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Keywords: Microphthalmia
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Journal Articles
Journal: Development
Development (2015) 142 (17): 3009–3020.
Published: 1 September 2015
... primordium, Meis1 coordinates, in a dose-dependent manner, retinal proliferation and differentiation by regulating genes responsible for human microphthalmia and components of the Notch signaling pathway. In addition, Meis1 is required for eye patterning by controlling a set of eye territory-specific...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (13): 2340–2350.
Published: 1 July 2012
... vasculature is unknown. In this study we explored the function of Vhl and Hif1a in the developing RPE using a tissue-specific conditional-knockout approach. We found that deletion of Vhl in the RPE results in RPE apoptosis, aniridia and microphthalmia. Increased levels of Hif1a, Hif2a, Epo and Vegf...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (15): 2601–2611.
Published: 1 August 2009
... biosynthetic pathways: pigmentation defects and microphthalmia result from deficiencies in a GTP synthesis pathway and an ATP synthesis pathway,respectively. In the absence of ATP pathway activity, S phase of proliferative retinoblasts is prolonged and cell cycle exit is compromised, which results...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (21): 3567–3576.
Published: 1 November 2008
...Chunqiao Liu; Jeremy Nathans Microphthalmia, coloboma and persistent fetal vasculature within the vitreous cavity are among the most common human congenital ocular anomalies,and each has been associated with a variety of genetic disorders. Here we show that, in the mouse, loss of frizzled 5 (Fz5...
Journal Articles
Journal: Development
Development (2003) 130 (3): 539–552.
Published: 1 February 2003
... Kip1 . We find that p27 Kip1 is abnormally present in progenitors of Chx10 -null retinas, and that its ectopic localization is responsible for a significant amount of the proliferation defect in this microphthalmia model system. mRNA and protein expression patterns in these mice and in cyclin D1-null...
Journal Articles
Journal: Development
Development (2002) 129 (1): 167–174.
Published: 1 January 2002
... (Cx46) and α1 (Cx43), and which are encoded by three different genes. In a previous study, we reported that, with a disruption of Gja3 (α3 connexin), mice developed nuclear cataracts with a normal sized lens. We show that Gja8tm1 (α8–/–) mice develop microphthalmia with small lenses and nuclear...