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Keywords: Mesoderm induction
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Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2013) 140 (5): 1024–1033.
Published: 1 March 2013
...Stephen A. Green; Rachael P. Norris; Mark Terasaki; Christopher J. Lowe FGFs act in vertebrate mesoderm induction and also play key roles in early mesoderm formation in ascidians and amphioxus. However, in sea urchins initial characterizations of FGF function do not support a role in early mesoderm...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (7): 1127–1135.
Published: 1 April 2010
... interests statement The authors declare no competing financial interests. 1 2 2010 © 2010. 2010 Zebrafish no tail Mesoderm induction Nodal signalling Transcriptional regulation Notochord During early zebrafish development a nodal morphogen gradient patterns the embryo...
Journal Articles
Journal: Development
Development (2007) 134 (16): 2895–2902.
Published: 15 August 2007
... of undifferentiated ES cells. Instead,such manipulations restrict the ability of ES cells to commit to differentiation. ES cells lacking Fgf4 or treated with FGF receptor inhibitors resist neural and mesodermal induction, and are refractory to BMP-induced non-neural differentiation. Lineage commitment potential...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2004) 131 (22): 5613–5626.
Published: 15 November 2004
...Maki Daniels; Kazuya Shimizu; Aaron M. Zorn; Shin-ichi Ohnuma Mesoderm induction and patterning are primarily regulated by the concentration of locally expressed morphogens such as members of the TGFβsuperfamily. Smad2 functions as a transcription factor to regulate expression of mesodermal genes...
Journal Articles
Journal: Development
Development (2004) 131 (20): 4977–4986.
Published: 15 October 2004
.... Here, we show that activin, the function of which in mesoderm induction has hitherto been unclear, also plays a role in mesoderm formation. Inhibition of activin function using antisense morpholino oligonucleotides interferes with mesoderm formation in a concentration-dependent manner and also changes...
Journal Articles
Journal: Development
Development (2004) 131 (8): 1717–1728.
Published: 15 April 2004
... ) 7 1 2004 © 2004. 2004 Mesoderm induction Smad2/3 Axis patterning Nodal Mouse Members of the Transforming Growth Factor β (TGFβ) superfamily of secreted growth factors regulate numerous embryonic processes, from axis formation and mesoderm patterning to allocation...
Journal Articles
Journal: Development
Development (2002) 129 (20): 4867–4876.
Published: 15 October 2002
... members. The work confirms that derrière plays an important role in mesoderm formation and it illustrates the complex regulation to which inducing factors are subject. †Author for correspondence (e-mail: jim@welc.cam.ac.uk ) 2 7 2002 © 2002. 2002 Xenopus Mesoderm induction...
Journal Articles
Journal Articles
Journal: Development
Development (2001) 128 (15): 2939–2952.
Published: 1 August 2001
... is a determinant of patterning in the early Xenopus embryo. *Author for correspondence (e-mail: mwhitman@hms.harvard.edu ) 16 5 2001 © 2001. 2001 Smad Phosphorylation TGFβ Nodal Mesoderm induction Signal transduction Xenopus laevis In the developing Xenopus embryo...
Journal Articles
Journal: Development
Development (2000) 127 (13): 2917–2931.
Published: 1 July 2000
.... * These authors contributed equally to this work ‡ Author for correspondence (e-mail: mwhitman@hms.harvard.edu ) 11 04 2000 13 06 2000 © 2000 by Company of Biologists 2000 Smad TGFβ Phosphorylation Mesoderm induction Signal transduction Xenopus laevis Mesoderm...
Journal Articles
Journal: Development
Development (2000) 127 (7): 1455–1465.
Published: 1 April 2000
... B-Vg1 -mediated, but not by eFGF -mediated, mesoderm induction in animals caps. However, wild-type XHNF1 β mRNA does not trigger Xbra expression in animal caps. We conclude that XHNF1 β function is essential, though not sufficient, for mesoderm induction in the Xenopus embryo. Vg1 and VegT...
Journal Articles
Journal: Development
Development (2000) 127 (6): 1173–1183.
Published: 15 March 2000
...Eric Agius; Michael Oelgeschläger; Oliver Wessely; Caroline Kemp; E. M. De Robertis ABSTRACT In Xenopus , mesoderm induction by endoderm at the blastula stage is well documented, but the molecular nature of the endogenous inductive signals remains unknown. The carboxy-terminal fragment of Cerberus...
Journal Articles
Journal: Development
Development (1999) 126 (24): 5621–5634.
Published: 15 December 1999
... regulator of mesoderm induction by ectopic TGFβ superfamily ligands and during endogenous patterning: ectopic expression of mutationally activated FAST-1, ectopic expression of dominant inhibitory FAST-1, and injection of a blocking antibody specific for FAST-1. Expression of constitutively...
Journal Articles
Journal: Development
Development (1999) 126 (21): 4903–4911.
Published: 1 November 1999
... for correspondence (e-mail: hw@dna.bio.warwick.ac.uk ) 20 08 1999 06 10 1999 © 1999 by Company of Biologists 1999 VegT Mesoderm induction Endoderm TGF-β, Xenopus The amphibian embryo develops into the three germ layers in a predictable fashion, the pigmented animal pole...
Journal Articles
Journal: Development
Development (1999) 126 (14): 3229–3240.
Published: 15 July 1999
... a dominant negative cleavage mutant Xnr2 (cmXnr2) to carry out loss-of-function experiments to explore the requirement for Xnr signaling in early amphibian embryogenesis, and the relationship between activin and Xnrs. cmXnr2 blocked mesoderm induction caused by Xnr , but not activin , RNA. In contrast...
Journal Articles
Journal: Development
Development (1998) 125 (10): 1931–1942.
Published: 15 May 1998
.... , Ishii , K. , Shibai , H. and Ueno , N. ( 1990 ). Mesoderm induction in early amphibian embryo by activin A (erythroid differentiation factor ). Roux’s Arch. Dev. Biol . 198 , 330 – 335 . 10.1007/BF00383771 Carnac , G. , Kodjabachian , L. , Gurdon , J.B...
Journal Articles