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Keywords: Lung
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Journal Articles
Journal: Development
Development (2022) 149 (1): dev199505.
Published: 10 January 2022
... 2021 9 12 2021 © 2022. Published by The Company of Biologists Ltd 2022 Summary: Wnts from the lung epithelium are crucial for the differentiation of the surrounding mesenchyme during early postnatal alveologenesis. Alveologenesis Bronchopulmonary dysplasia Lung Wnt Wntless...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (4): dev181560.
Published: 20 February 2020
... for the development of most organs, including the lung. Despite extensive work detailing effects of RA deficiency in early lung morphogenesis, little is known about how RA regulates late gestational lung maturation. Here, we investigate the role of the RA catabolizing protein Cyp26b1 in the lung. Cyp26b1 is highly...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (2): dev166454.
Published: 16 January 2019
...Thomas Volckaert; Tingting Yuan; Jie Yuan; Eistine Boateng; Seantel Hopkins; Jin-San Zhang; Victor J. Thannickal; Reinhard Fässler; Stijn P. De Langhe ABSTRACT Organ growth and tissue homeostasis rely on the proliferation and differentiation of progenitor cell populations. In the developing lung...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (21): dev163105.
Published: 9 November 2018
...Leah B. Nantie; Randee E. Young; Wyatt G. Paltzer; Yan Zhang; Randy L. Johnson; Jamie M. Verheyden; Xin Sun ABSTRACT Lung growth to its optimal size at birth is driven by reiterative airway branching followed by differentiation and expansion of alveolar cell types. How this elaborate growth...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (15): dev165399.
Published: 1 August 2018
... mechanisms of cell fate regulation through niche-derived cues, with a particular focus on epithelial stem cells of the mammalian skin, intestine and lung. We discuss a spectrum of niche-derived biochemical, mechanical and architectural inputs that define stem cell states during morphogenesis, homeostasis...
Journal Articles
Journal: Development
Development (2018) 145 (9): dev163014.
Published: 11 May 2018
...Mei-I Chung; Melissa Bujnis; Christina E. Barkauskas; Yoshihiko Kobayashi; Brigid L. M. Hogan ABSTRACT The bone morphogenetic protein (BMP) signaling pathway, including antagonists, functions in lung development and regeneration of tracheal epithelium from basal stem cells. Here, we explore its...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (21): 3879–3893.
Published: 1 November 2017
... of pluripotent stem cells (PSCs) through stimulation of developmental signaling pathways can generate mature somatic cell types for basic laboratory studies or regenerative therapies. However, there has been significant uncertainty regarding a method to separately derive lung versus thyroid epithelial lineages...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (19): 3547–3561.
Published: 1 October 2017
... role in lung epithelium, consistent with lack of HOXA5 expression in this cell layer. In contrast, ablation of Hoxa5 in mesenchyme perturbed trachea development, lung epithelial cell differentiation and lung growth. Further, deletion of Hoxa5 in motor neurons resulted in abnormal diaphragm innervation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (9): 1600–1606.
Published: 1 May 2017
... gene inactivation reveals roles for Fgf10 and Fgfr2 in establishing a normal pattern of epithelial branching in the mouse lung . Dev. Dyn.   238 , 1999 - 2013 . 10.1002/dvdy.22032 Balasooriya , G. I. , Johnson , J.-A. , Basson , M. A. and Rawlins , E. L. ( 2016 ). An FGFR1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (23): 4139–4150.
Published: 1 December 2015
...; Saverio Bellusci Lipid-containing alveolar interstitial fibroblasts (lipofibroblasts) are increasingly recognized as an important component of the epithelial stem cell niche in the rodent lung. Although lipofibroblasts were initially believed merely to assist type 2 alveolar epithelial cells in surfactant...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (1): 108–117.
Published: 1 January 2015
...Melinda E. Snitow; Shanru Li; Michael P. Morley; Komal Rathi; Min Min Lu; Rachel S. Kadzik; Kathleen M. Stewart; Edward E. Morrisey The development of the lung epithelium is regulated in a stepwise fashion to generate numerous differentiated and stem cell lineages in the adult lung. How...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (3): 502–513.
Published: 1 February 2014
...Michael Herriges; Edward E. Morrisey The respiratory system, which consists of the lungs, trachea and associated vasculature, is essential for terrestrial life. In recent years, extensive progress has been made in defining the temporal progression of lung development, and this has led to exciting...
Journal Articles
Journal: Development
Development (2012) 139 (23): 4365–4373.
Published: 1 December 2012
...Mitsuru Morimoto; Ryuichi Nishinakamura; Yumiko Saga; Raphael Kopan In the developing lung, it is thought that the terminal buds of elongating airways contain a population of multipotent epithelial progenitors. As the bronchial tree extends, descendants of these cells give rise to lineage...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (16): 3010–3020.
Published: 15 August 2012
... transcriptional repressors Osr1 and Osr2 are redundantly required for Xenopus lung specification in a molecular pathway linking foregut pattering by FGFs to Wnt-mediated lung specification and RA-regulated lung bud growth. FGF and RA signals are required for robust osr1 and osr2 expression in the foregut endoderm...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (14): 2500–2509.
Published: 15 July 2012
...Shanru Li; Yi Wang; Yuzhen Zhang; Min Min Lu; Francesco J. DeMayo; Joseph D. Dekker; Philip W. Tucker; Edward E. Morrisey The molecular pathways regulating cell lineage determination and regeneration in epithelial tissues are poorly understood. The secretory epithelium of the lung is required...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (15): 3169–3177.
Published: 1 August 2011
...Yongjun Yin; Fen Wang; David M. Ornitz Fibroblast growth factor (FGF) 9 is a secreted signaling molecule that is expressed in lung mesothelium and epithelium and is required for lung development. Embryos lacking FGF9 show mesenchymal hypoplasia, decreased epithelial branching and, by the end...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (7): 1235–1245.
Published: 1 April 2011
.... We show that the miR302/367 cluster is a target of the transcription factor Gata6 in mouse lung endoderm and regulates multiple aspects of early lung endoderm progenitor development. miR302/367 is expressed at early stages of lung development, but its levels decline rapidly as development proceeds...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (5): 947–957.
Published: 1 March 2011
... in a murine Dachsous homolog, Dchs1 . Analysis of the phenotypes of Dchs1 mutant mice and comparisons with Fat4 mutant mice identify requirements for these genes in multiple organs, including the ear, kidney, skeleton, intestine, heart and lung. Dchs1 and Fat4 single mutants and Dchs1 Fat4 double mutants have...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (6): 1049–1058.
Published: 15 March 2008
... of Lrp6. Rspo2 Tg/Tg mice had severe malformations of laryngeal-tracheal cartilages, limbs and palate, and lung hypoplasia consistent with sites of Rspo2 expression. Rspo2 Tg/Tg lung defects were associated with reduced branching, a reduction in TOPGAL reporter activity, and reduced expression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (1): 189–198.
Published: 1 January 2007
...%) Numbers recovered at 2 weeks (percent) 55 (38%) 49 (33%) 32 (22%) 10 (7%) † Author for correspondence (e-mail: emorrise@mail.med.upenn.edu ) * These authors contributed equally to this work 27 10 2006 © 2007. 2007 GATA Nkx Transcription factor Synergy Lung...
Includes: Supplementary data