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Keywords: Mesoderm
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Journal Articles
Journal Articles
Journal: Development
Development (2024) 151 (3): dev202116.
Published: 12 February 2024
..., homeostasis and healing. Like the craniofacial bones, the sutures are formed from both mesoderm and neural crest. During cranial bone repair, neural crest cells have been proposed to be key players; however, neural crest contributions to adult sutures are not well defined, and the relative importance...
Journal Articles
Journal: Development
Development (2022) 149 (3): dev200033.
Published: 14 February 2022
... cord regeneration. Here, using RNA-seq analysis, we discovered that the inhibition of miR-200a results in an upregulation of the classical mesodermal marker brachyury in spinal cord cells after injury. However, these cells still express the neural stem cell marker sox2 . In vivo cell tracking allowed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (1): dev193789.
Published: 7 January 2021
...Simone Probst; Sagar; Jelena Tosic; Carsten Schwan; Dominic Grün; Sebastian J. Arnold ABSTRACT Anterior mesoderm (AM) and definitive endoderm (DE) progenitors represent the earliest embryonic cell types that are specified during germ layer formation at the primitive streak (PS) of the mouse embryo...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (10): dev189324.
Published: 27 May 2020
... role in Wnt signaling, Rspo2 acts as an FGF antagonist during mesoderm formation and patterning. Taken together, our experiments identify TSP as the domain responsible for the inhibitory effect of Rspo2 on FGF signaling. Fig. 4. The intramolecular interaction of protein domains in Rspo2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (1): dev181040.
Published: 8 January 2020
...Isao Kobayashi; Jingjing Kobayashi-Sun; Yuto Hirakawa; Madoka Ouchi; Koyuki Yasuda; Hiroyasu Kamei; Shigetomo Fukuhara; Masaaki Yamaguchi ABSTRACT In order to efficiently derive hematopoietic stem cells (HSCs) from pluripotent precursors, it is crucial to understand how mesodermal cells acquire...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (7): dev170498.
Published: 1 April 2019
...Tanya E. Foley; Bradley Hess; Joanne G. A. Savory; Randy Ringuette; David Lohnes ABSTRACT Murine cardiac and hematopoietic progenitors are derived from Mesp1 + mesoderm. Cdx function impacts both yolk sac hematopoiesis and cardiogenesis in zebrafish, suggesting that Cdx family members regulate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (23): dev164160.
Published: 3 December 2018
... and Utf1 are de-repressed whereas mesoderm development-related genes, including BMP4 signaling-related genes, are downregulated by Setdb1 knockdown during PGC-like cell (PGCLC) induction. In addition, binding of SETDB1 is observed at the flanking regions of Dppa2 , Otx2 and Utf1 in cell aggregates...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (18): dev147769.
Published: 17 September 2018
... to be an instructive signal in mesoderm formation during gastrulation. Here, we show in Xenopus that RARγ is indispensable for the expression of early mesoderm markers and is, therefore, an obligatory factor in mesodermal competence and/or maintenance. We identified several novel targets upregulated by RA receptor...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (17): dev166801.
Published: 17 August 2018
... the fate of major mesodermal subcompartments in mice we present evidence that <50% of interscapular brown adipocytes are derived from progenitors of the central dermomyotome. Furthermore, we demonstrate that depot-specific adipocyte lineages spatially diverge as early as gastrulation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (21): 4026–4036.
Published: 1 November 2017
...://www.biologists.com/user-licence-1-1/ Summary: PDGFRα-PI3K/AKT signaling plays an essential role in the developing calvarial tissues of mouse by regulating endochondral ossification in cartilage anlagen underlying coronal sutures derived from neural crest and mesoderm. Craniosynostosis Endochondral...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (16): 2951–2960.
Published: 15 August 2017
...Marc D. Servetnick; Bailey Steinworth; Leslie S. Babonis; David Simmons; Miguel Salinas-Saavedra; Mark Q. Martindale ABSTRACT The mesoderm is a key novelty in animal evolution, although we understand little of how the mesoderm arose. brachyury , the founding member of the T-box gene family...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (7): 1283–1295.
Published: 1 April 2017
...Mariana L. Stevens; Praneet Chaturvedi; Scott A. Rankin; Melissa Macdonald; Sajjeev Jagannathan; Masashi Yukawa; Artem Barski; Aaron M. Zorn Digestive system development is orchestrated by combinatorial signaling interactions between endoderm and mesoderm, but how these signals are interpreted...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (20): 3733–3741.
Published: 15 October 2016
...Melinda Snitow; MinMin Lu; Lan Cheng; Su Zhou; Edward E. Morrisey During development, the lung mesoderm generates a variety of cell lineages, including airway and vascular smooth muscle. Epigenetic changes in adult lung mesodermal lineages are thought to contribute towards diseases...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (8): 1340–1350.
Published: 15 April 2016
... of transcription initiation that involves mesoderm and organizer gene expression. Using TBP family single- and triple-knockdown experiments, α-amanitin treatment, transcriptome profiling and chromatin immunoprecipitation, we found that TFI gene expression cannot be explained by functional redundancy, is supported...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (21): 3649–3660.
Published: 1 November 2015
.... These are fully rescued in a RBPJ-deficient background. Epiblast-specific NOTCH activation induces acquisition of neurectoderm identity and disrupts the formation of specific mesodermal precursors including the derivatives of the anterior primitive streak, the mouse organiser. In addition, we show that forced...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (19): 3307–3320.
Published: 1 October 2015
...Maud Fleury; Alexia Eliades; Peter Carlsson; Georges Lacaud; Valerie Kouskoff The molecular mechanisms orchestrating early mesoderm specification are still poorly understood. In particular, how alternate cell fate decisions are regulated in nascent mesoderm remains mostly unknown. In the present...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (11): 1937–1947.
Published: 1 June 2015
...Minoru Takasato; Melissa H. Little ABSTRACT The mammalian kidney, the metanephros, is a mesodermal organ classically regarded as arising from the intermediate mesoderm (IM). Indeed, both the ureteric bud (UB), which gives rise to the ureter and the collecting ducts, and the metanephric mesenchyme...
Journal Articles
Journal: Development
Development (2015) 142 (8): 1418–1430.
Published: 15 April 2015
... understood. Here, we show that the chromatin remodeling factor Brg1 is required for enhancer activation in mesoderm induction. In an embryonic stem cell-based directed differentiation assay, the absence of Brg1 results in a failure of cardiomyocyte differentiation and broad deregulation of lineage-specific...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (22): 4231–4242.
Published: 15 November 2014
... reporter ES cell line to monitor neural development ( Ying et al., 2003 ), and a TBX6::EYFP line to follow the emergence of mesoderm (see Materials and Methods). We also included BMP (see also Fig. 1C ) in the repertoire of signals, as it plays a role in the early stages of embryonic patterning ( Arnold...
Includes: Supplementary data