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Keywords: MAP kinase
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Journal Articles
Journal: Development
Development (2016) 143 (15): 2732–2740.
Published: 1 August 2016
... MAP kinase RASSF7 Cortical development Disrupted in schizophrenia 1 ( DISC1 ) was originally identified in a chromosome translocation (1; 11) (q42.1; q14.3) in a Scottish family with a high susceptibility to schizophrenia and several other psychiatric disorders ( Hayashi-Takagi et al., 2010...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (3): 431–437.
Published: 1 February 2015
... the activation of the intracellular signaling pathways downstream of LIF in ESCs with different genetic backgrounds. We found that the JAK-Stat3 pathway was dominantly activated in ESCs derived from ‘permissive’ mouse strains (129Sv and C57BL6), whereas the MAP kinase pathway was hyperactivated in ESCs from ‘non...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (13): 2746–2754.
Published: 1 July 2013
.... Published by The Company of Biologists Ltd 2013 EGFR signaling ETS proteins Pointed MAP kinase Eye development Development of all multicellular organisms is dictated by a handful of signaling pathways that transmit information from the extracellular milieu and neighboring cells...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2009) 136 (10): 1687–1696.
Published: 15 May 2009
... MAP kinase p90Rsk Starfish eggs The transition from oocyte to embryo is essential for initiating embryonic development. A key event in this transition is the start of the embryonic mitotic cell cycle by fertilization. Prior to this start, the cell cycle in oocytes is generally arrested...
Journal Articles
Journal: Development
Development (2008) 135 (11): 1913–1922.
Published: 1 June 2008
... signaling. Hepatol. Res. 37 , 957 -965. Gabay, L., Seger, R. and Shilo, B. Z. ( 1997a ). In situ activation pattern of Drosophila EGF receptor pathway during development. Science 277 , 1103 -1106. Gabay, L., Seger, R. and Shilo, B. Z. ( 1997b ). MAP kinase in situ activation atlas during...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (15): 2751–2759.
Published: 1 August 2007
... stages before compaction have remained unclear. Here, we show that extracellular signal regulated kinase (ERK) mitogen-activated protein (MAP) kinase function is required for early embryonic cell division before compaction. Our analysis demonstrates that inhibition of ERK activation in late two-cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (21): 4341–4353.
Published: 1 November 2006
...Eric Röttinger; Jenifer Croce; Guy Lhomond; Lydia Besnardeau; Christian Gache; Thierry Lepage Studies in Caenorhabditis elegans and vertebrates have established that the MAP kinase-related protein NLK counteracts Wnt signalling by downregulating the transcription factor TCF. Here, we present...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (11): 2189–2200.
Published: 1 June 2006
... of TGFβ and MAPK signalling pathways. All the Smads contain a cluster of ERK consensus sites in the linker domain and MAP kinase-dependent phosphorylation of these sites has been shown to downregulate their activity( Kretzschmar et al., 1997 ; Pera et al., 2003 ) (reviewed by Massagué, 2003 ). We...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (9): 1823–1830.
Published: 1 May 2006
... 2006 © 2006. 2006 Meiotic cell cycle G1 arrest Fertilization Mos MAP kinase p90 Rsk Parthenogenesis Starfish oocytes The female gamete of most animals arrests in the meiotic cell cycle while awaiting fertilization, and thus parthenogenesis is prevented...
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2005) 132 (14): 3175–3184.
Published: 15 July 2005
... of the intestinal nuclei is unchanged in the sma-5 mutant. The sma-5 gene is expressed in intestine,excretory cell and hypodermis, and encodes homologs of a mammalian MAP kinase BMK1/ERK5/MAPK7, which was reported to control cell cycle and cell proliferation. Expression of the sma-5 gene in hypodermis is important...
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2001) 128 (21): 4329–4338.
Published: 1 November 2001
..., but integration is likely to be achieved at least partly by cytoplasmic signal transduction networks. Work in other systems ( Drosophila tracheae, MDCK models) suggests that the mitogen-activated protein (MAP) kinase pathway might be important to epithelial branching. We have investigated the role of the MAP...
Journal Articles
Journal: Development
Development (2001) 128 (8): 1403–1414.
Published: 15 April 2001
...James A. Lorenzen; Scott E. Baker; Fabienne Denhez; Michael B. Melnick; Danny L. Brower; Lizabeth A. Perkins ABSTRACT The initiation of gene expression in response to Drosophila receptor tyrosine kinase signaling requires the nuclear import of the MAP kinase, D-ERK. However, the molecular details...
Journal Articles
Journal Articles
Journal: Development
Development (2000) 127 (17): 3769–3776.
Published: 1 September 2000
... this cell fate choice. * Author for correspondence (e-mail: shayashi@lab.nig.ac.jp ) 20 06 2000 09 08 2000 © 2000 by Company of Biologists 2000 Limb Cell fate Cross-talk MAD MAP kinase Drosophila It has been shown that development of insect wings and legs...
Journal Articles
Journal: Development
Development (2000) 127 (3): 631–641.
Published: 1 February 2000
..., the calcium oscillations also continue indefinitely. Finally, in oocytes that contain low mitogen- activated protein (MAP) kinase activity and elevated CDK activity, the sperm-triggered calcium oscillations are again prolonged. We conclude that the CDK activity of the ascidian oocyte can be regarded...