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Keywords: Microtubule
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Journal Articles
Journal: Development
Development dev.200415.
Published: 19 May 2022
... the importance of the cytoskeleton, including actin filaments and microtubules, on rice development and environmental responses. Yet, reliable in vivo cytoskeleton markers are lacking in rice, which critically limits our knowledge of cytoskeletal functions in living cells. Therefore, we generated bright...
Journal Articles
Journal: Development
Development (2021) 148 (16): dev187609.
Published: 13 August 2021
... in nociceptive sensory neurons in Drosophila larvae. Time course analyses reveal that Form3 is cell-autonomously required to promote dendritic arbor complexity. We show that form3 is required for the maintenance of a population of stable dendritic microtubules (MTs), and mutants exhibit defects...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (8): dev171579.
Published: 17 April 2019
...) and asymmetric transport in oocytes. The control of spindle length by Ensconsin is Kinesin-1 independent but centrosome separation and oocyte transport require targeting of Kinesin-1 to microtubules by Ensconsin. However, the molecular mechanism used for this targeting remains unclear. Ensconsin contains...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (3): dev171280.
Published: 4 February 2019
... 1 2019 © 2019. Published by The Company of Biologists Ltd 2019 http://www.biologists.com/user-licence-1-1/ Summary: The Rab23-Kif17 cargo complex associates with αTAT and Sirt2 to stabilize spindle microtubules, and transports the constituents of RhoA pathway to facilitate actin...
Journal Articles
Journal: Development
Development (2019) 146 (1): dev169664.
Published: 2 January 2019
... nutrients to the embryo. External yolk syncytial nuclei (e-YSN) undergo microtubule-dependent movements that distribute the nuclei over the large yolk mass. How e-YSN migration proceeds, and the role of the yolk microtubules, is not understood, but it is proposed that e-YSN are pulled vegetally...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (9): dev156950.
Published: 11 May 2018
... in their proximal regions, but how this spatial information is encoded is not clear. Dendrite severing is preceded by local breakdown of dendritic microtubules through PAR-1-mediated inhibition of Tau. Here, we investigated spatial aspects of microtubule breakdown during dendrite pruning. Live imaging...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (6): dev158519.
Published: 16 March 2018
..., such as neuromuscular junctions. Despite the identification of numerous proteins that regulate synaptic actin and microtubule dynamics, the mechanisms of cytoskeletal control during terminal arbor formation have remained largely elusive. Here, we show that DAAM, a member of the formin family of cytoskeleton organizing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (17): 3012–3021.
Published: 1 September 2017
...Andrew Muroyama; Terry Lechler Over the past several decades, numerous studies have greatly expanded our knowledge about how microtubule organization and dynamics are controlled in cultured cells in vitro . However, our understanding of microtubule dynamics and functions in vivo , in differentiated...
Journal Articles
Journal: Development
Development (2016) 143 (9): 1491–1501.
Published: 1 May 2016
... of core components of subdistal appendages (SDAs) and of recycling endosomes, which may be associated with premature extension of axonemal microtubules. Our data implicate CP110 in SDA assembly and ciliary vesicle docking, two requisite early steps in cilia formation. We suggest that CP110 has unique...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (15): 2704–2718.
Published: 1 August 2015
... altered dorsal organizer and mesendodermal gene expression, due to impaired dorsal determinant transport and Nodal signaling. Mechanistically, MZ dchs1b phenotypes can be explained in part by defective actin or microtubule networks, which appear bundled in mutants. Accordingly, disruption of actin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (24): 4716–4728.
Published: 15 December 2014
... and through a Pak-independent non-canonical pathway to promote outgrowth. Whether this non-canonical pathway converges to promote Cofilin-dependent F-actin reorganization in axonal growth remains elusive. We demonstrate that Sickie, a homolog of the human microtubule-associated protein neuron navigator 2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (8): 1785–1795.
Published: 15 April 2013
... by a conserved core Wnt/PCP pathway. However, the hair cell-intrinsic polarity machinery is poorly understood. Recent findings implicate hair cell microtubules in planar polarization of hair cells. To elucidate the microtubule-mediated polarity pathway, we analyzed Lis1 function in the auditory sensory...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (21): 4661–4671.
Published: 1 November 2011
...Dikla Dubin-Bar; Amir Bitan; Anna Bakhrat; Simha Amsalem; Uri Abdu Asymmetrical localization of mRNA transcripts during Drosophila oogenesis determines the anteroposterior and dorsoventral axes of the Drosophila embryo. Correct localization of these mRNAs requires both microtubule (MT) and actin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (10): 2133–2142.
Published: 15 May 2011
... © 2011. 2011 Seh1 (Nup44A) Mio NPC Nup107-160 Nucleoporin Oogenesis Meiosis Germline Drosophila Mtor (Tpr) Microtubule The pathways that control progression through the early meiotic cycle remain poorly understood in metazoans. Drosophila melanogaster provides...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (8): 1631–1641.
Published: 15 April 2011
... a mesenchymal-epithelial transition and form two apical domains at opposite ends. Extracellular lumens then form at the apical surfaces. We show that cortical actin and Ciona ezrin/radixin/moesin (ERM) are essential for lumen formation and that a polarized network of microtubules, which contributes to lumen...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (3): 543–552.
Published: 1 February 2011
... between the microtubule cytoskeleton and Wnt/PCP signaling during zebrafish gastrulation. First, we assessed the location of the centrosome/microtubule organizing center (MTOC) relative to the cell nucleus and the body axes, as a marker of cell polarity. The intracellular position of MTOCs was polarized...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (14): 2329–2339.
Published: 15 July 2010
..., including microtubules, are regulated in this process in vivo is largely unknown. Here, we show that neural tube closure in Xenopus depends on orthologs of two proteins: MID1, which is responsible for Opitz G/BBB syndrome in humans, and its paralog MID2. Depletion of the Xenopus MIDs (xMIDs) by morpholino...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (9): 1411–1421.
Published: 1 May 2009
...Colleen M. Guerin; Sunita G. Kramer The microtubule (MT) cytoskeleton is reorganized during myogenesis as individual myoblasts fuse into multinucleated myotubes. Although this reorganization has long been observed in cell culture, these findings have not been validated during development...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (19): 3239–3246.
Published: 1 October 2008
... remain to be understood. Here, we report two crucial roles of Incenp, an essential subunit of the chromosomal passenger complex (the Aurora B complex), in centrosome-independent spindle formation in Drosophila female meiosis. First, the initial assembly of spindle microtubules is drastically delayed...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (3): 463–471.
Published: 1 February 2008
...Ai-Guo Tian; Wu-Min Deng Specification of the anteroposterior (AP) axis in Drosophila oocytes requires proper organization of the microtubule and actin cytoskeleton. The establishment and regulation of cytoskeletal polarity remain poorly understood, however. Here, we show important roles...
Includes: Supplementary data