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Keywords: Lumen
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Journal Articles
Journal: Development
Development (2018) 145 (9): dev162123.
Published: 30 April 2018
... reflects unlimited biliary morphogenesis rather than proliferative expansion. Our studies suggest that NF2 normally limits biliary morphogenesis by coordinating lumen expansion and cell architecture. This work provides fundamental insight into how biliary fate and tubulogenesis are coordinated during...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (19): 3511–3520.
Published: 1 October 2017
...Lei Gao; Zhufeng Yang; Chitkale Hiremath; Susan E. Zimmerman; Blake Long; Paul R. Brakeman; Keith E. Mostov; David M. Bryant; Katherine Luby-Phelps; Denise K. Marciano In many types of tubules, continuity of the lumen is paramount to tubular function, yet how tubules generate lumen continuity...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (5): 1110–1119.
Published: 1 March 2014
...Ashley L. Alvers; Sean Ryan; Paul J. Scherz; Jan Huisken; Michel Bagnat The formation of a single lumen during tubulogenesis is crucial for the development and function of many organs. Although 3D cell culture models have identified molecular mechanisms controlling lumen formation in vitro...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (24): 4870–4880.
Published: 15 December 2013
... with lumens that are generated through poorly understood cellular rearrangements. Here, we show that creation of the hair follicle lumen is mediated by early outward movement of keratinocytes from within the cores of developing hair buds. These migratory keratinocytes express keratin 79 (K79) and stream out...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (14): 2851–2855.
Published: 15 July 2013
... regulatory events driving the cell shape changes that produce tubes of specific dimensions. An overview of the current understanding of the molecular processes and physical forces involved in tubulogenesis is presented in this review and the accompanying poster. Lumenal space is also captured to form...
Journal Articles
Journal: Development
Development (2013) 140 (8): 1774–1784.
Published: 15 April 2013
... that become restricted to an apical domain, coinciding with lumen formation. Once lumen formation has been initiated, elongation occurs by simultaneous extension and additional de novo lumen generation. We demonstrate that lumen formation and elongation require afadin, a nectin adaptor protein implicated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (24): 5415–5427.
Published: 15 December 2011
...Na Xu; Gaiana Bagumian; Michael Galiano; Monn Monn Myat Generation and maintenance of proper lumen size is important for tubular organ function. We report on a novel role for the Drosophila Rho1 GTPase in control of salivary gland lumen size through regulation of cell rearrangement, apical domain...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (18): 3119–3128.
Published: 15 September 2010
...) in the embryo. We show that the primary lumen elongates along cell junctions between at least two endothelial cells during embryonic angiogenesis. Moesin1-EGFP is enriched around structures that resemble intracellular vacuoles, which fuse with the luminal membrane during expansion of the primary lumen. Analysis...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (5): 795–804.
Published: 1 March 2010
...Jennifer H. Gutzman; Hazel Sive We demonstrate that in the zebrafish hindbrain, cell shape, rhombomere morphogenesis and, unexpectedly, brain ventricle lumen expansion depend on the contractile state of the neuroepithelium. The hindbrain neural tube opens in a specific sequence, with initial...
Includes: Multimedia, Supplementary data