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Keywords: Kidney
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Journal Articles
Journal: Development
Development (2022) 149 (10): dev200446.
Published: 16 May 2022
... single cell and bulk RNA-seq, quantitative immunofluorescent lineage/fate tracing, and genetically modified human induced pluripotent stem cells (iPSCs) to revisit this question in developing mouse kidneys and human kidney organoids. We confirmed that Notch signaling is needed for maturation of all...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (15): dev198408.
Published: 10 August 2021
...Elliot A. Perens; Jessyka T. Diaz; Agathe Quesnel; Amjad Askary; J. Gage Crump; Deborah Yelon ABSTRACT Transcriptional regulatory networks refine gene expression boundaries to define the dimensions of organ progenitor territories. Kidney progenitors originate within the intermediate mesoderm (IM...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (10): dev197475.
Published: 25 May 2021
... cardiovascular health throughout life. We show here that, despite its negative effects on kidney growth, genetic increase of GDNF prolongs the nephrogenic program beyond its normal cessation. Multi-stage mechanistic analysis revealed that excess GDNF maintains nephron progenitors and nephrogenesis through...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (23): dev191973.
Published: 14 December 2020
...Brooke E. Chambers; Eleanor G. Clark; Allison E. Gatz; Rebecca A. Wingert ABSTRACT A functional vertebrate kidney relies on structural units called nephrons, which are epithelial tubules with a sequence of segments each expressing a distinct repertoire of solute transporters. The transcriptiona`l...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (21): dev189183.
Published: 22 June 2020
... Wallingford ABSTRACT Laminin alpha 5 (LAMA5) is a member of a large family of proteins that trimerise and then polymerise to form a central component of all basement membranes. Consequently, the protein plays an instrumental role in shaping the normal development of the kidney, skin, neural tube, lung...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev172387.
Published: 10 July 2019
... and fixed as described previously ( Westerfield, 1993 ; Kimmel et al., 1995 ). Knowledge about the terminal differentiation programs of each nephron segment has central importance for understanding kidney disease and to advance regenerative medicine. Human BOFS is associated with the occurrence...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (8): dev168294.
Published: 29 April 2019
...Caramai N. Kamei; Thomas F. Gallegos; Yan Liu; Neil Hukriede; Iain A. Drummond ABSTRACT Zebrafish kidneys use resident kidney stem cells to replace damaged tubules with new nephrons: the filtration units of the kidney. What stimulates kidney progenitor cells to form new nephrons is not known. Here...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (5): dev172361.
Published: 7 March 2019
...Santhosh V. Kumar; Pei X. Er; Kynan T. Lawlor; Ali Motazedian; Michelle Scurr; Irene Ghobrial; Alexander N. Combes; Luke Zappia; Alicia Oshlack; Edouard G. Stanley; Melissa H. Little ABSTRACT Kidney organoids have potential uses in disease modelling, drug screening and regenerative medicine...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2018) 145 (16): dev164038.
Published: 30 August 2018
...Rajasree Menon; Edgar A. Otto; Austin Kokoruda; Jian Zhou; Zidong Zhang; Euisik Yoon; Yu-Chih Chen; Olga Troyanskaya; Jason R. Spence; Matthias Kretzler; Cristina Cebrián ABSTRACT The mammalian kidney develops through reciprocal interactions between the ureteric bud and the metanephric mesenchyme...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (24): 4704–4719.
Published: 15 December 2017
...Audrey Desgrange; Claire Heliot; Ilya Skovorodkin; Saad U. Akram; Janne Heikkilä; Veli-Pekka Ronkainen; Ilkka Miinalainen; Seppo J. Vainio; Silvia Cereghini Kidney development depends crucially on proper ureteric bud branching giving rise to the entire collecting duct system. The transcription...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (22): 4148–4158.
Published: 15 November 2017
...Sijo Mathew; Riya J. Palamuttam; Glenda Mernaugh; Harini Ramalingam; Zhenwei Lu; Ming-Zhi Zhang; Shuta Ishibe; David R. Critchley; Reinhard Fässler; Ambra Pozzi; Charles R. Sanders; Thomas J. Carroll; Roy Zent Kidney collecting system development requires integrin-dependent cell-extracellular...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (6): 1113–1117.
Published: 15 March 2017
... coverslip and the spacers adjust the thickness, enabling the tissue to grow for up to 12 days. Thus, the kidney rudiment and the organoids can adjust to the limited z -directional space and yet advance the process of kidney morphogenesis, enabling long-term time-lapse and high-resolution confocal imaging...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (1): 106–114.
Published: 1 January 2017
.... Sections were permeabilised in 0.2% Triton X-100/PBS, blocked in 10% goat serum and incubated with the indicated primary antibodies [anti-kidney 4A6.2C10, European Xenopus Resource Centre; anti-axolotl p53 ( Yun et al., 2013 ) 1:200] overnight. In all cases, anti-mouse or anti-rabbit HRP-conjugated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (21): 3907–3913.
Published: 1 November 2016
...Eunah Chung; Patrick Deacon; Sierra Marable; Juhyun Shin; Joo-Seop Park During nephrogenesis, multipotent mesenchymal nephron progenitors develop into distinct epithelial segments. Each nephron segment has distinct cell types and physiological function. In the current model of kidney development...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (15): 2574–2585.
Published: 1 August 2015
...Yaopan Mao; Philippa Francis-West; Kenneth D. Irvine Formation of the kidney requires reciprocal signaling among the ureteric tubules, cap mesenchyme and surrounding stromal mesenchyme to orchestrate complex morphogenetic events. The protocadherin Fat4 influences signaling from stromal to cap...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (6): 1180–1192.
Published: 15 March 2015
... are bound to promoters of key renal developmental regulators and that HDAC activity is required for embryonic kidney gene expression. However, the existence of many HDAC isoforms in embryonic kidneys raises questions concerning the possible specificity or redundancy of their functions. We report here...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (6): 1193–1202.
Published: 15 March 2015
...; Gd, Gartner's duct; Kd, kidney; Ms, metanephros; Ov, ovary; Te, testis; Wd, Wolffian duct. Fig. 5. Notch1 labeling pattern in the reproductive system. (A-E) Whole-mount staining of gonads from male (A-C) and female (D-E) embryos of indicated age and genotype. (F) X-gal staining of an ovary from P53...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (10): 2064–2074.
Published: 15 May 2014
...Wiebke Cizelsky; Aleksandra Tata; Michael Kühl; Susanne J. Kühl Proper development of nephrons is essential for kidney function. β-Catenin-independent Wnt signaling through Fzd8, Inversin, Daam1, RhoA and Myosin is required for nephric tubule morphogenesis. Here, we provide a novel mechanism...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (2): 346–354.
Published: 15 January 2014
...Scott C. Boyle; Zhenyi Liu; Raphael Kopan Mesangial cells are specialized pericyte/smooth muscle cells that surround and constrain the vascular network within the glomerulus of the kidney. They are derived from the stromal mesenchyme, a progenitor population distinct from nephron stem cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (22): 4565–4573.
Published: 15 November 2013
...Mor Grinstein; Ronit Yelin; Doris Herzlinger; Thomas M. Schultheiss Kidneys remove unwanted substances from the body and regulate the internal body environment. These functions are carried out by specialized cells (podocytes) that act as a filtration barrier between the internal milieu...