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Keywords: Limb
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Journal Articles
Journal: Development
Development (2023) 150 (10): dev201101.
Published: 29 May 2023
... found that muscle bundle shapes and attachment sites were significantly altered in embryos with Scx -lineage cell ablation. Muscles in the forelimb showed impaired bundle separation and limb girdle muscles distally dislocated from their insertion sites. Scx -lineage cells were required for post-fusion...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (3): dev201038.
Published: 15 February 2023
... genome editing to generate a mouse allelic series. Embryos mosaic for humanized Fzd2 W553* knock-in exhibited cleft palate and shortened limbs, consistent with patient phenotypes. We also generated two germline mouse alleles with small deletions: Fzd2 D3 and Fzd2 D4 . Homozygotes for each allele exhibit...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (18): dev200702.
Published: 22 September 2022
...Axel H. Newton; Sarah M. Williams; Andrew T. Major; Craig A. Smith ABSTRACT The lateral plate mesoderm (LPM) is a transient tissue that produces a diverse range of differentiated structures, including the limbs. However, the molecular mechanisms that drive early LPM specification and development...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (17): dev177956.
Published: 11 September 2020
...Caitlin McQueen; Matthew Towers ABSTRACT The vertebrate limb continues to serve as an influential model of growth, morphogenesis and pattern formation. With this Review, we aim to give an up-to-date picture of how a population of undifferentiated cells develops into the complex pattern of the limb...
Journal Articles
Journal: Development
Development (2019) 146 (14): dev167700.
Published: 22 July 2019
...Alberto Joven; Ahmed Elewa; András Simon ABSTRACT Salamanders have been hailed as champions of regeneration, exhibiting a remarkable ability to regrow tissues, organs and even whole body parts, e.g. their limbs. As such, salamanders have provided key insights into the mechanisms by which cells...
Journal Articles
Journal: Development
Development (2019) 146 (10): dev171421.
Published: 15 May 2019
... in a partially overlapping fashion that roughly corresponds to the three MMP streams ( Fig. 3 ). In limb bud-deficient chicken embryos and fin field-deficient medaka embryos, limb-level Lbx1 is still expressed, indicating that the limb is not required for MMP specification ( Alvares et al., 2003 ; Tani...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (2): dev156554.
Published: 17 January 2018
... that expression of m Nfia might be affecting this IHH/PTHrP regulatory loop. We analyzed the expression pattern of PTHrP in m Nfia- expressing chick limbs. As expected, loss of IHH resulted in reduced expression of PTHrP in RCAS-m Nfia -infected joints ( Fig. 4 D,D′, black arrow). Bonilla-Claudio et...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2017) 144 (11): 2009–2020.
Published: 1 June 2017
...Endika Haro; Billy A. Watson; Jennifer M. Feenstra; Luke Tegeler; Charmaine U. Pira; Subburaman Mohan; Kerby C. Oberg Lmx1b is a homeodomain transcription factor responsible for limb dorsalization. Despite striking double-ventral (loss-of-function) and double-dorsal (gain-of-function) limb...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (4): 601–611.
Published: 15 February 2017
...Matthew Nguyen; Pankhuri Singhal; Judith W. Piet; Sandra J. Shefelbine; Malcolm Maden; S. Randal Voss; James R. Monaghan Salamanders are capable of regenerating amputated limbs by generating a mass of lineage-restricted cells called a blastema. Blastemas only generate structures distal...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2016) 143 (19): 3514–3521.
Published: 1 October 2016
... with Turing-like properties. However, as four of the five digits of the mouse limb are morphologically similar in terms of phalangeal pattern, it has been suggested that self-organization alone could be sufficient. Here, we show that inhibition of Shh signalling at a specific stage of chick wing development...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (19): 3481–3490.
Published: 1 October 2016
...Jean-François Denis; Fadi Sader; Samuel Gatien; Éric Villiard; Anie Philip; Stéphane Roy Axolotls are unique among vertebrates in their ability to regenerate tissues, such as limbs, tail and skin. The axolotl limb is the most studied regenerating structure. The process is well characterized...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (14): 2548–2560.
Published: 15 July 2016
... regulator in limb patterning. Harnessing an osteogenic lineage-specific Shox2 inactivation approach we show that despite widespread Shox2 expression in multiple cell lineages, lack of the stylopod observed upon Shox2 deficiency is a specific result of Shox2 loss of function in the osteogenic lineage. ChIP...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (24): 4340–4350.
Published: 15 December 2015
... to express a high number of genes that are associated with chondrogenesis, including several extracellular matrix proteins and transcription factors that regulate chondrogenesis. Therefore, we compared regions of putative SOX9 DNA binding between E12.5 heart valves and E12.5 limb buds. We identified context...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2014) 141 (21): 4194–4198.
Published: 1 November 2014
...Julia E. VanderMeer; Robin P. Smith; Stacy L. Jones; Nadav Ahituv The limb is widely used as a model developmental system and changes to gene expression patterns in its signaling centers, notably the zone of polarizing activity (ZPA) and the apical ectodermal ridge (AER), are known to cause limb...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (19): 3683–3696.
Published: 1 October 2014
... identified. We have undertaken a transcriptome analysis of mouse limb tendon cells that were isolated at different stages of development based on scleraxis ( Scx ) expression. Microarray comparisons allowed us to establish a list of genes regulated in tendon cells during mouse limb development...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (18): 3605–3611.
Published: 15 September 2014
..., the addition of nuclei in limb muscles is three times more rapid than in trunk and is tightly associated with fiber growth. A complex interaction takes place in the trunk, where primary myotome cells from the medial somite border rarely fuse to one another, but readily do so with anterior and posterior border...
Includes: Supplementary data
Journal Articles