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Keywords: MAPK
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Journal Articles
Journal: Development
Development (2020) 147 (17): dev185678.
Published: 2 September 2020
... – a Wnt suppressor in intestines. Inhibition of mTor signaling by rapamycin partially rescued Erk1/2 depletion-induced intestinal defects and significantly prolonged the lifespan of mutant mice. These data demonstrate that Erk/Mapk signaling functions as a key modulator of Wnt signaling through...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (14): dev164004.
Published: 26 July 2018
... belongs to the mitogen-activated protein kinase (MAPK) family. Following its phosphorylation by Mek5, Erk5 modulates several signaling pathways in a number of cell types. In this study, we demonstrated that Erk5 inactivation in mesenchymal cells causes abnormalities in skeletal development by inducing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (19): 3562–3577.
Published: 1 October 2017
.... Collectively, these findings demonstrate that miR-322 is an unconventional inhibitor of a central signaling pathway in chondrocytes that regulates transient and permanent cartilage homeostasis. MEK Cartilage MAPK miR-322 CRISPR Stabilization Summary: miR-322 is identified...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (10): 1778–1787.
Published: 15 May 2016
... belong to the mitogen-activated protein kinase (MAPK) group of serine/threonine protein kinases. In mammalian cells, the JNK subfamily consists of three isoforms: JNK1, JNK2 and JNK3 (also known as MAPK8, MAPK9 and MAPK10). JNK1 and JNK2 are ubiquitously expressed, whereas JNK3 is specifically expressed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (5): 787–798.
Published: 1 March 2016
... + progenitors at E8.5 results in growth arrest of the junctional zone. TFAP2C regulates its target genes Cdkn1a (previously p21 ) and Dusp6 , which are involved in repression of MAPK signaling. Loss of TFAP2C reduces activation of ERK1/2 in the placenta. Downregulation of Akt 1 and reduced activation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (3): 461–472.
Published: 1 February 2016
... Ltd 2016 Summary: Cross-subclass interaction of EphB2 with ephrin A5 functions upstream of JNK signaling to maintain an adequate pool of progenitor cells to ensure proper closure of the optic fissure. Apoptosis Optic fissure closure Optic cup MAPK Vertebrate eye development...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (9): 1961–1970.
Published: 1 May 2014
... displacement. Expression of specific laterality markers was randomized in embryos expressing NS and LS variants of Shp2. Ciliogenesis and cilia function in Kupffer's vesicle was impaired, likely accounting for the left/right asymmetry defects. Mitogen-activated protein kinase (MAPK) signaling was activated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (9): 1970–1980.
Published: 1 May 2013
... that in Xenopus dorsal tissues FGF and Wnt signaling quell BMP signaling by degrading phosphorylated (P) Smad1/5, the BMP pathway signal transducer, via phosphorylation of the Smad1/5 linker region. We show that in zebrafish FGF/MAPK, but not Wnt/GSK3, phosphorylation of the Smad1/5 linker region localizes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (8): 1645–1654.
Published: 15 April 2013
...′ UTR. Furthermore, PUF-8 suppresses let-60 3′ UTR-mediated expression in the germ cells that are transitioning from the mitotic to meiotic fate. These results reveal that PUF-8-mediated inhibition of the RAS/MAPK pathway is essential for mitotic-to-meiotic fate transition. * Author...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (6): 1240–1249.
Published: 15 March 2013
... open ( aop ) is dispensable for directed tracheal cell migration, but plays a key role in tracheal tip cell fate specification. Whereas aop globally inhibits TC and FC specification, MAPK signaling overcomes this inhibition by triggering degradation of Aop in tip cells. Loss of aop function causes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (2): 289–300.
Published: 15 January 2012
... a novel requirement for FGF/MAPK signaling. Contrary to current models, we demonstrate that FGF is required within the prospective neural crest epiblast during gastrulation and is unlikely to operate through mesodermal tissues. Additionally, we show that FGF/MAPK activity in the prospective neural plate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (5): 885–895.
Published: 1 March 2011
... successive M phases (meiosis I and II) drive two rounds of asymmetric cell division (ACD). However, how the egg limits the number of meioses to just two, thereby preventing gross aneuploidy, is poorly characterized. Here, in urochordate eggs, we show that loss of Mos/MAPK activity is necessary to prevent...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (7): 1283–1293.
Published: 1 April 2008
... the canonical wnt signaling pathway required for axis formation in Xenopus embryos. Cell 120 , 857 -871. Tsang, M. and Dawid, I. B. ( 2004 ). Promotion and attenuation of FGF signaling through the Ras-MAPK pathway. Sci. STKE 2004 , pe17 . Tsang, M., Friesel, R., Kudoh, T. and Dawid, I. B. ( 2002...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (5): 931–940.
Published: 1 March 2008
...Weiyang Shi; Mike Levine Mesodermal tissues arise from diverse cell lineages and molecular strategies in the Ciona embryo. For example, the notochord and mesenchyme are induced by FGF/MAPK signaling, whereas the tail muscles are specified autonomously by the localized determinant, Macho-1. A unique...
Journal Articles
Journal: Development
Development (2007) 134 (6): 1203–1219.
Published: 15 March 2007
... -11. Gomez, A. R., Lopez-Varea, A., Molnar, C., de la Calle-Mustienes, E., Ruiz-Gomez, M., Gomez-Skarmeta, J. L. and de Celis, J. F. ( 2005 ). Conserved cross-interactions in Drosophila and Xenopus between Ras/MAPK signaling and the dual-specificity phosphatase MKP3 . Dev. Dyn. 232 , 695 -708...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (21): 4355–4365.
Published: 1 November 2006
.... Using mouse and Xenopus eggs, we show that IP 3 R1 is phosphorylated during both maturation and the first cell cycle at a MPM2-detectable epitope(s),which is known to be a target of kinases controlling the cell cycle. In vitro phosphorylation studies reveal that MAPK/ERK2, one of the M-phase kinases...
Journal Articles
Journal: Development
Development (2005) 132 (19): 4273–4283.
Published: 1 October 2005
... by signals from underlying paraxial mesoderm without concomitant induction of an ambivalent neural/mesodermal cell state. The stem zone is a site of FGF/MAPK signalling and we show that although FGF alone does not mimic paraxial mesoderm signals, it is directly required in epiblast cells for stem zone...
Journal Articles
Journal: Development
Development (2004) 131 (20): 4955–4964.
Published: 15 October 2004
... for prostatic regeneration. * Author for correspondence (e-mail: kurita@itsa.ucsf.edu ) 2 8 2004 © 2004. 2004 Androgen Mucin Epithelial differentiation Apoptosis Urogenital sinus Cell linage MAPK Src The prostate contains two major epithelial cell types: luminal and basal...
Journal Articles
Journal: Development
Development (2004) 131 (6): 1289–1298.
Published: 15 March 2004
...-activated protein kinase (MAPK) but SHH does not itself activate MAPK. Instead, constitutive activity of FGFR maintains a basal level of phosphorylated MAPK that is absolutely required for the OLIG2- and OLP-inducing activities of SHH. Stimulating the MAPK pathway with a retrovirus encoding constitutively...
Journal Articles
Journal: Development
Development (2003) 130 (21): 5169–5177.
Published: 1 November 2003
...-hybrid screen with MAPK as a bait, we have recently identified MISS (MAPK interacting and spindle stabilizing) which controls mouse oocyte metaphase II spindle stability. Using the same screen, we identify another MAPK partner, DOC1R (Deleted in oral cancer one related), a murine homologue of a potential...