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Keywords: Lymphatic
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Journal Articles
Journal: Development
Development (2022) 149 (4): dev199667.
Published: 21 February 2022
... microscope systems. We demonstrate the utility of this new system by nearly day-long observation of neutrophil recruitment to a wound area in living double-transgenic adult casper zebrafish with fluorescently labeled neutrophils and lymphatic vessels, as well as intubating and imaging the same fish...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (1): dev200065.
Published: 4 January 2022
... malformations. It is still unknown whether meningeal lymphatic networks, which are patterned alongside the venous sinuses, are also affected. We now show that the growth and expansion of meningeal lymphatics are perturbed in Twist1 craniosynostosis models. Changes to the local meningeal environment, including...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (11): dev167098.
Published: 3 June 2021
...Mathias Francois; Anna Oszmiana; Natasha L. Harvey ABSTRACT The lymphatic vasculature is an integral component of the cardiovascular system. It is essential to maintain tissue fluid homeostasis, direct immune cell trafficking and absorb dietary lipids from the digestive tract. Major advances in our...
Journal Articles
Journal: Development
Development (2017) 144 (3): 507–518.
Published: 1 February 2017
... the formation of intersegmental arteries by primary angiogenesis and Vegfc is essential for secondary angiogenesis, giving rise to veins and lymphatics. Vegfd has been largely thought of as dispensable for vascular development in vertebrates. Here, we generated a zebrafish vegfd mutant by genome editing. vegfd...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (20): 3785–3795.
Published: 15 October 2016
...Masahiro Shin; Ira Male; Timothy J. Beane; Jacques A. Villefranc; Fatma O. Kok; Lihua J. Zhu; Nathan D. Lawson Vascular endothelial growth factor C (Vegfc) activates its receptor, Flt4, to induce lymphatic development. However, the signals that act downstream of Flt4 in this context in vivo remain...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (6): 924–935.
Published: 15 March 2016
...Jonathan Semo; Julian Nicenboim; Karina Yaniv The lymphatic system is a blind-ended network of vessels that plays important roles in mediating tissue fluid homeostasis, intestinal lipid absorption and the immune response. A profound understanding of the development of lymphatic vessels, as well...
Journal Articles
Journal: Development
Development (2014) 141 (13): 2680–2690.
Published: 1 July 2014
...Jonathan W. Astin; Michael J. L. Haggerty; Kazuhide S. Okuda; Ludovic Le Guen; June P. Misa; Alisha Tromp; Benjamin M. Hogan; Kathryn E. Crosier; Philip S. Crosier Lymphangiogenesis is a dynamic process that involves the sprouting of lymphatic endothelial cells (LECs) from veins to form lymphatic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (7): 1497–1506.
Published: 1 April 2013
...Jacques A. Villefranc; Stefania Nicoli; Katie Bentley; Michael Jeltsch; Georgia Zarkada; John C. Moore; Holger Gerhardt; Kari Alitalo; Nathan D. Lawson Vascular endothelial growth factor C (Vegfc) is a secreted protein that guides lymphatic development in vertebrate embryos. However, its role...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (13): 2381–2391.
Published: 1 July 2012
...Kazuhide S. Okuda; Jonathan W. Astin; June P. Misa; Maria V. Flores; Kathryn E. Crosier; Philip S. Crosier We have generated novel transgenic lines that brightly mark the lymphatic system of zebrafish using the lyve1 promoter. Facilitated by these new transgenic lines, we generated a map...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (17): 3847–3857.
Published: 1 September 2011
... the trunk vasculature to the space between the dorsal aorta (DA) and the posterior cardinal vein (PCV) to form the main vessel of the lymphatic system: the thoracic duct (TD) ( Bussmann et al., 2010 ; Yaniv et al., 2006 ). Prior to the formation of the PAC along the HMS, however, motoneurons extend axons...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (9): 1703–1712.
Published: 1 May 2007
... expression in Gata2 -GFP knock-in embryos. Using founder transgenic analyses, we identified a Gata2 endothelium enhancer in the fourth intron and found that Gata2 regulation by this enhancer is restricted to the endocardial, lymphatic and vascular endothelium. Whereas disruption of three ETS-binding motifs...