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Keywords: Macrophage
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Journal Articles
Journal: Development
Development (2022) 149 (8): dev200270.
Published: 3 May 2022
...Christopher Zhe Wei Lee; Florent Ginhoux ABSTRACT Although best known for their phagocytic and immunological functions, macrophages have increasingly been recognised as key players in the development, homeostasis and regeneration of their host tissues. Early during development, macrophages...
Journal Articles
Journal: Development
Development (2022) 149 (8): dev199803.
Published: 29 April 2022
... to injury. Here, we monitored osteoblast-immune cell interactions in bone, a tissue which is particularly difficult to in vivo image in tetrapod species. Ablation of individual osteoblasts leads to recruitment of neutrophils and macrophages in varying numbers, depending on the extent of the initial insult...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (8): dev200237.
Published: 25 March 2022
... expansion of tissue macrophage populations in most organs. Bone marrow cells from Csf1r E631K/+ mice were resistant to CSF1 stimulation in vitro , and Csf1r E631K/+ mice were unresponsive to administration of a CSF1-Fc fusion protein, which expanded tissue macrophage populations in controls. In the brain...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (8): dev199636.
Published: 26 October 2021
... injury model to investigate inflammatory and regenerative responses in larval zebrafish using heartbeat-synchronised light-sheet fluorescence microscopy. We used this model to test two clinically approved CDK9 inhibitors, AT7519 and flavopiridol, examining their effects on neutrophils, macrophages...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (12): dev187815.
Published: 17 June 2020
...Gillian J. Wilson; Ayumi Fukuoka; Samantha R. Love; Jiwon Kim; Marieke Pingen; Alan J. Hayes; Gerard J. Graham ABSTRACT Macrophages are key regulators of developmental processes, including those involved in mammary gland development. We have previously demonstrated that the atypical chemokine...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (9): dev156000.
Published: 2 May 2019
...Marine Theret; Remi Mounier; Fabio Rossi ABSTRACT The discovery of new non-canonical (i.e. non-innate immune) functions of macrophages has been a recurring theme over the past 20 years. Indeed, it has emerged that macrophages can influence the development, homeostasis, maintenance and regeneration...
Journal Articles
Journal: Development
Development (2017) 144 (21): 3907–3916.
Published: 1 November 2017
...Jennifer Simkin; Mimi C. Sammarco; Luis Marrero; Lindsay A. Dawson; Mingquan Yan; Catherine Tucker; Alex Cammack; Ken Muneoka In mammals, macrophages are known to play a major role in tissue regeneration. They contribute to inflammation, histolysis, re-epithelialization, revascularization and cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (9): 1464–1474.
Published: 1 May 2016
.... Dopamine Macrophage Microglia Nitroreductase Hb9 Olig2 Sox10 In contrast to mammals, adult zebrafish are capable of regenerating neurons in the central nervous system (CNS), including the spinal cord ( Grandel and Brand, 2013 ; Goldman, 2014 ; Becker and Becker, 2015 ; Than-Trong and Bally...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (24): 4229–4238.
Published: 15 December 2010
...Angela C. L. Chua; Leigh J. Hodson; Lachlan M. Moldenhauer; Sarah A. Robertson; Wendy V. Ingman Each ovarian cycle, the mammary gland epithelium rotates through a sequence of hormonally regulated cell proliferation, differentiation and apoptosis. These studies investigate the role of macrophages...
Journal Articles
Journal: Development
Development (2008) 135 (3): 523–532.
Published: 1 February 2008
...Ulrich Tigges; Elizabeth Gore Hyer; Jeffrey Scharf; William B. Stallcup Vessel-like networks are quickly formed in subcutaneous FGF2-supplemented Matrigel plugs by two cell types: NG2 + pericytes and F4/80 + macrophages. Although not detected in these networks until 7 days after plug implantation...
Journal Articles
Journal: Development
Development (2007) 134 (24): 4449–4458.
Published: 15 December 2007
...Sujata Rao; Ivan B. Lobov; Jefferson E. Vallance; Kaoru Tsujikawa; Ichiro Shiojima; Shailaja Akunuru; Kenneth Walsh; Laura E. Benjamin; Richard A. Lang Macrophages have a critical function in the recognition and engulfment of dead cells. In some settings, macrophages also actively signal programmed...
Journal Articles
Journal: Development
Development (2006) 133 (15): 2915–2924.
Published: 1 August 2006
...Sven Huelsmann; Christina Hepper; Daniele Marchese; Christian Knöll; Rolf Reuter In Drosophila embryos, macrophages originate from the cephalic mesoderm and perform a complex migration throughout the entire embryo. The molecular mechanisms regulating this cell migration remain largely unknown. We...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (20): 4955–4962.
Published: 15 October 2003
... ). This might be a developmental adaptation of the EH, which at stage 12 are already differentiated into functional macrophages and are responsible for the removal of apoptotic cells within developing tissues( Abrams et al., 1993 ; Franc et al., 1996 ; Franc, 1999 ; Hartenstein and Jan, 1992 ; Tepass et al...