... that colonic recovery from colitis-like injury depends on multiple Wnt-producing sources. Wntless Wnt Tagln Acta2 Gpr177 Colitis Wound healing Intestinal stem cell National Institutes of Health R01DK102934 R01DE026936 R01DE015654 R01DK119198 R01AT010243 American Cancer...

... labeled in the intestines of I-KCKT strains. Fig. 1. KD driver analysis identifies a pan-intestinal enhancer in adults. (A) Schematic of the intestinal stem cell lineage, which includes intestinal stem cells (ISCs) and enteroblasts (EBs), collectively referred to as progenitor cells, as well...

...Gaigai Wei; Na Gao; Jiwei Chen; Lingling Fan; Zhiyang Zeng; Ganglong Gao; Liang Li; Guojiu Fang; Kewen Hu; Xiufeng Pang; Heng-Yu Fan; Hans Clevers; Mingyao Liu; Xueli Zhang; Dali Li ABSTRACT Homeostasis of intestinal stem cells (ISCs) is maintained by the orchestration of niche factors...

...Anna Baulies; Nikolaos Angelis; Vivian S. W. Li ABSTRACT Intestinal stem cells (ISCs) are highly proliferative cells that fuel the continuous renewal of the intestinal epithelium. Understanding their regulatory mechanisms during tissue homeostasis is key to delineating their roles in development...

...Jesse R. Raab; Deepthi Y. Tulasi; Kortney E. Wager; Jeremy M. Morowitz; Scott T. Magness; Adam D. Gracz ABSTRACT Intestinal stem cell (ISC) plasticity is thought to be regulated by broadly permissive chromatin shared between ISCs and their progeny. Here, we have used a Sox9 EGFP reporter to examine...

... organ-boundary intestinal stem cells (OB-ISCs) is regulated by the neighboring hindgut, a developmentally distinct organ. This distinct OB-ISC control occurs through proximity to a specialized transition zone between the endodermal midgut and ectodermal hindgut that shares molecular signatures of both...

... enriched in adult intestinal stem cells in the Drosophila intestine. lin-28 null mutants are homozygous viable but display defects in this population of cells, which fail to undergo a characteristic food-triggered expansion in number and have reduced rates of symmetric division as well as reduced insulin...

...Chenhui Wang; Xingting Guo; Kun Dou; Hongyan Chen; Rongwen Xi In adult Drosophila midgut, intestinal stem cells (ISCs) periodically produce progenitor cells that undergo a binary fate choice determined primarily by the levels of Notch activity that they receive, before terminally differentiating...

... maturation. Rab8a Gpr177 Wntless Wnt secretion Intestinal stem cell Paneth cell Wnts are cysteine-rich glycolipoproteins that act as paracrine or autocrine ligands believed to engage in short-range signaling ( Willert et al., 2003 ; Willert and Nusse, 2012 ). Signal transduction...

...Xiankun Zeng; Steven X. Hou Functional mature cells are continually replenished by stem cells to maintain tissue homoeostasis. In the adult Drosophila posterior midgut, both terminally differentiated enterocyte (EC) and enteroendocrine (EE) cells are generated from an intestinal stem cell (ISC...

.... , Ip Y. T. ( 2009 ). Tissue damage-induced intestinal stem cell division in Drosophila . Cell Stem Cell 4 , 49 – 61 . Artavanis-Tsakonas S. , Muskavitch M. A. ( 2010 ). Notch: the past, the present, and the future . Curr. Top. Dev. Biol. 92 , 1 – 29 . Artavanis...

... 2012 © 2013. Published by The Company of Biologists Ltd Wnt signalling Notch signalling Intestinal stem cell Mouse The intestinal epithelium is characterised by rapid and continuous renewal throughout life. One of the major players involved in the renewal of the intestinal...

... this switch are poorly understood. Hippo pathway Intestinal stem cell Regeneration Drosophila © 2010. 2 11 2010 Competing interests statement * Authors for correspondence ( perrimon@receptor.med.harvard.edu ; pkarpowicz@genetics.med.harvard.edu...