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Keywords: Mdm2
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Journal Articles
Journal: Development
Development (2015) 142 (7): 1357–1367.
Published: 1 April 2015
..., downstream targets of p53, was increased in the mutants; however, the p53 expression level was unchanged. It has been reported that MDM2 interacts with p53 to promote degradation. We found that the amount of MDM2-p53 complex was decreased in all mutants, and the most severely affected mutants had the largest...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (7): 1443–1451.
Published: 1 April 2007
... survival during embryogenesis. Here, we show that PI3K acts via mTOR (Frap1) to regulate p53 activity both in vitro and in vivo. mTOR inhibits p53 by promoting the translation of Mdm2, a negative regulator of p53. We also demonstrate that the PI3K effector Akt is required for Met-triggered Mdm2...
Includes: Supplementary data