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Keywords: Mammary gland
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Journal Articles
Journal: Development
Development (2022) 149 (8): dev200162.
Published: 29 April 2022
...Jessica Hitchcock; Katherine Hughes; Sara Pensa; Bethan Lloyd-Lewis; Christine J. Watson ABSTRACT Post-lactational mammary gland regression encompasses extensive programmed cell death and removal of milk-producing epithelial cells, breakdown of extracellular matrix components and redifferentiation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (21): dev199940.
Published: 10 November 2021
...Oscar Cazares; Sharmila Chatterjee; Pinky Lee; Catherine Strietzel; J. W. Bubolz; Gwyndolen Harburg; Jon Howard; Sol Katzman; Jeremy Sanford; Lindsay Hinck ABSTRACT In the mammary gland, how alveolar progenitor cells are recruited to fuel tissue growth with each estrus cycle and pregnancy remains...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (12): dev199281.
Published: 15 June 2021
...Johanna I. Englund; Alexandra Ritchie; Leander Blaas; Hanne Cojoc; Nalle Pentinmikko; Julia Döhla; Sharif Iqbal; Manuel Patarroyo; Pekka Katajisto ABSTRACT Epithelial attachment to the basement membrane (BM) is essential for mammary gland development, yet the exact roles of specific BM components...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (22): dev169862.
Published: 15 November 2020
...Christine J. Watson; Walid T. Khaled ABSTRACT The mammary gland is a unique tissue and the defining feature of the class Mammalia. It is a late-evolving epidermal appendage that has the primary function of providing nutrition for the young, although recent studies have highlighted additional...
Journal Articles
Journal: Development
Development (2020) 147 (19): dev190744.
Published: 8 October 2020
... a crucial role for RAB6A/A′ in the lactogenic function of the mammary gland and suggest that the trafficking pathways controlled by RAB6A/A′ depend on cell-type specialization and tissue context. RAB6A/A′ have been intensively studied in cultured cells and implicated in several cellular functions...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (5): dev182303.
Published: 11 March 2020
... the postnatal development of mammary gland and influences breast carcinogenesis by binding to the estrogen receptor ERα. ERα acts as a transcription factor but also elicits rapid signaling through a fraction of ERα expressed at the membrane. Here, we have used the C451A-ERα mouse model mutated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (4): dev181552.
Published: 17 February 2020
.... Mammary glands appeared functional at the onset of lactation in mutant mice; however, myoepithelial cell morphology was markedly altered, suggesting cellular compensation mechanisms involving cytoskeleton reorganization. Notably, lactation was not sustained in mutant females, and the glands underwent...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (23): dev185306.
Published: 2 December 2019
...Jakub Sumbal; Zuzana Koledova ABSTRACT Fibroblast growth factor (FGF) signaling is crucial for mammary gland development. Although multiple roles for FGF signaling in the epithelium have been described, the function of FGF signaling in mammary stroma has not been elucidated. In this study, we...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (4): dev160382.
Published: 21 February 2018
.../chloroform/methanol) overnight at room temperature and stained with carmine alum (Stem Cell Technologies), as described ( Chiche et al., 2013 ) or fixed in 4% paraformaldehyde overnight at 4°C. ImageJ was used to determine the fat pad filling percentages. For whole-mount X-gal staining, mammary glands were...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (22): 4103–4113.
Published: 15 November 2017
...Emilia Peuhu; Reetta Virtakoivu; Anja Mai; Anni Wärri; Johanna Ivaska In the mammary gland, vimentin intermediate filaments are expressed in stromal cells and in basal epithelial cell populations, including gland-reconstituting mammary stem cells, with largely undefined functions. Here, we have...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (1): 74–82.
Published: 1 January 2017
...Gillian J. Wilson; Kay D. Hewit; Kenneth J. Pallas; Claire J. Cairney; Kit M. Lee; Christopher A. Hansell; Torsten Stein; Gerard J. Graham Macrophages are important regulators of branching morphogenesis during development and postnatally in the mammary gland. Regulation of macrophage dynamics...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (22): 4236–4248.
Published: 15 November 2016
... , J. L. and Neville , M. C. ( 2007 ). Key stages in mammary gland development. Secretory activation in the mammary gland: it's not just about milk protein synthesis!   Breast Cancer Res.   9 , 204 . 10.1186/bcr1653 Avril-Sassen , S. , Goldstein , L. D. , Stingl , J...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (21): 3956–3968.
Published: 1 November 2016
... of the membrane-anchored matrix metalloproteinases MMP14 (MT1-MMP) and MMP15 (MT2-MMP), which drive epithelial cell invasion by remodeling the extracellular matrix and triggering associated signaling cascades. However, the roles that these proteinases play during mammary gland development in vivo remain undefined...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (6): 983–993.
Published: 15 March 2016
.... and Papaioannou , V. E. ( 2004 ). Dynamic in vivo imaging and cell tracking using a histone fluorescent protein fusion in mice . BMC Biotechnol.   4 , 33 . 10.1186/1472-6750-4-33 Hennighausen , L. and Robinson , G. W. ( 2005 ). Information networks in the mammary gland . Nat. Rev. Mol...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (6): 1028–1042.
Published: 15 March 2015
...Jamie L. Inman; Claire Robertson; Joni D. Mott; Mina J. Bissell The development of the mammary gland is unique: the final stages of development occur postnatally at puberty under the influence of hormonal cues. Furthermore, during the life of the female, the mammary gland can undergo many rounds...
Journal Articles
Journal: Development
Development (2014) 141 (17): 3352–3362.
Published: 1 September 2014
...Xiaohong Zhang; Denisse Martinez; Zuzana Koledova; Guijuan Qiao; Charles H. Streuli; Pengfei Lu FGF signaling is essential for mammary gland development, yet the mechanisms by which different members of the FGF family control stem cell function and epithelial morphogenesis in this tissue...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (16): 3159–3164.
Published: 15 August 2014
... in early lethality. To explore the role of this basally restricted transcription factor in the mammary gland, we generated a cre -inducible mouse model. MMTV- or K14- cre -mediated deletion of Id4 led to a delay in ductal morphogenesis, consistent with previous findings using a germ-line knockout mouse...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (5): 1085–1094.
Published: 1 March 2014
... 12 2013 © 2014. Published by The Company of Biologists Ltd 2014 Apicobasal polarity Breast cancer Epithelial development Mammary gland Mouse Simple epithelial cells are characterized by extensive intercellular junctions and strong polarity along the apicobasal...
Journal Articles
Journal: Development
Development (2013) 140 (5): 1079–1089.
Published: 1 March 2013
... that plays an essential role in ovulation by regulating the expression of the epidermal growth factor-like family of growth factors. Although several studies indicate a role for RIP140 in breast cancer, its role in the development of the mammary gland is unclear. By using RIP140-null and RIP140 transgenic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (1): 117–125.
Published: 1 January 2013
...Emanuela S. Milani; Heike Brinkhaus; Regula Dueggeli; Ina Klebba; Urs Mueller; Michael Stadler; Hubertus Kohler; Matthew J. Smalley; Mohamed Bentires-Alj Tyrosine phosphorylation plays a fundamental role in mammary gland development. However, the role of specific tyrosine phosphatases...
Includes: Supplementary data