... is established during kidney development. More specifically, how signals from the kidney influence vessel maturity and patterning remains poorly understood. Netrin 1 (Ntn1) is a secreted ligand that is crucial for vessel and neuronal guidance. Here, we demonstrate that Ntn1 is expressed by Foxd1 + stromal...

...Abhishek Sharma; Marco Meer; Arvydas Dapkunas; Anneliis Ihermann-Hella; Satu Kuure; Seppo J. Vainio; Dagmar Iber; Florence Naillat ABSTRACT Kidneys develop via iterative branching of the ureteric epithelial tree and subsequent nephrogenesis at the branch points. Nephrons form in the cap mesenchyme...

... . 10.1002/ajmg.a.38554 Godin , R. E. , Takaesu , N. T. , Robertson , E. J. and Dudley , A. T. ( 1998 ). Regulation of BMP7 expression during kidney development . Development 125 , 3473 - 3482 . 10.1242/dev.125.17.3473 Hartwig , S. , Ho , J. , Pandey , P...

... these cells come from as well as their heterogeneity, and reflect on how this information may improve human kidney organoid models. Summary: This Review describes the role of the stroma in mammalian in vivo kidney development and the importance of understanding stromal contributions to induced...

...Adam Packard; William H. Klein; Frank Costantini ABSTRACT Ret signaling promotes branching morphogenesis during kidney development, but the underlying cellular mechanisms remain unclear. While Ret -expressing progenitor cells proliferate at the ureteric bud tips, some of these cells exit the tips...

... mouse and human have been based on knowledge of the molecular basis of kidney development in mice. Although gene expression during kidney development has been intensely investigated, single cell profiling provides new opportunities to further subsect component cell types and the signalling networks...

...: Conditional inactivation of the polycomb gene Eed in nephron progenitor cells results in their premature loss and prevents normal nephron differentiation beyond the S-shaped tubule stage. Epigenetics Histone methylation Kidney development Nephron Stem cell The nephrons of the metanephric...

... Cheng , H.-T. , Miner , J. H. , Lin , M. , Tansey , M. G. , Roth , K. and Kopan , R. ( 2003 ). Gamma-secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney . Development   130...

.... , Chen , F. , Magella , B. and Potter , S. S. ( 2014 ). Single cell dissection of early kidney development: multilineage priming . Development   141 , 3093 - 3101 . 10.1242/dev.110601 Cheng , H.-T. , Miner , J. H. , Lin , M. , Tansey , M. G. , Roth , K...

.../user-licence-1-1/ Summary: A new method using a protease that works in the cold for cell dissociation dramatically reduces single-cell RNA-seq artifacts, allowing more accurate determination of gene expression in the newborn mouse kidney. Single cell Kidney development Cell...

... throughout mammalian kidney development . Cell Stem Cell   3 , 169 - 181 . 10.1016/j.stem.2008.05.020 Li , D. , Mangan , A. , Cicchini , L. , Margolis , B. and Prekeris , R. ( 2014 ). FIP5 phosphorylation during mitosis regulates apical trafficking and lumenogenesis . EMBO...

... to be required for nephron induction, also instructs the nephron axis such that glomeruli differentiate in regions farthest from the source of Wnt. Kidney development Nephron patterning Glomerulus Mesonephros Chick embryo Wnt signaling The kidney is a vital, bilateral organ that is the central...

.... Published by The Company of Biologists Ltd 2015 Summary: This review discusses recent advances in the directed differentiation of pluripotent cells into kidney tissues, and how these inform our understanding of human renal development. Kidney development Directed differentiation Mesoderm...

... transcription in NPCs. We confirm that WT1 is required for Gas1 expression in kidneys in vivo . Loss of function of GAS1 in vivo results in hypoplastic kidneys with reduced nephron mass due to premature depletion of NPCs. Although kidney development in Gas1 knockout mice progresses normally until E15.5, NPCs...

...Eric W. Brunskill; Joo-Seop Park; Eunah Chung; Feng Chen; Bliss Magella; S. Steven Potter We used a single cell RNA-seq strategy to create an atlas of gene expression patterns in the developing kidney. At several stages of kidney development, histologically uniform populations of cells give rise...

... of Biologists Ltd 2014 Kidney development Nephron progenitor Groucho Odd-skipped Osr1 Six2 Wnt signaling Kidneys play a crucial role in bodily health and homeostasis by filtering metabolic waste and excess fluid from the blood. In mammals, kidney morphogenesis begins...

...Jennifer L. Fetting; Justin A. Guay; Michele J. Karolak; Renato V. Iozzo; Derek C. Adams; David E. Maridas; Aaron C. Brown; Leif Oxburgh Forkhead transcription factors are essential for diverse processes in early embryonic development and organogenesis. Foxd1 is required during kidney development...

... formation/elongation during kidney tubulogenesis. Kidney development Lumen Tubulogenesis Afadin (Mllt4) Polarity Nectin Cadherin Par complex Formation and elongation of epithelial tubules is essential for the structure and function of many organs. Although general...

... ( marco.pontoglio@inserm.fr ; evelyne.fischer@inserm.fr ) Competing interests statement The authors declare no competing financial interests. 26 11 2012 © 2013. Published by The Company of Biologists Ltd 2013 HNF1β MODY5 Notch pathway Kidney development CAKUT Kidney...

... interests statement The authors declare no competing financial interests. 15 12 2011 © 2012. Kidney development Kidney evolution Pharyngeal arch development Zebrafish Plac8 The evolution of animal complexity has fascinated scientists ever since Darwin presented...