... Mechanobiology Sensory development Neural crest Placodes Stem cells Organoids Funding K.R.K., A.P.L. and J.K. are supported by grants from the National Institute on Deafness and Other Communication Disorders (R01 DC017461) and from the National Institute of Arthritis and Musculoskeletal and Skin...

... self-organize into trunk-like structures with neural tube and somites . Science 370 , eaba4937 . 10.1126/science.aba4937 Vianello , S. and Lutolf , M. P. ( 2019 ). Understanding the Mechanobiology of Early Mammalian Development through Bioengineered Models . Dev. Cell 48...

... tensile stress regulates valve development through a molecular switch potentiating BMP-pSMAD1/5-driven growth and pSer-19-MLC2-driven contractility. Mechanobiology Cardiac valve development BMP signaling MLC contractility Congenital heart defects (CHDs) are the most common birth defects...

... forces in development. Emphasising the importance of integrative approaches and theoretical simulations to obtain comprehensive mechanistic insights into complex morphogenetic processes, the meeting provided an ideal platform to discuss the concepts and methods of developmental mechanobiology in an era...

... Finite element model Growth law Mechanobiology Chick Highlighted Article: Using experiments and modeling, this study illustrates the importance of not only chemical morphogen gradients, but also mechanical stress distributions, in embryonic development of the cerebral hemispheres. ©...

... Mechanical Multiphysiological system Mechanobiology Human ‘organs on chips’ (organ chips) are microfluidic cell culture devices with separate parenchymal and vascular compartments lined by living human cells that mimic the multicellular architecture, tissue-tissue interfaces and relevant physical...

..., our molecular understanding of mechanobiology has advanced to explain how passive and active forces induce similar signaling cascades that drive self-renewal, migration, differentiation or a combination of these outcomes. Improvements in stem cell culture methods, materials and biophysical tools...

... tendon formation. Chick Limb Tendon Mechanobiology Scleraxis Tendon is a connective tissue that transmits the forces generated by muscle to bone and allows body motion. Type I collagen is the main structural and functional component of tendons. The signals regulating the production...