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Keywords: Joint
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Journal Articles
Journal: Development
Development (2022) 149 (11): dev196220.
Published: 6 June 2022
...Azim Pothiawala; Berke E. Sahbazoglu; Bryan K. Ang; Nadine Matthias; Guangsheng Pei; Qing Yan; Brian R. Davis; Johnny Huard; Zhongming Zhao; Naoki Nakayama ABSTRACT It has been established in the mouse model that during embryogenesis joint cartilage is generated from a specialized progenitor cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (2): dev193409.
Published: 25 January 2021
...Joanna Smeeton; Natasha Natarajan; Arati Naveen Kumar; Tetsuto Miyashita; Pranidhi Baddam; Peter Fabian; Daniel Graf; J. Gage Crump ABSTRACT The regulated expansion of chondrocytes within growth plates and joints ensures proper skeletal development through adulthood. Mutations in the transcription...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (4): dev167452.
Published: 28 February 2019
...Shai Eyal; Sarah Rubin; Sharon Krief; Lihi Levin; Elazar Zelzer ABSTRACT Sesamoid bones are small auxiliary bones that form near joints and contribute to their stability and function. Thus far, providing a comprehensive developmental model or classification system for this highly diverse group...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (2): dev156554.
Published: 17 January 2018
... cartilage marker COL2A1 ( Fig. 5 F,F′) and the absence of joint-specific markers SFRP2 , ENPP2 and GDF5 ( Fig. 5 G-I′) in the putative joint region cells (black arrows). The existing data indicating that loss of Gata3 expression is associated with the downregulation of expression of 16...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (15): 2798–2809.
Published: 1 August 2017
...Lucy H. Brunt; Katie Begg; Erika Kague; Stephen Cross; Chrissy L. Hammond Joint morphogenesis requires mechanical activity during development. Loss of mechanical strain causes abnormal joint development, which can impact long-term joint health. Although cell orientation and proliferation are known...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (13): 2765–2775.
Published: 1 July 2013
...James T. Nichols; Luyuan Pan; Cecilia B. Moens; Charles B. Kimmel The evolution of joints, which afford skeletal mobility, was instrumental in vertebrate success. Here, we explore the molecular genetics and cell biology that govern jaw joint development. Genetic manipulation experiments...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (15): 2507–2517.
Published: 1 August 2010
... in both dorsal and intermediate defects, whereas knockdown of three intermediate-domain restricted genes dlx3b, dlx4b and dlx5a results in intermediate-domain-specific defects. The ventrally expressed gene hand2 patterns ventral identity, in part by repressing dlx3b/4b/5a . The jaw joint...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (12): 2055–2063.
Published: 15 June 2010
... ECM morphology remain elusive. In particular, how dynamic behaviors of ECM-secreting cells, such as shape changes and movements, contribute to ECM morphogenesis is unclear. Strict control of ECM morphology is crucial in the joints, where opposing sides of the skeleton must have precisely reciprocal...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (18): 3695–3707.
Published: 15 September 2006
... joint formation and the essential function of Wnt/β-catenin signaling in regulating chondrocyte survival. More importantly, we found that Wnt and Ihh signaling interact with each other in distinct ways to control osteoblast differentiation, chondrocyte proliferation, hypertrophy, survival and synovial...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (9): 2135–2146.
Published: 1 May 2005
..., the homeobox transcription factors that function during chondrogenesis have been the least well defined. We show here that the homeobox transcription factor Barx2 is expressed in primary mesenchymal condensations, digital rays, developing joints and articular cartilage of the developing limb, suggesting...
Journal Articles
Journal: Development
Development (2004) 131 (1): 229–240.
Published: 1 January 2004
... in C2C12 cells. Thus, CHL2 behaves as a secreted BMP-binding inhibitor. In situ hybridization revealed that CHL2 expression is restricted to chondrocytes of various developing joint cartilage surfaces and connective tissues in reproductive organs. Adult mesenchymal progenitor cells expressed CHL2 , and its...