... cord regeneration. Here, using RNA-seq analysis, we discovered that the inhibition of miR-200a results in an upregulation of the classical mesodermal marker brachyury in spinal cord cells after injury. However, these cells still express the neural stem cell marker sox2 . In vivo cell tracking allowed...

...Simone Probst; Sagar; Jelena Tosic; Carsten Schwan; Dominic Grün; Sebastian J. Arnold ABSTRACT Anterior mesoderm (AM) and definitive endoderm (DE) progenitors represent the earliest embryonic cell types that are specified during germ layer formation at the primitive streak (PS) of the mouse embryo...

... role in Wnt signaling, Rspo2 acts as an FGF antagonist during mesoderm formation and patterning. Taken together, our experiments identify TSP as the domain responsible for the inhibitory effect of Rspo2 on FGF signaling. Fig. 4. The intramolecular interaction of protein domains in Rspo2...

...Isao Kobayashi; Jingjing Kobayashi-Sun; Yuto Hirakawa; Madoka Ouchi; Koyuki Yasuda; Hiroyasu Kamei; Shigetomo Fukuhara; Masaaki Yamaguchi ABSTRACT In order to efficiently derive hematopoietic stem cells (HSCs) from pluripotent precursors, it is crucial to understand how mesodermal cells acquire...

...Tanya E. Foley; Bradley Hess; Joanne G. A. Savory; Randy Ringuette; David Lohnes ABSTRACT Murine cardiac and hematopoietic progenitors are derived from Mesp1 + mesoderm. Cdx function impacts both yolk sac hematopoiesis and cardiogenesis in zebrafish, suggesting that Cdx family members regulate...

... and Utf1 are de-repressed whereas mesoderm development-related genes, including BMP4 signaling-related genes, are downregulated by Setdb1 knockdown during PGC-like cell (PGCLC) induction. In addition, binding of SETDB1 is observed at the flanking regions of Dppa2 , Otx2 and Utf1 in cell aggregates...

... to be an instructive signal in mesoderm formation during gastrulation. Here, we show in Xenopus that RARγ is indispensable for the expression of early mesoderm markers and is, therefore, an obligatory factor in mesodermal competence and/or maintenance. We identified several novel targets upregulated by RA receptor...

... the fate of major mesodermal subcompartments in mice we present evidence that <50% of interscapular brown adipocytes are derived from progenitors of the central dermomyotome. Furthermore, we demonstrate that depot-specific adipocyte lineages spatially diverge as early as gastrulation...

...://www.biologists.com/user-licence-1-1/ Summary: PDGFRα-PI3K/AKT signaling plays an essential role in the developing calvarial tissues of mouse by regulating endochondral ossification in cartilage anlagen underlying coronal sutures derived from neural crest and mesoderm. Craniosynostosis Endochondral...

...Marc D. Servetnick; Bailey Steinworth; Leslie S. Babonis; David Simmons; Miguel Salinas-Saavedra; Mark Q. Martindale ABSTRACT The mesoderm is a key novelty in animal evolution, although we understand little of how the mesoderm arose. brachyury , the founding member of the T-box gene family...

...Mariana L. Stevens; Praneet Chaturvedi; Scott A. Rankin; Melissa Macdonald; Sajjeev Jagannathan; Masashi Yukawa; Artem Barski; Aaron M. Zorn Digestive system development is orchestrated by combinatorial signaling interactions between endoderm and mesoderm, but how these signals are interpreted...

...Melinda Snitow; MinMin Lu; Lan Cheng; Su Zhou; Edward E. Morrisey During development, the lung mesoderm generates a variety of cell lineages, including airway and vascular smooth muscle. Epigenetic changes in adult lung mesodermal lineages are thought to contribute towards diseases...

... of transcription initiation that involves mesoderm and organizer gene expression. Using TBP family single- and triple-knockdown experiments, α-amanitin treatment, transcriptome profiling and chromatin immunoprecipitation, we found that TFI gene expression cannot be explained by functional redundancy, is supported...

.... These are fully rescued in a RBPJ-deficient background. Epiblast-specific NOTCH activation induces acquisition of neurectoderm identity and disrupts the formation of specific mesodermal precursors including the derivatives of the anterior primitive streak, the mouse organiser. In addition, we show that forced...

...Maud Fleury; Alexia Eliades; Peter Carlsson; Georges Lacaud; Valerie Kouskoff The molecular mechanisms orchestrating early mesoderm specification are still poorly understood. In particular, how alternate cell fate decisions are regulated in nascent mesoderm remains mostly unknown. In the present...

...Minoru Takasato; Melissa H. Little ABSTRACT The mammalian kidney, the metanephros, is a mesodermal organ classically regarded as arising from the intermediate mesoderm (IM). Indeed, both the ureteric bud (UB), which gives rise to the ureter and the collecting ducts, and the metanephric mesenchyme...

... understood. Here, we show that the chromatin remodeling factor Brg1 is required for enhancer activation in mesoderm induction. In an embryonic stem cell-based directed differentiation assay, the absence of Brg1 results in a failure of cardiomyocyte differentiation and broad deregulation of lineage-specific...

... reporter ES cell line to monitor neural development ( Ying et al., 2003 ), and a TBX6::EYFP line to follow the emergence of mesoderm (see Materials and Methods). We also included BMP (see also Fig. 1C ) in the repertoire of signals, as it plays a role in the early stages of embryonic patterning ( Arnold...

... and a binding partner, WBP11, in early development of Xenopus embryos. Both genes are expressed in the nascent mesoderm and neurectoderm, and morpholino knockdown of either causes defects in differentiation and morphogenesis of the mesoderm and neural plate. At the molecular level, knockdown of PQBP1 in Xenopus...

... of echinoids), their embryonic development clearly differs from that of euechinoids, particularly in relation to the process of mesoderm formation ( Schroeder, 1981 ) ( Fig. 1 ). Two types of mesenchyme cells are common in both euechinoids and cidaroids – skeletogenic cells and nonskeletogenic cells...