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Jianxin Hu, Michael P. Verzi, Ashley S. Robinson, Paul Ling-Fung Tang, Lisa L. Hua, Shan-Mei Xu, Pui-Yan Kwok, Brian L. Black
Development (2015) 142 (16): 2775–2780.
Published: 15 August 2015
... transcription factor MEF2C is an immediate downstream transcriptional target and effector of Endothelin signaling in the neural crest. We show that Endothelin signaling activates Mef2c expression in the neural crest through a conserved enhancer in the Mef2c locus and that CRISPR-mediated deletion of this Mef2c...
Includes: Supplementary data
Pooja Agarwal, Michael P. Verzi, Thuyen Nguyen, Jianxin Hu, Melissa L. Ehlers, David J. McCulley, Shan-Mei Xu, Evdokia Dodou, Joshua P. Anderson, Maria L. Wei, Brian L. Black
Development (2011) 138 (12): 2555–2565.
Published: 15 June 2011
... and other neural crest defects, including defective innervation of the gut. SOX10 controls neural crest development through interactions with other transcription factors. The MADS box transcription factor MEF2C is an important regulator of brain, skeleton, lymphocyte and cardiovascular development...
Development (2007) 134 (13): 2511–2519.
Published: 1 July 2007
... that zebrafish Mef2d and Mef2c proteins are required redundantly for assembly of myosin-containing thick filaments in nascent muscle fibres, but not for the earlier steps of skeletal muscle fibre differentiation, elongation, fusion or thin filament gene expression. mef2d mRNA and protein is present in myoblasts...
Includes: Supplementary data
Development (2004) 131 (16): 3931–3942.
Published: 15 August 2004
... these processes remain to be determined. The MADS domain transcription factor MEF2C is required for proper formation of the cardiac outflow tract and right ventricle, suggesting a key role in anterior heart field development. Therefore, as a first step toward identifying the transcriptional pathways upstream...
Hanying Chen, Shu Shi, Lourdes Acosta, Weiming Li, Jonathan Lu, Shideng Bao, Zhuang Chen, Zuocheng Yang, Michael D. Schneider, Kenneth R. Chien, Simon J. Conway, Mervin C. Yoder, Laura S. Haneline, Diego Franco, Weinian Shou
Development (2004) 131 (9): 2219–2231.
Published: 1 May 2004
... required for maintaining normal expression levels of several key cardiogenic factors (e.g. NKX2.5 and MEF2C) in the developing myocardium at mid-gestation. Furthermore, BMP10-conditioned medium is able to rescue BMP10-deficient hearts in culture. Our data suggest an important pathway that involves...
Development (2001) 128 (22): 4623–4633.
Published: 15 November 2001
... the expression of muscle-specific genes. To determine the mechanisms that regulate MEF2 gene expression during skeletal muscle development, we analyzed the mouse Mef2c gene for cis -regulatory elements that direct expression in the skeletal muscle lineage in vivo. We describe a skeletal muscle-specific control...