.../user-licence-1-1/ Summary: A protocol that efficiently produces neuromesodermal progenitors from a multipotent population with progenitors for a variety of mesodermal derivatives. Embryonic stem cells Neuromesodermal progenitors Axial extension Mammalian development...

...Ram P. Kumar; Soma Ray; Pratik Home; Biswarup Saha; Bhaswati Bhattacharya; Heather M. Wilkins; Hemantkumar Chavan; Avishek Ganguly; Jessica Milano-Foster; Arindam Paul; Partha Krishnamurthy; Russell H. Swerdlow; Soumen Paul ABSTRACT Early mammalian development is crucially dependent...

... and cancer As KLFs play a vital role in mammalian development, stem cell biology, and cellular regeneration, it is not surprising that they have also been implicated in cancer biology. In fact, KLFs are associated with various malignancies (reviewed by Tetreault et al., 2013 ). Mechanistically, KLFs have...

... development. In early mammalian embryos, GATA3 is selectively expressed in the extraembryonic trophoblast lineage and regulates gene expression to promote trophoblast fate. However, trophoblast-specific GATA3 function is dispensable for early mammalian development. Here, using dual conditional knockout mice...

..., equivalent cells form two distinct populations composed of smaller inner cells and larger outer cells. These results reveal a unique feature of early mammalian development: an asymmetry may emerge autonomously in an equivalent population with no need for a priori intrinsic differences. * Authors...