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Keywords: Intestinal stem cell
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Journal Articles
Journal: Development
Development (2022) 149 (1): dev199587.
Published: 12 January 2022
... that colonic recovery from colitis-like injury depends on multiple Wnt-producing sources. Wntless Wnt Tagln Acta2 Gpr177 Colitis Wound healing Intestinal stem cell National Institutes of Health R01DK102934 R01DE026936 R01DE015654 R01DK119198 R01AT010243 American Cancer...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (1): dev196568.
Published: 7 January 2021
... , A. , Al Zouabi , L. , Schweisguth , F. and Bardin , A. J. ( 2018 ). Spen limits intestinal stem cell self-renewal . PLoS Genet. 14 , e1007773 . 10.1371/journal.pgen.1007773 Antonello , Z. A. , Reiff , T. , Ballesta-Illan , E. and Dominguez , M. ( 2015...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (17): dev185678.
Published: 2 September 2020
...Gaigai Wei; Na Gao; Jiwei Chen; Lingling Fan; Zhiyang Zeng; Ganglong Gao; Liang Li; Guojiu Fang; Kewen Hu; Xiufeng Pang; Heng-Yu Fan; Hans Clevers; Mingyao Liu; Xueli Zhang; Dali Li ABSTRACT Homeostasis of intestinal stem cells (ISCs) is maintained by the orchestration of niche factors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (15): dev182675.
Published: 3 August 2020
...Anna Baulies; Nikolaos Angelis; Vivian S. W. Li ABSTRACT Intestinal stem cells (ISCs) are highly proliferative cells that fuel the continuous renewal of the intestinal epithelium. Understanding their regulatory mechanisms during tissue homeostasis is key to delineating their roles in development...
Journal Articles
Journal: Development
Development (2020) 147 (1): dev181966.
Published: 3 January 2020
...Jesse R. Raab; Deepthi Y. Tulasi; Kortney E. Wager; Jeremy M. Morowitz; Scott T. Magness; Adam D. Gracz ABSTRACT Intestinal stem cell (ISC) plasticity is thought to be regulated by broadly permissive chromatin shared between ISCs and their progeny. Here, we have used a Sox9 EGFP reporter to examine...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (22): 4091–4102.
Published: 15 November 2017
... organ-boundary intestinal stem cells (OB-ISCs) is regulated by the neighboring hindgut, a developmentally distinct organ. This distinct OB-ISC control occurs through proximity to a specialized transition zone between the endodermal midgut and ectodermal hindgut that shares molecular signatures of both...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (20): 3478–3487.
Published: 15 October 2015
... enriched in adult intestinal stem cells in the Drosophila intestine. lin-28 null mutants are homozygous viable but display defects in this population of cells, which fail to undergo a characteristic food-triggered expansion in number and have reduced rates of symmetric division as well as reduced insulin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (19): 3321–3331.
Published: 1 October 2015
...Chenhui Wang; Xingting Guo; Kun Dou; Hongyan Chen; Rongwen Xi In adult Drosophila midgut, intestinal stem cells (ISCs) periodically produce progenitor cells that undergo a binary fate choice determined primarily by the levels of Notch activity that they receive, before terminally differentiating...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (12): 2147–2162.
Published: 15 June 2015
... provided an opportunity to examine the intestinal stem cell response to a perturbed niche Wnt signal. First, Rab8a deficiency reduced Wnt secretion by ∼80%. Cells might respond to this by increasing their sensitivity to the ligand. This was indeed observed in Rab8a −/− MEFs. Second, LRC secretory...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (4): 644–653.
Published: 15 February 2015
...Xiankun Zeng; Steven X. Hou Functional mature cells are continually replenished by stem cells to maintain tissue homoeostasis. In the adult Drosophila posterior midgut, both terminally differentiated enterocyte (EC) and enteroendocrine (EE) cells are generated from an intestinal stem cell (ISC...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (23): 4647–4656.
Published: 1 December 2013
.... Published by The Company of Biologists Ltd 2013 Drosophila Insulin Dilp Germline stem cell Intestinal stem cell Hematopoietic progenitor cell Neural stem cell Amino acid sensing Nutritional control Stem cells possess the ability to self-renew and also to give rise...
Journal Articles
Journal: Development
Development (2013) 140 (1): 66–75.
Published: 1 January 2013
... Wnt signalling Notch signalling Intestinal stem cell Mouse The intestinal epithelium is characterised by rapid and continuous renewal throughout life. One of the major players involved in the renewal of the intestinal epithelium is the canonical Wnt signalling pathway. Experimental...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (24): 4135–4145.
Published: 15 December 2010
... 2010. Hippo pathway Intestinal stem cell Regeneration Drosophila SCs underlie the turnover of differentiated cells in many adult tissues ( Blanpain and Fuchs, 2009 ; Reya et al., 2001 ). In the absence of damage, the baseline level at which SCs replace differentiated cells...
Includes: Supplementary data