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Keywords: Mathematical modelling
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Journal Articles
Journal: Development
Development (2024) 151 (2): dev202503.
Published: 19 January 2024
... of differentiation. Furthermore, by combining mathematical modelling and cell-based assays we show that the elimination of wild-type cells is not through competition for space or nutrients, but instead is mediated by short-range interactions that are dependent on the local cell neighbourhood. This highlights...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (24): dev201911.
Published: 21 December 2023
... Mathematical modelling Morphogenesis Noise Robustness Ministerio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 PID2021-122930NB-I00 CNS2022-135397 Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 CEX2020-001084-M The fine...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (8): dev183699.
Published: 12 April 2020
... Turing mechanism can reproduce a wide diversity of joint patterns observed in the tetrapod lineage, providing a unifying framework to interrogate joint patterning in the tetrapod limb. Limb patterning Mathematical modelling Turing patterns The acquisition of digits (fingers and toes...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2020) 147 (6): dev181669.
Published: 30 March 2020
... den Berg et al., 2016 ). Precise knowledge of the auxin dynamics within the root tip is essential to understand how these processes are controlled. Auxin transport Plasmodesmata Mathematical modelling Root biology Highlighted Article: A multicellular model of auxin transport...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (3): dev168955.
Published: 1 February 2019
... to interpret different forms of tissue gradients to establish planar polarity. Planar polarity Planar cell polarity (PCP) Patterning Gradient Mathematical modelling Asymmetry Many animal tissues show coordinated polarisation of cells along a planar axis. Such planar polarisation results...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (23): 4377–4385.
Published: 1 December 2017
... a previously unrecognized but highly reproducible pattern of branching. Branching morphogenesis Ureteric tree Mathematical modelling The increase in organ size associated with the evolution of complex body plans presents challenges for the organism in mediating the efficient exchange...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (1): 174–179.
Published: 1 January 2016
... in developing embryos. Here we use computer modelling and embryo experiments to explore the behaviour of tandem timers in developing systems. We present a mathematical model of timer kinetics and provide software tools that will allow experimentalists to select the most appropriate timer designs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (20): 3868–3878.
Published: 15 October 2014
... unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Approximate Bayesian computation Enhancer Gene regulation Gli Morphogen patterning Shh Mathematical modelling Transcriptional networks In many developing tissues, pattern...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (1): 63–72.
Published: 1 January 2014
... and differentiation of neuronal progenitors occurs in an anterior-posterior manner. We generated mathematical models to explain how Wnt and FGFs direct the spatial differentiation of neurons in the midbrain through Wnt regulation of FGF signalling. These models suggested that a negative-feedback loop controlled...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (10): 1913–1923.
Published: 15 May 2011
... acid Sonic hedgehog Mathematical modelling Mouse limb development Systems biology Next, we assessed the temporal relationship between the expression of Rarb, Cyp26b1 and Fgf8 , the first AER- Fgf expressed during limb bud development and investigated when the regulation of Cyp26b1...
Includes: Supplementary data