... were reduced in E9.5 and E10.5 SM22 α -Cre;R26R;Bmpr1a flox/flox embryos, respectively. Knock-down of BMPR1A by RNA interference in human pulmonary artery SMCs reduced MMP2 and MMP9 activity, attenuated serum-induced proliferation, and impaired PDGF-BB-directed migration. RNA interference of MMP2...

... required for the execution of several stereotyped motor axon pathfinding decisions. The Drosophila genome contains only two MMP homologs, Mmp1 and Mmp2 . We isolated Mmp1 in a misexpression screen to identify molecules required for motoneuron development. Misexpression of either MMP inhibits the regulated...

... to develop in either experimental or control MBS solutions for another 18-24 hours until they reached stage 40. The experimental solutions were MBS with 5-75 μM MMP2/MMP9 Inhibitor IV (SB-3CT; Chemicon, Temecula, CA), 100-400 μM of a specific peptide gelatinase inhibitor, cyclic CTTHWGFTLC (cyclic CTT...

... in the Müllerian mesenchyme that culminates in apoptosis of the Müllerian duct epithelium. Presently, the paracrine signal(s) used in this developmental event are undefined. We have identified a member of the matrix metalloproteinase gene family, Mmp2 , as one of the first candidate target genes downstream...