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Keywords: Meiosis
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Journal Articles
Journal: Development
Development (2022) 149 (22): dev200713.
Published: 16 November 2022
... by completing an essential lengthy differentiation program before initiating meiosis. The molecular and cellular changes directing these developmental processes remain largely undefined. This wide gap in knowledge is due to two unresolved technical challenges: (1) lack of robust and reliable in vitro models...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (21): dev200900.
Published: 24 October 2022
... pathway in meiosis II in Xenopus oocytes is mediated by p90(Rsk) . Curr. Biol. 10 , 430 - 438 . 10.1016/S0960-9822(00)00425-5 Haccard , O. and Jessus , C. ( 2006 ). Redundant pathways for Cdc2 activation in Xenopus oocyte: either cyclin B or Mos synthesis . EMBO Rep. 7...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (19): dev200497.
Published: 12 October 2022
... development. RTCB regulated the splicing of transcripts related to DNA methylation and DNA damage repair. In addition, it regulated the resumption of oocyte meiosis by affecting CDK1 activation. Moreover, the loss of RTCB suppressed zygotic genome activation (ZGA) and decreased translation at the global level...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (18): dev199967.
Published: 16 September 2022
... observed during distinct stages of gamete development, which include specific activities with critical meiotic functions. SWI/SNF chromatin remodelers are recognized regulators of gene transcription and DNA repair, but their composition and functions in meiosis are poorly understood. We have generated...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2022) 149 (10): dev200229.
Published: 30 May 2022
...Rudra Prasanna Banerjee; Martin Srayko ABSTRACT In most sexually reproducing animals, sperm entry provides the signal to initiate the final stages of female meiosis. In Caenorhabditis elegans , this signal is required for completion of female anaphase I and entry into meiosis II (MII). memi - 1/2/3...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2022) 149 (7): dev200345.
Published: 19 April 2022
... of parthenogenetic hybrids are genetic copies of their mother; however, the cellular mechanism enabling the production of unreduced cells is largely unknown. Here, we show that oocytes go through meiosis in three widespread, or even strongly invasive, obligate parthenogenetic complexes of geckos, namely in diploid...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2022) 149 (5): dev200231.
Published: 11 March 2022
..., which is associated with microtubules for the maintenance of spindle poles in mitosis, is also involved in actin dynamics in murine oocyte meiosis, co-localizing with microtubules during mouse oocyte maturation. Depletion of KIFC1 caused the failure of polar body extrusion, and we found that meiotic...
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2022) 149 (1): dev199625.
Published: 4 January 2022
... meiotic cell cycle entry factor. Thus, Msl3 regulates GSC differentiation by modulating translation of a key factor that promotes transition to an oocyte fate. References Ables , E. T. ( 2015 ). Drosophila oocytes as a model for understanding meiosis: an educational primer to accompany...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (21): dev199560.
Published: 29 October 2021
...Mansour Aboelenain; Karen Schindler ABSTRACT Mammalian oocytes are transcriptionally quiescent, and meiosis and early embryonic divisions rely on translation of stored maternal mRNAs. Activation of these mRNAs is mediated by polyadenylation. Cytoplasmic polyadenylation binding element 1 (CPEB1...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (11): dev199414.
Published: 8 June 2021
... show that loss of EWSR1 in late meiotic prophase I does not affect proper meiosis completion, but does result in defective spermatid elongation and chromocenter formation in the developing germ cells. As a result, male mice lacking EWSR1 after pachynema are sterile. We found that, in Ewsr1 CKO round...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (10): dev194605.
Published: 17 May 2021
... of meiosis, especially in the adult, is not well understood. Here, we reveal that NP95 (also known as UHRF1) and DNMT1 – two essential proteins for maintenance DNA methylation – are co-expressed in spermatogonia and are necessary for meiosis in male germ cells. We find that Np95 - or Dnmt1 -deficient...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (5): dev194977.
Published: 9 March 2021
...Chun-Wei Feng; Guillaume Burnet; Cassy M. Spiller; Fiona Ka Man Cheung; Kallayanee Chawengsaksophak; Peter Koopman; Josephine Bowles ABSTRACT In mice, the entry of germ cells into meiosis crucially depends on the expression of stimulated by retinoic acid gene 8 ( Stra8 ). Stra8 is expressed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (3): dev197780.
Published: 10 February 2021
...Daniel J. Barbosa; Vanessa Teixeira; Joana Duro; Ana X. Carvalho; Reto Gassmann ABSTRACT The microtubule motor cytoplasmic dynein 1 (dynein) and its essential activator dynactin have conserved roles in spindle assembly and positioning during female meiosis and mitosis, but their contribution...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (2): dev196931.
Published: 18 January 2021
... regulatory protein 1 (ESRP1) and found that it induced female infertility in mice. Esrp1 deletion perturbed spindle organization, chromosome alignment and metaphase-to-anaphase transformation in oocytes. The first polar body extrusion was blocked during oocyte meiosis owing to abnormal activation of spindle...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2020) 147 (22): dev193862.
Published: 27 November 2020
... of male meiosis . Development   138 , 3319 - 3330 . 10.1242/dev.067645 Brenner   S. ( 1974 ). The genetics of Caenorhabditis elegans . Genetics 77, 71-94 . Chen , P. and Ellis , R. E. ( 2000 ). TRA-1A regulates transcription of fog-3, which controls germ cell fate in C...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2020) 147 (6): dev183764.
Published: 17 March 2020
...Yu Jiang; Hui-Ying Zhang; Zhen Lin; Ye-Zhang Zhu; Chao Yu; Qian-Qian Sha; Ming-Han Tong; Li Shen; Heng-Yu Fan ABSTRACT The most significant feature of meiosis is the recombination process during prophase I. CXXC finger protein 1 (CXXC1) binds to CpG islands and mediates the deposition of H3K4me3...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (2): dev182063.
Published: 15 January 2020
.... and Hawley , R. S. ( 2018 ). Female meiosis: synapsis, recombination, and segregation in Drosophila melanogaster . Genetics   208 , 875 - 908 . 10.1534/genetics.117.300081 Jang , J. K. , Sherizen , D. E. , Bhagat , R. , Manheim , E. A. and McKim , K. S. ( 2003...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2019) 146 (23): dev182519.
Published: 2 December 2019
...Jian Li; Ying-Chun Ouyang; Chun-Hui Zhang; Wei-Ping Qian; Qing-Yuan Sun ABSTRACT Chromosome segregation is driven by separase, activity of which is inhibited by binding to securin and cyclin B1/CDK1. In meiosis, premature separase activity will induce aneuploidy or abolish chromosome segregation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (20): dev178863.
Published: 21 October 2019
...://www.biologists.com/user-licence-1-1/ Summary: Using three different genetic backgrounds to manipulate spindle shape without eliminating dynein-dependent movement or dynein localization, we reveal that spindle shape ensures correct orientation at the oocyte cortex to prevent lethal polyploidy. Meiosis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (8): dev172734.
Published: 26 April 2019
...Enrico Maria Daldello; Xuan G. Luong; Cai-Rong Yang; Jonathan Kuhn; Marco Conti ABSTRACT Cyclins associate with cyclin-dependent serine/threonine kinase 1 (CDK1) to generate the M phase-promoting factor (MPF) activity essential for progression through mitosis and meiosis. Although cyclin B1 (CCNB1...
Includes: Supplementary data