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Keywords: Intestine
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Journal Articles
Journal: Development
Development (2022) 149 (23): dev201251.
Published: 12 December 2022
...Anne M. Bara; Lei Chen; Celina Ma; Julie Underwood; Rebecca S. Moreci; Kaelyn Sumigray; Tongyu Sun; Yarui Diao; Michael Verzi; Terry Lechler ABSTRACT There are fundamental differences in how neonatal and adult intestines absorb nutrients. In adults, macromolecules are broken down into simpler...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (22): dev200325.
Published: 16 November 2022
... protein depletion in the Caenorhabditiselegans embryonic intestine, we found that local and global polarity establishment are temporally and genetically separable. Local polarity is initiated prior to global polarity and is robust to perturbation. PAR-3 is required for global polarization across...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (16): dev200765.
Published: 18 August 2022
... aspects of intestinal morphogenesis: enteric nervous system formation, epithelium structuring, muscle orientation and differentiation, anisotropic growth and the development of myogenic and neurogenic motility. I outline numerous implications of this biomechanical perspective in the etiology and treatment...
Journal Articles
In collection:
Human development
Journal: Development
Development (2022) 149 (8): dev199904.
Published: 3 May 2022
... and reliable tool. Although we primarily focus on recent findings enabled by intestinal organoids co-cultured with lymphocytes, we posit that organoid co-culture systems will support future efforts to disentangle the interactions between a plethora of different cell types throughout development, homeostasis...
Journal Articles
Journal: Development
Development (2021) 148 (23): dev200029.
Published: 10 December 2021
...Aurélien Bidaud-Meynard; Flora Demouchy; Ophélie Nicolle; Anne Pacquelet; Shashi Kumar Suman; Camille N. Plancke; François B. Robin; Grégoire Michaux ABSTRACT The intestinal brush border is made of an array of microvilli that increases the membrane surface area for nutrient processing, absorption...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (21): dev199683.
Published: 9 November 2021
...Cristina Brischetto; Karsten Krieger; Christian Klotz; Inge Krahn; Séverine Kunz; Marina Kolesnichenko; Patrick Mucka; Julian Heuberger; Claus Scheidereit; Ruth Schmidt-Ullrich ABSTRACT Although the role of the transcription factor NF-κB in intestinal inflammation and tumor formation has been...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (5): dev186106.
Published: 9 March 2021
...Meghan Ferguson; Kristina Petkau; Minjeong Shin; Anthony Galenza; David Fast; Edan Foley ABSTRACT Microbial factors influence homeostatic and oncogenic growth in the intestinal epithelium. However, we know little about immediate effects of commensal bacteria on stem cell division programs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (2): dev195339.
Published: 26 January 2021
... resolution in vertebrates. Regeneration Laser ablation ENS Sox10 Intestine References Alunni , A. and Bally-Cuif , L. ( 2016 ). A comparative view of regenerative neurogenesis in vertebrates . Development 143 , 741 - 753 . 10.1242/dev.122796 Asakawa , K...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (19): dev187583.
Published: 12 October 2020
... body axis are beginning to be understood, the mechanisms that shape the asymmetries of individual organs remain less clear. Here, we summarize new evidence challenging century-old ideas about the development of stomach and intestine laterality. We compare classical and contemporary models of asymmetric...
Journal Articles
Journal: Development
Development (2020) 147 (14): dev190330.
Published: 24 July 2020
...Brett R. Lancaster; James D. McGhee ABSTRACT We define a quantitative relationship between the affinity with which the intestine-specific GATA factor ELT-2 binds to cis -acting regulatory motifs and the resulting transcription of asp-1 , a target gene representative of genes involved...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (12): dev188987.
Published: 19 June 2020
... reporter activity correlates with proliferating regions of the brain, haematopoietic tissue and intestine. In the adult gut, the reporter is active in sparse proliferating cells, located at the base of intestinal folds, expressing the stemness marker sox9b and having the morphology of mammalian crypt base...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (8): dev185108.
Published: 12 April 2020
...Robert J. Garriock; Ravindra B. Chalamalasetty; JianJian Zhu; Mark W. Kennedy; Amit Kumar; Susan Mackem; Terry P. Yamaguchi ABSTRACT Despite the importance of Wnt signaling for adult intestinal stem cell homeostasis and colorectal cancer, relatively little is known about its role in colon formation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (7): dev173781.
Published: 6 April 2020
... Imaginal disc Intestine Regeneration In the early 1900s, Thomas Hunt Morgan turned his research focus to examine the genetic basis of heredity in the organism Drosophila , moving away from previous efforts that included studying the biology of regeneration in the flatworm Planaria . Over 100...
Journal Articles
Journal: Development
Development (2019) 146 (11): dev174508.
Published: 5 June 2019
...Aurélien Bidaud-Meynard; Ophélie Nicolle; Markus Heck; Yann Le Cunff; Grégoire Michaux ABSTRACT Intestine function relies on the strong polarity of intestinal epithelial cells and the array of microvilli forming a brush border at their luminal pole. Combining a genetic RNA interference (RNAi...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (5): dev172189.
Published: 1 March 2019
...Namit Kumar; Yu-Hwai Tsai; Lei Chen; Anbo Zhou; Kushal K. Banerjee; Madhurima Saxena; Sha Huang; Natalie H. Toke; Jinchuan Xing; Ramesh A. Shivdasani; Jason R. Spence; Michael P. Verzi ABSTRACT Lineage-restricted transcription factors, such as the intestine-specifying factor CDX2, often have dual...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (2): dev167643.
Published: 29 January 2019
... that it also regulates critical homeostatic processes in germline and somatic stem cells, as well as regenerative processes in several tissues, including the gonad, intestine and appendages. Here, we provide an overview of JAK/STAT signaling in stem cells and regeneration, focusing on Drosophila...
Journal Articles
Journal: Development
Development (2018) 145 (15): dev165399.
Published: 1 August 2018
... mechanisms of cell fate regulation through niche-derived cues, with a particular focus on epithelial stem cells of the mammalian skin, intestine and lung. We discuss a spectrum of niche-derived biochemical, mechanical and architectural inputs that define stem cell states during morphogenesis, homeostasis...
Journal Articles
Journal: Development
Development (2017) 144 (21): 3990–4001.
Published: 1 November 2017
... by activating Robo signaling in stem cells. Importantly, loss of Atg16 or decreased Slit/Robo signaling triggers an intestinal inflammatory response. Surprisingly, analysis of Rab19 and domain-specific Atg16 mutants indicates that their stem cell niche regulatory function is independent of autophagy. Our study...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (15): 2764–2770.
Published: 1 August 2017
... it remains controversial whether AChE functions in this capacity in vivo . Here, we show that AChE plays an essential non-classical role in vertebrate gut morphogenesis. Exposure of Xenopus embryos to AChE-inhibiting chemicals results in severe defects in intestinal development. Tissue-targeted loss...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (6): 1045–1055.
Published: 15 March 2017
...Yu-Hwai Tsai; Roy Nattiv; Priya H. Dedhia; Melinda S. Nagy; Alana M. Chin; Matthew Thomson; Ophir D. Klein; Jason R. Spence ABSTRACT The intestine plays a central role in digestion, nutrient absorption and metabolism, with individual regions of the intestine having distinct functional roles. Many...
Includes: Supplementary data