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Keywords: Lens
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Journal Articles
Journal: Development
Development (2018) 145 (8): dev161018.
Published: 23 April 2018
... profound cardiac and trunk muscle dystrophy, along with lens abnormalities, caused by abrupt terminal differentiation of cardiomyocyte, myoblast and lens fiber cells. Loss of ddx39ab hindered splicing of mRNAs encoding epigenetic regulatory factors, including members of the KMT2 gene family, leading...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (4): 708–719.
Published: 15 February 2017
...) The average rate of lens epithelial expansion in three wild-type and habrk3 mutant lenses. Averages and s.d. are indicated by horizontal and vertical bars, respectively. Although values of cell division period in the habrk3 mutant are variable, profiles were similar to those shown in C and D. Student's t-test...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2016) 143 (21): 3994–4002.
Published: 1 November 2016
... in the nuclei of lens cells. Moreover, Lhx2 mRNA was also never detected in either control or Chx10-Cre;Lhx2 lox/lox lenses (insets in Fig. 2 B-G). As previous work has shown that Lhx2 expression is absent in the lens at all stages of ocular development ( Hägglund et al., 2011 ), we conclude that the Lhx2...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2016) 143 (2): 356–366.
Published: 15 January 2016
... and lens fiber was performed as described ( Sugiyama and McAvoy, 2012 ). In brief, lenses were dissected from eyeballs. A small tear was made on the posterior capsule. Capsule was then peered off along the tears and lens fiber mass was collected. The remaining capsule containing lens epithelium...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (10): 1850–1859.
Published: 15 May 2015
... and explant assays. Our results provide evidence that at blastula stages, BMP signals inhibit the acquisition of eye-field character, but from neural tube/optic vesicle stages, BMP signals from the lens are crucial for the maintenance of eye-field character, inhibition of dorsal telencephalic cell identity...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (23): 4432–4447.
Published: 1 December 2014
... ). Moreover, conditional inactivation of p53 in the lens resulted in the accumulation of proliferating, undifferentiated cells in the lens fiber cell compartment ( Wiley et al., 2011 ). Overexpression of E2F1 or E2F2 in postmitotic transgenic lenses prompted re-entry into the cell cycle ( Chen et al., 2000...
Journal Articles
Journal: Development
Development (2013) 140 (20): 4237–4245.
Published: 15 October 2013
... of hexagonal cells. The mechanism that controls this morphogenesis from randomly packed cuboidal epithelial cells to highly organized hexagonal fiber cells remains unknown. In Epha2 -/- mouse lenses, equatorial epithelial cells fail to form precisely aligned meridional rows; moreover, the lens fulcrum, where...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (7): 1573–1582.
Published: 1 April 2013
... nuclei and in the fiber cells of the WT lens ( Fig. 1C ). By contrast, MAPK1 staining was absent in the Mapk1 CKO lens ( Fig. 1D ). Immunohistochemistry against MAPK1/3 revealed uniform immune reactivity in the epithelial layer and in the fiber cells at a lower level in WT lenses ( Fig. 1E...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (2): 359–372.
Published: 15 January 2012
... on a complex set of cell movements coordinated between the prospective neural retina, retinal pigmented epithelium (RPE) and lens. Optic vesicle evagination persists for longer than expected; cells move in a pinwheel pattern during optic vesicle elongation and retinal precursors involute around the rim...
Includes: Multimedia, Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2010) 137 (3): 405–415.
Published: 1 February 2010
... in the developing eye, otic vesicle, branchial arches ( Fig. 6D,F ) and in the lens at stage 25 ( Fig. 6F ). Pax6 -injected embryos produced regions of intense Shroom3 expression that were likely to represent ectopic lenses ( Fig. 6E,G , arrowheads). The relatively intense in situ labeling of ectopic Shroom3...
Journal Articles
Journal: Development
Development (2009) 136 (23): 3895–3906.
Published: 1 December 2009
..., but development arrests prior to optic cup formation in both the optic neuroepithelium and lens ectoderm. This is accompanied by failure to maintain or initiate the expression patterns of optic-vesicle-patterning and lens-inducing determinants. Of the signaling pathways examined, only BMP signaling is noticeably...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (17): 2977–2985.
Published: 1 September 2009
... ). According to tissue recombination experiments( Fujiwara et al., 1994 ), the generation of Pax6 mutant chimeric mice( Collinson et al., 2000 ),lineage-traced ectopic lenses ( Chow et al.,1999 ) and Pax6 conditional deletion( Ashery-Padan et al., 2000 ),Pax6 has an autonomous role in lens development. When...
Journal Articles
Journal: Development
Development (2009) 136 (15): 2567–2578.
Published: 1 August 2009
... the regulatory interactions of these two intrinsic factors with the canonical Wnt pathway. Analysis of the Pax6-deficient lenses revealed a requirement for Pax6 in cell cycle exit and differentiation into lens fiber cells. In addition, Pax6 disruption led to apoptosis of lens epithelial cells. We show that Pax6...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (2): 249–258.
Published: 15 January 2008
... and analyzed the major enhancer of FoxE3 ( Lens1 ), a gene essential for lens formation that is activated in the presumptive lens ectoderm (PLE) when commitment to the lens fate occurs. Deletion and mutation analyses of the enhancer based on comparison of Xenopus and mammalian sequences and in vitro...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (24): 4933–4944.
Published: 15 December 2006
... of phospho-Erk and ERM were also downregulated in Ndst1 -mutant lenses. Taken together, these results establish an important role of Ndst1 function in FGF signaling during lens development. * Author for correspondence (e-mail: xz4@iupui.edu ) 4 10 2006 © 2006. 2006 Ndst HSPG BMP...
Journal Articles
Journal Articles
Journal: Development
Development (2005) 132 (20): 4437–4448.
Published: 15 October 2005
... -defective lenses lose Foxe3 expression, placing Foxe3 downstream of Sip1. In the Sip1 -defective lens, β-crystallin-expressing immature lens fiber cells were produced, but γ-crystallin-expressing mature fiber cells were absent, indicating the requirement for Sip1 activity in lens fiber maturation. A 6.2 kb...
Includes: Supplementary data