...) that are highly expressed in the testis. Among these, only eIF4E-3 has been characterized genetically. Here, using CRISPR/Cas9 mutagenesis, we determined that eIF4E-5 is essential for male fertility. eIF4E-5 protein localizes to the distal ends of elongated spermatid cysts, and eIF4E-5 mutants exhibit defects...

...-piece thickness in others ( Fig. 6 E). Summary: Analysis of a graded series of KATNB1 loss-of-function models reveals that katanin proteins are required to regulate the vast majority of microtubule-based processes in male germ cell development. Male fertility Male infertility Microtubules...

... of Kpna6 in spermatogenesis and male fertility. We show that ablation of Kpna6 in male mice leads to infertility and has multiple cumulative effects on both germ cells and Sertoli cells. Kpna6-deficient mice exhibit impaired Sertoli cell function, including loss of Sertoli cells and a compromised nuclear...

... are indistinguishable from those of the wild type and male fertility is guaranteed. * Author for correspondence ( renkawit@biologie.uni-marburg.de ) Competing interests The authors declare no competing or financial interests. 22 5 2015 28 11 2015 © 2016. Published by The Company...

... , H. , Polikiewicz , G. , Mahadevaiah , S. K. , Prosser , H. , Mitchell , M. , Bradley , A. , de Rooij , D. G. , Burgoyne , P. S. and Turner , J. M. A. ( 2010 ). Evidence that meiotic sex chromosome inactivation is essential for male fertility . Curr. Biol.   20...

...@ed.ac.uk ) Competing interests The authors declare no competing financial interests. 11 12 2013 24 3 2014 © 2014. Published by The Company of Biologists Ltd 2014 Diphtheria Leydig Male fertility Peritubular myoid Sertoli Testis Mouse Sertoli cells (SCs...

.... 2006 Fertilization Male fertility Acrosome Paternal effect mutations Drosophila Studies of fertilization have revealed the universal importance of membrane events to prepare and coordinate the gametes and ensure their successful union. These events have been most extensively studied...

.... Drosophila Pox neuro Enhancer Courtship behavior Male fertility PNS CNS Appendages The Pox neuro ( Poxn ) gene of Drosophila is a member of the Pax gene family, encoding transcription factors with a DNA-binding paired domain ( Bopp et al.,1989 ). It plays an important role...