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Keywords: Mesoderm induction
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Journal Articles
Journal: Development
Development (2017) 144 (6): 1008–1017.
Published: 15 March 2017
... microtissues in vitro that integrate both cell types in complex 3D structures. We established conditions for simultaneous differentiation of cardiomyocytes and endothelial cells from human pluripotent stem cells following initial cardiac mesoderm induction. The endothelial cells expressed cardiac markers...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (24): 4903–4913.
Published: 15 December 2013
... no competing financial interests. 26 4 2013 18 9 2013 © 2013. Published by The Company of Biologists Ltd 2013 Transcriptional derepression Embryonic axis formation Mesoderm induction Down syndrome Polycomb group proteins Xenopus During amphibian early...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (5): 1024–1033.
Published: 1 March 2013
...Stephen A. Green; Rachael P. Norris; Mark Terasaki; Christopher J. Lowe FGFs act in vertebrate mesoderm induction and also play key roles in early mesoderm formation in ascidians and amphioxus. However, in sea urchins initial characterizations of FGF function do not support a role in early mesoderm...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (7): 1127–1135.
Published: 1 April 2010
... interests statement The authors declare no competing financial interests. 1 2 2010 © 2010. 2010 Zebrafish no tail Mesoderm induction Nodal signalling Transcriptional regulation Notochord During early zebrafish development a nodal morphogen gradient patterns the embryo...
Journal Articles
Journal: Development
Development (2007) 134 (16): 2895–2902.
Published: 15 August 2007
... of undifferentiated ES cells. Instead,such manipulations restrict the ability of ES cells to commit to differentiation. ES cells lacking Fgf4 or treated with FGF receptor inhibitors resist neural and mesodermal induction, and are refractory to BMP-induced non-neural differentiation. Lineage commitment potential...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (3): 591–602.
Published: 1 February 2005
... an important role in embryonic patterning by regulating the production of a subset of active mature TGFβ proteins in specific sites. * Author for correspondence (e-mail: heabq9@chmcc.org ) 29 11 2004 ©2005. 2005 PACE4 TGFβ Mesoderm induction Vg1 In Xenopus , the initial...
Journal Articles
Journal: Development
Development (2004) 131 (22): 5613–5626.
Published: 15 November 2004
...Maki Daniels; Kazuya Shimizu; Aaron M. Zorn; Shin-ichi Ohnuma Mesoderm induction and patterning are primarily regulated by the concentration of locally expressed morphogens such as members of the TGFβsuperfamily. Smad2 functions as a transcription factor to regulate expression of mesodermal genes...
Journal Articles
Journal: Development
Development (2004) 131 (20): 4977–4986.
Published: 15 October 2004
.... Here, we show that activin, the function of which in mesoderm induction has hitherto been unclear, also plays a role in mesoderm formation. Inhibition of activin function using antisense morpholino oligonucleotides interferes with mesoderm formation in a concentration-dependent manner and also changes...
Journal Articles
Journal: Development
Development (2004) 131 (8): 1717–1728.
Published: 15 April 2004
...-mail: ejrobert@fas.harvard.edu ) 7 1 2004 © 2004. 2004 Mesoderm induction Smad2/3 Axis patterning Nodal Mouse Members of the Transforming Growth Factor β (TGFβ) superfamily of secreted growth factors regulate numerous embryonic processes, from axis formation and mesoderm...
Journal Articles
Journal: Development
Development (2002) 129 (20): 4867–4876.
Published: 15 October 2002
... of this work. We are also grateful to Caroline Hill for the XlFast-1 construct and for much helpful advice. References Agius, E., Oelgeschlager, M., Wessely, O., Kemp, C. and de Robertis, E. M. ( 2000 ). Endodermal Nodal-related signals and mesoderm induction in Xenopus . Development 127 , 1173...
Journal Articles
Journal: Development
Development (2002) 129 (13): 3089–3103.
