are organized...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (10): 2119–2130.
Published: 15 May 2014
... the single Drosophila homologue of microtubule-associated Ser/Thr (MAST) kinases. dop interacts genetically with components of the dynein/dynactin complex and promotes dynein-dependent transport in the embryo. Loss of dop function reduces phosphorylation of Dynein intermediate chain, suggesting that dop...
Includes: Supplementary data