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Keywords: Intestinal stem cell
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Journal Articles
Journal: Development
Development (2024) 151 (1): dev201772.
Published: 2 January 2024
.... A similar phenomenon is found in intestinal stem cells (ISCs), except that HSD disrupts ISC maintenance and differentiation. Interestingly, tumor-like GSCs and ISCs are less responsive to HSD, which may be because of their dependence on glycolytic metabolism and high energy demand, respectively. This study...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (24): dev201958.
Published: 21 December 2023
... diseases. However, how endogenous factors influence the proliferation and differentiation of intestinal stem cells (ISCs) under physiological and pathological conditions remains poorly understood. Here, we find that the evolutionarily conserved endoplasmic reticulum membrane protein complex (EMC...
Includes: Supplementary data
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Journal Articles
Journal: Development
Development (2021) 148 (1): dev196568.
Published: 7 January 2021
... labeled in the intestines of I-KCKT strains. Fig. 1. KD driver analysis identifies a pan-intestinal enhancer in adults. (A) Schematic of the intestinal stem cell lineage, which includes intestinal stem cells (ISCs) and enteroblasts (EBs), collectively referred to as progenitor cells, as well...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (17): dev185678.
Published: 2 September 2020
...Gaigai Wei; Na Gao; Jiwei Chen; Lingling Fan; Zhiyang Zeng; Ganglong Gao; Liang Li; Guojiu Fang; Kewen Hu; Xiufeng Pang; Heng-Yu Fan; Hans Clevers; Mingyao Liu; Xueli Zhang; Dali Li ABSTRACT Homeostasis of intestinal stem cells (ISCs) is maintained by the orchestration of niche factors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (15): dev182675.
Published: 3 August 2020
...Anna Baulies; Nikolaos Angelis; Vivian S. W. Li ABSTRACT Intestinal stem cells (ISCs) are highly proliferative cells that fuel the continuous renewal of the intestinal epithelium. Understanding their regulatory mechanisms during tissue homeostasis is key to delineating their roles in development...
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Journal Articles
Journal Articles
Journal: Development
Development (2015) 142 (20): 3478–3487.
Published: 15 October 2015
... enriched in adult intestinal stem cells in the Drosophila intestine. lin-28 null mutants are homozygous viable but display defects in this population of cells, which fail to undergo a characteristic food-triggered expansion in number and have reduced rates of symmetric division as well as reduced insulin...
Includes: Supplementary data
Journal Articles
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Journal Articles
Journal: Development
Development (2015) 142 (4): 644–653.
Published: 15 February 2015
...Xiankun Zeng; Steven X. Hou Functional mature cells are continually replenished by stem cells to maintain tissue homoeostasis. In the adult Drosophila posterior midgut, both terminally differentiated enterocyte (EC) and enteroendocrine (EE) cells are generated from an intestinal stem cell (ISC...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (23): 4647–4656.
Published: 1 December 2013
.... , Ip Y. T. ( 2009 ). Tissue damage-induced intestinal stem cell division in Drosophila . Cell Stem Cell 4 , 49 – 61 . Artavanis-Tsakonas S. , Muskavitch M. A. ( 2010 ). Notch: the past, the present, and the future . Curr. Top. Dev. Biol. 92 , 1 – 29 . Artavanis...
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Journal Articles