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Keywords: Lineage tracing
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Journal Articles
Journal: Development
Development (2022) 149 (8): dev199803.
Published: 29 April 2022
... osteoblast ablation induces recruitment of tissue-resident macrophages, which are required for osteoblasts to repopulate the lesion site, through glucocorticoid signaling and by a release of reactive oxygen species. Osteoblast Macrophage Glucocorticoid Reactive oxygen species Lineage tracing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (8): dev200139.
Published: 24 January 2022
... hematopoietic stem cells (HSCs), many TLCs are of fetal origin and poorly generated from adult HSCs. Here, we sought to further understand murine TLC development and the roles of Flk2 and IL7Rα, two cytokine receptors with known function in traditional lymphopoiesis. Using Flk2- and Il7r-Cre lineage tracing, we...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (18): dev198994.
Published: 9 September 2021
... and applications to lineage tracing in live-imaging data and outline software methodologies that can be applied to various cell-tracking challenges. * These authors contributed equally to this work ‡ Author for correspondence ( kmcdole@mrc-lmb.cam.ac.uk ) Competing interests The authors...
Journal Articles
Journal: Development
Development (2021) 148 (5): dev187534.
Published: 10 March 2021
... systems showing replacement of mechanosensory cells can provide mechanistic insights into developing new regenerative therapies. Here, we developed lineage tracing systems to reveal the generation of mechanosensory neurons in the Johnston's organ (JO) of intact adult Drosophila , which are the functional...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (24): dev197590.
Published: 16 December 2020
... work defines compartmentalized multiple SC/progenitor populations of the mouse eye in homeostasis and their behavioral changes in response to injury. The SC potential of the central cornea is a subject of debate. Our lineage tracing study showed that K14 CreER+ and Dlx1 CreER+ cells in the central...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (20): dev193193.
Published: 23 October 2020
... and migration routes. By marking progenitor cells, one can observe their subsequent locations and the cell types into which they differentiate. Here, we review major discoveries in neural crest lineage tracing from a historical perspective. We discuss how advancing technologies have refined lineage-tracing...
Journal Articles
Journal: Development
Development (2020) 147 (19): dev192807.
Published: 9 October 2020
..., that are maintained in a lineage-restricted manner during homeostasis or after mild injuries. Glandular regeneration following a near complete loss of secretory cells, however, may involve cellular plasticity, although the mechanism and extent of such plasticity remain unclear. Here, by combining lineage-tracing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (13): dev180950.
Published: 13 July 2020
.../progenitor cells. However, the precise stem cell niche organization, the intermediate steps and the endogenous regulators of postnatal hypothalamic neurogenesis remain elusive. Quantitative lineage-tracing in vivo revealed that conditional deletion of fibroblast growth factor 10 (Fgf10) from Fgf10-expressing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (9): dev184481.
Published: 12 May 2020
... by equal base composition, 5′ G sequence, minimal likelihood of residing in the functional genome, minimal off targets and ease of amplification. We validate multiple high-quality endogenous CRISPR/Cas9 arrays , demonstrating their utility for lineage tracing. Our pragmatically scalable technique thus can...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2020) 147 (5): dev184085.
Published: 11 March 2020
... is roughly complementary. (N) Scatter plots showing the number of neuropil-glia in indicated lineages in a hemisphere (areas 1,3 and 4) and in a brain (area 2) at the 50% pupa stage. Red lines indicate mean. Quantification of the lineage-tracing experiment shown in Fig. 6 A,A′,D,D′. Neuropil-glia, number...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (2): dev181032.
Published: 17 January 2020
... allele to lineage trace AMFs, we demonstrate that most AMFs are developmentally cleared during alveologenesis. Lung mesenchyme also contains other poorly described cell types, including alveolar lipofibroblasts (ALF). We show that Gli1:CreERT2 marks both AMFs as well as ALFs, and lineage tracing shows...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (20): dev180224.
Published: 23 October 2019
... are self-sustained in adult mice by unipotent lineage-restricted SCs. The spatiotemporal regulation of SC fate and the switch from multipotency to unipotency remain poorly characterised. Here, by combining lineage tracing, whole-tissue imaging, clonal analysis and proliferation kinetics, we uncover...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (14): dev176180.
Published: 22 July 2019
... lineage tracing of cells with an expression history of IL7Rα, a marker exclusively associated with the lymphoid lineage in adult hematopoiesis. Surprisingly, we found that Il7r-Cre labeled fetal-derived, adult trMacs. Labeling was almost complete in some tissues and partial in others. The putative...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (12): dev169730.
Published: 27 June 2019
... questions that can be addressed using single cell dynamic lineage tracing. Genetic or epigenetic changes can be used as an alternative to imaging-based techniques to infer lineage. A number of research groups have leveraged these naturally occurring changes to trace lineages, both in development...
Journal Articles
Journal: Development
Development (2018) 145 (19): dev168658.
Published: 11 October 2018
... and cholangiocytes to the mature liver. Lineage tracing Liver Definitive endoderm Hepatoblast Mouse The definitive endoderm (DE), the embryonic germ layer that produces the gut tube as well as the parenchyma of the liver, pancreas, lung, thymus and thyroid, arises by embryonic day (E) 7.5...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (17): dev166801.
Published: 17 August 2018
... subcutaneous adipocytes closest to the forelimb display a greater proportion of Prx1 lineage tracing than those more dorsally positioned ( Sanchez-Gurmaches et al., 2015 ). Taken as a whole, these data support the notion that PLPM establishes adipocyte lineages that populate subcutaneous, internal and visceral...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (14): dev164079.
Published: 25 July 2018
... to this work. ¶ Authors for correspondence ( bethan.lloyd-lewis@curie.fr ; f.davis@uq.edu.au ; cjw53@cam.ac.uk ) Competing interests The authors declare no competing or financial interests. 3 2 2018 19 6 2018 Summary: Neutral, low-density lineage tracing of proliferative...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (10): dev160184.
Published: 17 May 2018
.... As development proceeds, these clusters expand and further contribute to the growing lymphatic system. Lineage tracing and analyses of Gata2 -deficient mice confirmed that these clusters are endothelial in origin. Furthermore, ectopic expression of Vegfc in the vasculature increased the number of PROX1-positive...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (16): dev162305.
Published: 16 April 2018
... lineage tracing of human trophoblast nor live imaging are possible because of the optical density of the CCCs and the floating nature of the villi. We used a thymidine analogue pulse-chase strategy as a preliminary attempt to study the differentiation potential of the cells in this proliferative niche...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev147793.
Published: 9 January 2018
... and are transplanted into wild-type hosts proliferate and differentiate into derivatives of all germ layers and into germ cells (this study). Strikingly, GESTALT-mediated long-term lineage tracing revealed that these cells survive to adulthood in a wild-type host. Together, these observations indicate that Nanog has...
Includes: Supplementary data