... resulted in upregulation of jagged 1 in both epidermis and dermis. When Notch was activated in the absence of epidermal jagged 1, jagged 1 was not upregulated in the dermis, and epidermal thickening, blister formation, accumulation of T cells and stromal cells were inhibited. Gene expression profiling...

...-Catenin Notch1 Jagged 1 Inner ear Inner ear development is an excellent example of how a Darwinian `organ of extreme perfection and complication' can arise from simple origins. The inner ear derives from a patch of thickened ectoderm, the otic placode, lying next to the posterior hindbrain...

..., where commitment to hair lineages occurs. Deletion of jagged 1 ( Jag1 ) results in inhibition of the hair growth cycle and conversion of hair follicles into cysts of cells undergoing interfollicular epidermal differentiation. Conversely, activation of Notch in adult epidermis triggers expansion...