...Patrick Narbonne; Richard Roy In C. elegans , reduced insulin-like signalling induces developmental quiescence, reproductive delay and lifespan extension. We show here that the C. elegans orthologues of LKB1 and AMPK cooperate during conditions of reduced insulin-like signalling to establish cell...

... are grossly normal in morphology and development, grow longer to be almost twice as big,and have weak egg-laying defects and extended lifespan. All the four mutants have a mutation in the egl-4 gene. We show that the egl-4 gene encodes cGMP-dependent protein kinases. egl-4 promoter::gfp fusion genes...

... of gene expression. ¶Author for correspondence (e-mail: Siegfried.Hekimi@mcgill.ca ) 20 7 2001 © 2001. 2001 clk-2 TEL2 Caenorhabditis elegans Maternal effect Telomere length Lifespan The development of sexually reproducing organisms is affected by their parents...