... of the Notch pathway activation and the different regulatory levels that control the pathway. We then describe several developmental processes where Notch is crucial for coordinating differentiation. These examples include processes that are largely based on lateral inhibition mechanisms giving rise...

... component of lateral inhibition mechanism by inhibiting Notch activity. In addition, D1ICD promotes neurogenesis in a Notch signaling-independent manner. We show that D1ICD binds to Erk1/2 in neural crest stem cells and inhibits the phosphorylation of Erk1/2. In summary, our results indicate that D1ICD...

...Juan C. Luna-Escalante; Pau Formosa-Jordan; Marta Ibañes ABSTRACT During metazoan development, Notch signaling drives spatially coordinated differentiation by establishing communication between adjacent cells. This occurs through either lateral inhibition, in which adjacent cells acquire distinct...

...Nara Guisoni; Rosa Martinez-Corral; Jordi Garcia-Ojalvo; Joaquín de Navascués Cell fate determination by lateral inhibition via Notch/Delta signalling has been extensively studied. Most formalised models consider Notch/Delta interactions in fields of cells, with parameters that typically lead...

... in the fly notum as a model system to explore the regulatory and functional coupling of cell cycle progression and cell fate decision-making. The pattern of bristles and intervening epithelial cells (ECs) becomes established through Notch-mediated lateral inhibition during G2 phase of the cell cycle...

...Elena Chrysostomou; Jonathan E. Gale; Nicolas Daudet The formation of the salt-and-pepper mosaic of hair cells and supporting cells in the sensory epithelia of the inner ear is regulated by Notch signalling and lateral inhibition, but the dynamics of this process and precise mode of action of delta...

...Pau Formosa-Jordan; Marta Ibañes; Saúl Ares; José María Frade Signaling mediated by the Delta/Notch system controls the process of lateral inhibition, known to regulate neurogenesis in metazoans. Lateral inhibition takes place in equivalence groups formed by cells having equal capacity...

...' by facilitating the reorganization of cells into epithelial rosettes and by initiating atoh1a expression. Expression of atoh1a gives proneuromast cells the potential to become sensory hair cells, and lateral inhibition mediated by Delta-Notch signaling restricts atoh1a expression to a central cell. We show...

... activity, but rather is regulated downstream of proneural genes that are widely expressed by neural progenitors. These findings suggest that Lfng acts in a feedback loop downstream of proneural genes, which, by promoting Notch activation, maintains the sensitivity of progenitors to lateral inhibition...

... suggest that this heterogeneity represents the process by which effective lateral inhibition leads to diversification of progenitors into cells that become specialized to deliver or receive Delta signals, where trans and cis interactions with Notch play differential roles in DeltaD endocytosis...

... a three-cell `R8 equivalence group' through repression of ato by the homeodomain transcription factor Rough (Ro). A second model proposes that lateral inhibition is sufficient to select a single R8 from an equipotent group of cells called the intermediate group (IG). Here, we provide new evidence...

... a prerequisite role of Dll1 in neuronal differentiation. These results strongly support the notion that lateral inhibition of Notch signaling indeed operates in the developing mammalian brain and contributes to the selection of differentiating cells among uncommitted NPCs. The Notch signaling pathway plays...

... and Eda are thought to be placode activators, Dkks and BMPs (in particular Bmp4) are generally regarded as placode inhibitors that mediate lateral inhibition in neighboring cells. The best characterized mathematical model to explain the periodic patterning of hair follicles is the reaction-diffusion...

... in the Arabidopsis epidermis is regulated by a lateral inhibition mechanism that relies on interactions between transcription factors. However, it is unclear how temporal- or organ-specific differences in epidermal patterning are achieved. Here we identify TRICHOMELESS1 (TCL1) as a new and major single-repeat MYB...

...Nicolas Daudet; Linda Ariza-McNaughton; Julian Lewis Notch signalling is well-known to mediate lateral inhibition in inner ear sensory patches, so as to generate a balanced mixture of sensory hair cells and supporting cells. Recently, however, we have found that ectopic Notch activity at an early...

... Lateral inhibition Neuronal diversity is one of the fundamental features of the nervous system. For example, the spinal cord, the simplest part of the vertebrate central nervous system (CNS), has three main classes of neurons - motoneurons,projection neurons and interneurons ( Altman and Bayer...

... , and possibly follistatin, are downstream of Eda-A1 in embryonic skin. Ccn2 Ectodermal dysplasia Lateral inhibition NF-κB Tabby Mouse The first visible sign of ectodermal organ development is the appearance of an ectodermal placode, a local thickening of the epithelium. Formation...

...Rachael Brooker; Katsuto Hozumi; Julian Lewis Each of the sensory patches in the epithelium of the inner ear is a mosaic of hair cells and supporting cells. Notch signalling is thought to govern this pattern of differentiation through lateral inhibition. Recent experiments in the chick suggest...

...Amy E. Kiernan; Ralf Cordes; Raphael Kopan; Achim Gossler; Thomas Gridley The mammalian auditory sensory epithelium, the organ of Corti, contains sensory hair cells and nonsensory supporting cells arranged in a highly patterned mosaic. Notch-mediated lateral inhibition is the proposed mechanism...

...Chrysoula Pitsouli; Christos Delidakis Lateral inhibition is a pattern refining process that generates single neural precursors from a field of equipotent cells and is mediated via Notch signaling. Of the two Notch ligands Delta and Serrate, only the former was thought to participate...