.... Arteriovenous malformation RASA1 Blood vessel MAPK Cumming School of Medicine, University of Calgary http://dx.doi.org/10.13039/100012866 Canadian Institutes of Health Research http://dx.doi.org/10.13039/501100000024 Heart and Stroke Foundation of Canada http://dx.doi.org...

...Sara J. Knowles; April M. Stafford; Tariq Zaman; Kartik Angara; Michael R. Williams; Jason M. Newbern; Daniel Vogt ABSTRACT RAS/MAPK gene dysfunction underlies various cancers and neurocognitive disorders. Although the roles of RAS/MAPK genes have been well studied in cancer, less is known about...

... – a Wnt suppressor in intestines. Inhibition of mTor signaling by rapamycin partially rescued Erk1/2 depletion-induced intestinal defects and significantly prolonged the lifespan of mutant mice. These data demonstrate that Erk/Mapk signaling functions as a key modulator of Wnt signaling through...

... belongs to the mitogen-activated protein kinase (MAPK) family. Following its phosphorylation by Mek5, Erk5 modulates several signaling pathways in a number of cell types. In this study, we demonstrated that Erk5 inactivation in mesenchymal cells causes abnormalities in skeletal development by inducing...

.../ Summary: miR-322 is identified as an unconventional inhibitor of a central signaling pathway in mouse chondrocytes that regulates transient and permanent cartilage homeostasis through MEK1 production and suppression of ERK1/2 phosphorylation MEK Cartilage MAPK miR-322 CRISPR Stabilization...

... 2015 11 3 2016 © 2016. Published by The Company of Biologists Ltd 2016 Summary: In mice, JNK and WNT4 antagonistically regulate E-cadherin expression and oocyte-oocyte adhesion during germline cyst breakdown and primordial follicle formation. JNK E-cadherin Cadherin 1 MAPK...

... + progenitors at E8.5 results in growth arrest of the junctional zone. TFAP2C regulates its target genes Cdkn1a (previously p21 ) and Dusp6 , which are involved in repression of MAPK signaling. Loss of TFAP2C reduces activation of ERK1/2 in the placenta. Downregulation of Akt 1 and reduced activation...

... Ltd 2016 Summary: Cross-subclass interaction of EphB2 with ephrin A5 functions upstream of JNK signaling to maintain an adequate pool of progenitor cells to ensure proper closure of the optic fissure. Apoptosis Optic fissure closure Optic cup MAPK Vertebrate eye development...

... displacement. Expression of specific laterality markers was randomized in embryos expressing NS and LS variants of Shp2. Ciliogenesis and cilia function in Kupffer's vesicle was impaired, likely accounting for the left/right asymmetry defects. Mitogen-activated protein kinase (MAPK) signaling was activated...

... that in Xenopus dorsal tissues FGF and Wnt signaling quell BMP signaling by degrading phosphorylated (P) Smad1/5, the BMP pathway signal transducer, via phosphorylation of the Smad1/5 linker region. We show that in zebrafish FGF/MAPK, but not Wnt/GSK3, phosphorylation of the Smad1/5 linker region localizes...

...′ UTR. Furthermore, PUF-8 suppresses let-60 3′ UTR-mediated expression in the germ cells that are transitioning from the mitotic to meiotic fate. These results reveal that PUF-8-mediated inhibition of the RAS/MAPK pathway is essential for mitotic-to-meiotic fate transition. * Author...

... open ( aop ) is dispensable for directed tracheal cell migration, but plays a key role in tracheal tip cell fate specification. Whereas aop globally inhibits TC and FC specification, MAPK signaling overcomes this inhibition by triggering degradation of Aop in tip cells. Loss of aop function causes...

... a novel requirement for FGF/MAPK signaling. Contrary to current models, we demonstrate that FGF is required within the prospective neural crest epiblast during gastrulation and is unlikely to operate through mesodermal tissues. Additionally, we show that FGF/MAPK activity in the prospective neural plate...

... successive M phases (meiosis I and II) drive two rounds of asymmetric cell division (ACD). However, how the egg limits the number of meioses to just two, thereby preventing gross aneuploidy, is poorly characterized. Here, in urochordate eggs, we show that loss of Mos/MAPK activity is necessary to prevent...

... . * Author for correspondence (e-mail: idawid@nih.gov ) 29 1 2008 © 2008. 2008 Fgf8 MAPK Neural crest Slug Wnt3a Xenopus laevis Leucine-rich repeats protein Animal cap DNA microarray The neural crest (NC) arises at the border between the neural plate and the epidermis...

...Weiyang Shi; Mike Levine Mesodermal tissues arise from diverse cell lineages and molecular strategies in the Ciona embryo. For example, the notochord and mesenchyme are induced by FGF/MAPK signaling, whereas the tail muscles are specified autonomously by the localized determinant, Macho-1. A unique...

... 11 1 2007 © 2007. 2007 Ascidian tadpoles Apoptosis Ci-sushi Metamorphosis MAPK During embryonic development, apoptosis plays a central role in the successful outcome of the developmental program, and has been studied using genetic and cell-biological means in many model...

.... Using mouse and Xenopus eggs, we show that IP 3 R1 is phosphorylated during both maturation and the first cell cycle at a MPM2-detectable epitope(s),which is known to be a target of kinases controlling the cell cycle. In vitro phosphorylation studies reveal that MAPK/ERK2, one of the M-phase kinases...

... by signals from underlying paraxial mesoderm without concomitant induction of an ambivalent neural/mesodermal cell state. The stem zone is a site of FGF/MAPK signalling and we show that although FGF alone does not mimic paraxial mesoderm signals, it is directly required in epiblast cells for stem zone...

... for prostatic regeneration. * Author for correspondence (e-mail: kurita@itsa.ucsf.edu ) 2 8 2004 © 2004. 2004 Androgen Mucin Epithelial differentiation Apoptosis Urogenital sinus Cell linage MAPK Src The prostate contains two major epithelial cell types: luminal and basal...