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Keywords: LEF
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Journal Articles
Journal: Development
Development (2005) 132 (24): 5375–5385.
Published: 15 December 2005
...Fei Liu; Olaf van den Broek; Olivier Destrée; Stefan Hoppler Tcf/Lef transcription factors and β-catenin mediate canonical Wnt signalling, which plays remarkably diverse roles in embryonic development,stem cell renewal and cancer progression. To investigate the molecular mechanisms allowing...
Journal Articles
Journal: Development
Development (2004) 131 (12): 2899–2909.
Published: 15 June 2004
... that act as inhibitors of Wnt target genes. The vertebrate homolog of Drosophila nemo , nemo-like kinase ( Nlk ), can phosphorylate Tcf/Lef proteins and inhibit the DNA-binding ability of β-catenin/Tcf complexes, thereby blocking activation of Wnt targets. By contrast, mutations in a C. elegans homolog...
Journal Articles
Journal: Development
Development (2002) 129 (24): 5743–5752.
Published: 15 December 2002
... in dorsal and ventral Xenopus cells mediated by maternal XTcf3. Development 129 , 4015 -4025. Hsu, S. C., Galceran, J. and Grosschedl, R. ( 1998 ). Modulation of transcriptional regulation by LEF-1 in response to Wnt-1 signaling and association with beta-catenin. Mol. Cell. Biol. 18 , 4807 -4818...