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Keywords: Isl1
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Journal Articles
Journal: Development
Development (2022) 149 (21): dev200788.
Published: 25 October 2022
.... In this study, we report that deletion of Isl1 in the mouse mandibular epithelium leads to aglossia due to myoblast migration defects. Isl1 regulates the expression pattern of chemokine ligand 12 ( Cxcl12 ) in the first branchial arch through the Shh/Wnt5a cascade. Cxcl12 + mesenchymal cells in Isl1 ShhCre...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2016) 143 (22): 4182–4192.
Published: 15 November 2016
... of Biologists Ltd 2016 http://www.biologists.com/user-licence-1-1/ Summary: Ldb1 and Ldb2 have both overlapping and specific functions in mouse retinal development, specifically in maintaining the pool of retinal progenitors and for the generation of early-born photoreceptors. Isl1 Ldb1...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2016) 143 (20): 3763–3773.
Published: 15 October 2016
... that the LIM-homeodomain transcription factor Isl1 is expressed in several subpopulations of developing arcuate neurons and plays crucial roles in their fate specification. Mice with conditional deletion of the Isl1 gene in developing hypothalamus display severe deficits in both feeding and linear growth...
Journal Articles
In collection:
Neural development
Journal: Development
Development (2016) 143 (13): 2334–2343.
Published: 1 July 2016
... receptor CXCR4. Interestingly, the absence of CXCR4 signaling in spinal MNs is known to result in improper extension of the axons into the dorsal side of the spinal cord. Here, we report that the MN-specific ISL1-LHX3 complex directly transactivates the Stam1 gene and that STAM1 functions in determining...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (10): 1721–1731.
Published: 15 May 2016
... Highlighted article: In the mouse spinal cord, single-stranded DNA binding proteins are key cofactors in LIM-containing complexes, recruiting histone-modifying enzymes to promote transcription. NLI Ldb1 Isl1 Lhx3 Motor neuron V2a-interneuron Spinal cord ChIP was performed as described...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (17): 3109–3119.
Published: 1 September 2012
... of particular sets of skeletal muscles or visceral organs. MN diversification depends on the coordinated action of several transcriptional regulators including the LIM-HD factor Isl1, which is crucial for MN survival and fate determination. However, how these regulators cooperate to establish each MN subtype...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (22): 3841–3851.
Published: 15 November 2009
... into mature SIN subtypes is regulated by the combinatorial activity of the LIM homeodomain proteins Lhx6, Lhx7 (Lhx8) and Isl1. These studies suggest that a LIM homeodomain transcriptional code confers cell-fate specification and neurotransmitter identity in neuronal subpopulations of the ventral forebrain...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (17): 2923–2932.
Published: 1 September 2009
... proteins Isl1 and Isl2 and LIM-only protein Lmo4 influences the assembly and function of complexes involved in the generation of spinal motor neurons (MNs) and V2a interneurons(INs). Reducing the levels of Islet proteins using a graded series of mutations favored V2a IN differentiation at the expense of MN...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (8): 1575–1585.
Published: 15 April 2006
... that the LIM homeodomain transcription factor islet 1 (Isl1) marks a subset of cardiac progenitors. Here, we perform lineage studies with an Isl1Cre mouse line to demonstrate that Isl1 also marks a subset of limb progenitors. In both cardiac and limb progenitors, Isl1 expression is downregulated as progenitors...