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Keywords: Medulloblastoma
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Journal Articles
Journal: Development
Development (2021) 148 (2): dev193342.
Published: 20 January 2021
...: This Spotlight article looks at three of the most common paediatric brain tumours as examples of how understanding of developmental lineages and mechanisms has advanced understanding of these cancers. Diffuse intrinsic pontine glioma Ependymoma Medulloblastoma Paediatric tumours Brain...
Journal Articles
In collection:
Neural development
Journal: Development
Development (2020) 147 (21): dev188078.
Published: 15 June 2020
... to various disorders, including the cerebellar cancer medulloblastoma (MB). We recently identified RNF220, a ubiquitin E3 ligase promoting K63-linked polyubiquitylation and nuclear exportation of Gli transcription factors, as an Shh/Gli regulator involved in ventral neural patterning. Here, we report...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2019) 146 (20): dev177550.
Published: 10 October 2019
... medulloblastoma, the most common malignant pediatric brain tumor. Although sonic hedgehog (SHH) signaling is known to activate CGNP proliferation, the mechanisms downregulating proliferation are less defined. We investigated CGNP regulation by GSK-3, which downregulates proliferation in the forebrain, gut...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2016) 143 (21): 4038–4052.
Published: 1 November 2016
...Patrick Y. Lang; Gouri J. Nanjangud; Marina Sokolsky-Papkov; Christine Shaw; Duhyeong Hwang; Joel S. Parker; Alexander V. Kabanov; Timothy R. Gershon Microcephaly and medulloblastoma may both result from mutations that compromise genomic stability. We report that ATR, which is mutated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (22): 3921–3932.
Published: 15 November 2015
... and brain tumor formation. Here, we report that Aspm , a gene that is mutated in familial microcephaly, regulates postnatal neurogenesis in the cerebellum and supports the growth of medulloblastoma, the most common malignant pediatric brain tumor. Cerebellar granule neuron progenitors (CGNPs) express Aspm...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (21): 4031–4041.
Published: 1 November 2014
... interests The authors declare no competing financial interests. © 2014. Published by The Company of Biologists Ltd 2014 Granule cell Atoh1 Autistic spectrum disorder Medulloblastoma Ptf1a Purkinje cell The cerebellum (‘little brain’) resides at the anterior end of the hindbrain...
Journal Articles
Journal: Development
Development (2006) 133 (19): 3929–3937.
Published: 1 October 2006
...Jennifer Pogoriler; Kathleen Millen; Manuel Utset; Wei Du Medulloblastoma, the most common malignant brain tumor of childhood, is believed to derive from immature granule neuron precursors (GNPs) that normally proliferate in the external granule layer before exiting the cell cycle and migrating...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (10): 2425–2439.
Published: 15 May 2005
...Trudy G. Oliver; Tracy Ann Read; Jessica D. Kessler; Anriada Mehmeti; Jonathan F. Wells; Trang T. T. Huynh; Simon M. Lin; Robert J. Wechsler-Reya Medulloblastoma is the most common malignant brain tumor in children. It is thought to result from the transformation of granule cell precursors (GCPs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (1): 217–228.
Published: 1 January 2004
... in the cerebellar tumor medulloblastoma. Here, we describe a mechanism through which these disparate signaling pathways cooperate to promote proliferation of cerebellar granule neuron precursors. Shh signaling drives expression of mRNA encoding the Nmyc1 oncoprotein (previously N-myc),which is essential...
Journal Articles
Journal: Development
Development (2003) 130 (1): 15–28.
Published: 1 January 2003
...Anna Marie Kenney; Michael D. Cole; David H. Rowitch Hedgehog pathway activation is required for expansion of specific neuronal precursor populations during development and is etiologic in the human cerebellar tumor, medulloblastoma. We report that sonic hedgehog (Shh)signaling upregulates...