1-20 of 25
Keywords: Lateral inhibition
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
Journal: Development
Development (2021) 148 (19): dev193664.
Published: 04 October 2021
... component of lateral inhibition mechanism by inhibiting Notch activity. In addition, D1ICD promotes neurogenesis in a Notch signaling-independent manner. We show that D1ICD binds to Erk1/2 in neural crest stem cells and inhibits the phosphorylation of Erk1/2. In summary, our results indicate that D1ICD...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev154807.
Published: 10 January 2018
...Juan C. Luna-Escalante; Pau Formosa-Jordan; Marta Ibañes ABSTRACT During metazoan development, Notch signaling drives spatially coordinated differentiation by establishing communication between adjacent cells. This occurs through either lateral inhibition, in which adjacent cells acquire distinct...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (7): 1177–1186.
Published: 01 April 2017
...Nara Guisoni; Rosa Martinez-Corral; Jordi Garcia-Ojalvo; Joaquín de Navascués Cell fate determination by lateral inhibition via Notch/Delta signalling has been extensively studied. Most formalised models consider Notch/Delta interactions in fields of cells, with parameters that typically lead...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (13): 2305–2310.
Published: 01 July 2016
... in the fly notum as a model system to explore the regulatory and functional coupling of cell cycle progression and cell fate decision-making. The pattern of bristles and intervening epithelial cells (ECs) becomes established through Notch-mediated lateral inhibition during G2 phase of the cell cycle...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (20): 3764–3774.
Published: 15 October 2012
...Elena Chrysostomou; Jonathan E. Gale; Nicolas Daudet The formation of the salt-and-pepper mosaic of hair cells and supporting cells in the sensory epithelia of the inner ear is regulated by Notch signalling and lateral inhibition, but the dynamics of this process and precise mode of action of delta...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (13): 2321–2329.
Published: 01 July 2012
...Pau Formosa-Jordan; Marta Ibañes; Saúl Ares; José María Frade Signaling mediated by the Delta/Notch system controls the process of lateral inhibition, known to regulate neurogenesis in metazoans. Lateral inhibition takes place in equivalence groups formed by cells having equal capacity...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (20): 3477–3487.
Published: 15 October 2010
...' by facilitating the reorganization of cells into epithelial rosettes and by initiating atoh1a expression. Expression of atoh1a gives proneuromast cells the potential to become sensory hair cells, and lateral inhibition mediated by Delta-Notch signaling restricts atoh1a expression to a central cell. We show...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (15): 2523–2533.
Published: 01 August 2009
... activity, but rather is regulated downstream of proneural genes that are widely expressed by neural progenitors. These findings suggest that Lfng acts in a feedback loop downstream of proneural genes, which, by promoting Notch activation, maintains the sensitivity of progenitors to lateral inhibition...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (2): 197–206.
Published: 15 January 2009
... suggest that this heterogeneity represents the process by which effective lateral inhibition leads to diversification of progenitors into cells that become specialized to deliver or receive Delta signals, where trans and cis interactions with Notch play differential roles in DeltaD endocytosis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (24): 4071–4079.
Published: 15 December 2008
... a three-cell `R8 equivalence group' through repression of ato by the homeodomain transcription factor Rough (Ro). A second model proposes that lateral inhibition is sufficient to select a single R8 from an equipotent group of cells called the intermediate group (IG). Here, we provide new evidence...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (23): 3849–3858.
Published: 01 December 2008
... interactions, most likely through the Notch-Delta lateral inhibitory signaling pathway, thus contributing to the selection of differentiating cells. * Author for correspondence (e-mail: ygotoh@iam.u-tokyo.ac.jp ) 3 10 2008 © 2008. 2008 Dll1 Notch Lateral inhibition Cell-cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (6): 1019–1028.
Published: 15 March 2008
.... † Author for correspondence (e-mail: irma.thesleff@helsinki.fi ) * These authors contributed equally to this work 7 1 2008 © 2008. 2008 Hair Placode Follicle β-catenin BMP Lateral inhibition Mouse The first sign of hair follicle development is the appearance...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (21): 3873–3882.
Published: 01 November 2007
... in the Arabidopsis epidermis is regulated by a lateral inhibition mechanism that relies on interactions between transcription factors. However, it is unclear how temporal- or organ-specific differences in epidermal patterning are achieved. Here we identify TRICHOMELESS1 (TCL1) as a new and major single-repeat MYB...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (12): 2369–2378.
Published: 15 June 2007
...Nicolas Daudet; Linda Ariza-McNaughton; Julian Lewis Notch signalling is well-known to mediate lateral inhibition in inner ear sensory patches, so as to generate a balanced mixture of sensory hair cells and supporting cells. Recently, however, we have found that ectopic Notch activity at an early...
Journal Articles
Journal: Development
Development (2007) 134 (10): 1911–1920.
Published: 15 May 2007
... that Notch signaling operates at two important levels in vertebrate neuronal specification. First, through lateral inhibition, it regulates the number of neural precursors that give rise to specific subsets of neurons. Second, it specifies sibling cells for different neuronal fates. In zebrafish embryos...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (1): 117–125.
Published: 01 January 2007
...@helsinki.fi ; marja.mikkola@helsinki.fi ) 20 10 2006 © 2007. 2007 Ccn2 Ectodermal dysplasia Lateral inhibition NF-κB Tabby Mouse The first visible sign of ectodermal organ development is the appearance of an ectodermal placode, a local thickening of the epithelium. Formation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (7): 1277–1286.
Published: 01 April 2006
...Rachael Brooker; Katsuto Hozumi; Julian Lewis Each of the sensory patches in the epithelium of the inner ear is a mosaic of hair cells and supporting cells. Notch signalling is thought to govern this pattern of differentiation through lateral inhibition. Recent experiments in the chick suggest...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (19): 4353–4362.
Published: 01 October 2005
...Amy E. Kiernan; Ralf Cordes; Raphael Kopan; Achim Gossler; Thomas Gridley The mammalian auditory sensory epithelium, the organ of Corti, contains sensory hair cells and nonsensory supporting cells arranged in a highly patterned mosaic. Notch-mediated lateral inhibition is the proposed mechanism...
Journal Articles
Journal: Development
Development (2005) 132 (18): 4041–4050.
Published: 15 September 2005
...Chrysoula Pitsouli; Christos Delidakis Lateral inhibition is a pattern refining process that generates single neural precursors from a field of equipotent cells and is mediated via Notch signaling. Of the two Notch ligands Delta and Serrate, only the former was thought to participate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (4): 775–785.
Published: 15 February 2005
... underlying the regulation of neurogenesis and lateral inhibition of boundary cell formation by Wnt1 has a striking similarity to mechanisms at the dorsoventral boundary in the Drosophila wing imaginal disc. Previous studies have revealed important roles of wnt1 at the midbrain/hindbrain organiser ( Liu...