Published: 1 July 2002
...Peter M. Eimon; Richard M. Harland Derrière is a recently discovered member of the TGFβ superfamily that can induce mesoderm in explant assays and is expressed at the right time and location to mediate mesoderm induction in response to VegT during Xenopus embryogenesis. We show that the ability...
Journal Articles
Journal: Development
Development (2001) 128 (15): 2939–2952.
Published: 1 August 2001
... is a determinant of patterning in the early Xenopus embryo. *Author for correspondence (e-mail: mwhitman@hms.harvard.edu ) 16 5 2001 © 2001. 2001 Smad Phosphorylation TGFβ Nodal Mesoderm induction Signal transduction Xenopus laevis In the developing Xenopus embryo...
Journal Articles
Journal: Development
Development (1992) 116 (Supplement): 143–149.
Published: 1 April 1992
... sequence is provided. This suggests that int-2 and eFGF, which possess signal sequences, are better candidates for inducing factors in vivo than is bFGF. Copyright © 1992 by Company of Biologists 1992 Xenopus gastrulation mesoderm induction dorsoventral specification anteroposterior...
Journal Articles
Journal: Development
Development (1992) 116 (Supplement): 151–156.
Published: 1 April 1992
... embryo amphibian embryo pattern formation mesoderm induction embryonic axis Hensen's node stem cells Development 1992 Supplement, 151-156(1992) Printed in Great Britain © The Company of Biologists Limited 1992 151 Relationships between mesoderm induction and the embryonic axes in chick and frog...
Journal Articles
Journal: Development
Development (1992) 116 (Supplement): 127–136.
Published: 1 April 1992
... of gastrulation? What is the molecular basis of gastrulation? Copyright © 1992 by Company of Biologists 1992 Xenopus gastrulation mesoderm induction activin BMP-4 FGF Wnt integrins Mesoderm induction and origins of the embryonic axis Development 1992 Supplement, 127-136(1992) Printed in Great...
Journal Articles
Journal: Development
Development (1991) 113 (Supplement_1): 95–104.
Published: 1 January 1991
..., Cambridge CB2 1QR, UK Copyright © 1991 by Company of Biologists 1991 helix-loop-helix proteins mesoderm induction myogenesis neural crest neural induction Xenopus laevis Development Supplement 1, 1991, 95-104 Printed in Great Britain © The Company of Biologists Limited 1991 95 Gene...
Journal Articles
Journal: Development
Development (1989) 107 (Supplement): 149–159.
Published: 1 April 1989
..., and an analysis of the timing of the gastru- lation movements induced by the factors. Key words: mesoderm induction, mesoderm-inducing factors, bFGF, XTC-MIF, thresholds, gastrulation, amphibian embryo, Xenopus laevis, developmental timers. Introduction The mesoderm of Xenopus laevis, and of other amphib- ian...
Journal Articles
Journal: Development
Development (1989) 107 (Supplement): 141–148.
Published: 1 April 1989
... in the embryo. Lithium salts have a dorsalizing effect on whole embryos or on explants from the ventral marginal zone, and also show potent synergism when applied together with HBGFs. Key words: Xenopus laevis, mesoderm induction, mesoderm-inducing factors, fibroblast growth factor, fibroblast growth factor...
Journal Articles
Journal: Development
Development (1989) 107 (Supplement): 37–51.
Published: 1 April 1989
..., mesoderm induction, microtubules, gastrulation, polarity, FGF, TGF/J, anteroposterior pattern, dorsoventral pattern, lithium, D2O, organizer. I. Organization and reorganization of the egg: The egg's initial symmetry arises in oogenesis The unfertilized Xenopus egg displays polarized cylin- drical symmetry...
Journal Articles
Journal: Development
Development (1989) 105 (4): 665–677.
Published: 1 April 1989
...J. C. SMITH Development 105, 665-677 (1989) Printed in Great Britain © T h e Company of Biologists Limited 1989 Review Article 665 Mesoderm induction and mesoderm-inducing factors in early amphibian development J. C. SMITH Laboratory of Embryogenesis, National Institute for Medical Research...