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Keywords: Kinesin-1
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Journal Articles
Journal: Development
Development (2019) 146 (8): dev171579.
Published: 17 April 2019
...) and asymmetric transport in oocytes. The control of spindle length by Ensconsin is Kinesin-1 independent but centrosome separation and oocyte transport require targeting of Kinesin-1 to microtubules by Ensconsin. However, the molecular mechanism used for this targeting remains unclear. Ensconsin contains...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2018) 145 (5): dev158782.
Published: 8 March 2018
... by microtubule motors through the LINC complex in the absence of actomyosin contractility. In contrast to the prevailing view that microtubules are uniformly oriented around the nucleus, we observed that the perinuclear microtubule arrays are of mixed polarity and both cytoplasmic dynein complex and kinesin-1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (17): 2996–3008.
Published: 1 September 2015
... Buc-GFP, accumulates at embryonic cleavage furrows. Furthermore, we show that the maternally expressed zebrafish Kinesin-1 Kif5Ba is a binding partner of Buc and that maternal kif5Ba (M kif5Ba ) plays an essential role in germline specification in vivo. Specifically, M kif5Ba is required to recruit GP...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (1): 218–228.
Published: 1 January 2015
...Meredith H. Wilson; Erika L. F. Holzbaur During skeletal muscle development, nuclei move dynamically through myotubes in a microtubule-dependent manner, driven by the microtubule motor protein kinesin-1. Loss of kinesin-1 leads to improperly positioned nuclei in culture and in vivo . Two models...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (20): 4475–4485.
Published: 15 October 2011
... processes. To identify new genes acting with mig-15 , we screened for genetic enhancers of the mig-15 commissural phenotype and identified the ezrin/radixin/moesin ortholog ERM-1, the kinesin-1 motor UNC-116 and the actin regulator WVE-1 complex. Genetic analysis indicates that mig-15 and erm-1 act...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (6): 1087–1092.
Published: 15 March 2011
..., there were no indications that the IAK autoinhibitory motif acts as a general downregulator of Kinesin-1 in those processes. Time-lapse imaging indicated that neither tail region is needed for fast cytoplasmic streaming in oocytes, which is a non-saltatory bulk transport process driven solely by Kinesin-1...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (16): 2725–2733.
Published: 15 August 2009
... with the kinesin-1 light chain KLC-2, as identified in a yeast two-hybrid screen and confirmed by in vitro assays. UNC-83 interacts with and recruits KLC-2 to the nuclear envelope in a heterologous tissue culture system. Additionally, analysis of mutant phenotypes demonstrated that both KLC-2 and the kinesin-1...
Journal Articles
Journal: Development
Development (2005) 132 (16): 3743–3752.
Published: 15 August 2005
... kinesin-1 is required for all streaming and is constitutively capable of driving fast streaming. Khc mutations that reduce the velocity of kinesin-1 transport in vitro blocked streaming yet still supported posterior localization of oskar mRNA, suggesting that streaming is not essential for the oskar...
Includes: Multimedia, Supplementary data