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Keywords: Integrins
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Journal Articles
Journal: Development
Development (2021) 148 (5): dev186106.
Published: 9 March 2021
... and subcellular distribution of progenitor cell integrins, supporting symmetric divisions that expand intestinal stem cell populations. Collectively, our data emphasize the impact of commensal microbes on division and maintenance of the intestinal progenitor compartment. * These authors contributed equally...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (14): dev184234.
Published: 17 July 2020
... migration, cells undergo cycles of coordinated attachment and detachment from the extracellular matrix (ECM). Embryonic migration processes that require cell-ECM attachment are dependent on the integrin family of adhesion receptors. Precise regulation of integrin-mediated adhesion is important for many...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2019) 146 (23): dev182774.
Published: 9 December 2019
...Holly E. Lovegrove; Dan T. Bergstralh; Daniel St Johnston ABSTRACT The Drosophila egg chamber comprises a germline cyst surrounded by a tightly organised epithelial monolayer, the follicular epithelium (FE) . Loss of integrin function from the FE disrupts epithelial organisation at egg chamber...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (5): 795–807.
Published: 1 March 2017
... and the restriction of these processes once regeneration is complete. In planarians, flatworms with high regenerative potential, muscle cells express some of these instructive cues. Here, we show that members of the integrin family of adhesion molecules are required for the integrity of regenerating tissues...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (4): 795–806.
Published: 15 February 2014
... integrin α v β 3 on basal progenitors in embryonic mouse neocortex promotes their expansion. Specifically, integrin α v β 3 activation causes an increased cell cycle re-entry of Pax6-negative, Tbr2-positive intermediate progenitors, rather than basal radial glia, and a decrease in the proportion...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (9): 2050–2060.
Published: 1 May 2013
... astrocyte differentiation. The addition of exogenous laminins to laminin-null retinal explants rescues astrocyte migration and spatial patterning. Furthermore, we show that the loss of laminins reduces β1 integrin expression in astrocytes. Culturing laminin-null retinal astrocytes on laminin substrates...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (18): 4025–4037.
Published: 15 September 2011
... by laminin 211, or glycosylated by Large and fukutin during sorting. Candidates are αβ1 integrins, because their absence phenocopies laminin and glycosyltransferase deficiency, but the topography of the phenotypes is different and β1 integrins are not substrates for Large and fukutin. By contrast, deletion...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (17): 3813–3822.
Published: 1 September 2011
... and pathogenic damage and from changes in the ionic environment. Integrins, a major family of ECM receptors, play a number of roles in the development of myelinating Schwann cells, one class of glia ensheathing the peripheral nerves of vertebrates. However, the identity and the role of the integrin complexes...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (5): 843–853.
Published: 1 March 2009
...Yingjie Liu; Nibedita Chattopadhyay; Shan Qin; Charles Szekeres; Tetyana Vasylyeva; Zhen X. Mahoney; Mary Taglienti; Carlton M. Bates; Harold A. Chapman; Jeffrey H. Miner; Jordan A. Kreidberg Integrin receptors for the extracellular matrix and receptor tyrosine kinase growth factor receptors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (24): 4469–4478.
Published: 15 December 2007
... to interact not only with Grip but also with multiple edematous wings , which encodes one subunit of the αPS1-βPS integrin expressed in tendon cells. These experiments uncovered a previously unrecognized role for the αPS1-βPS integrin in the formation of muscle projections during early stages of myotendinous...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (17): 3155–3165.
Published: 1 September 2007
..., ectoderm is the major producer of fibronectin ( Fn1 ) transcripts, whereas all but the anterior-most region of the PSM expresses the fibronectin assembly receptor, integrinα5 ( Itga5 ). We thus propose that the ectoderm-derived fibronectin is assembled by mesodermal α5β1 integrin on the surface of the PSM...
Journal Articles
Journal: Development
Development (2004) 131 (23): 5795–5805.
Published: 1 December 2004
...Caroline Grabbe; Christos G. Zervas; Tony Hunter; Nicholas H. Brown; Ruth H. Palmer The mammalian focal adhesion kinase (FAK) family of non-receptor protein-tyrosine kinases has been implicated in controlling a multitude of cellular responses to the engagement of cell-surface integrins and G...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (12): 2611–2621.
Published: 15 June 2003
...Kathleen A. Clark; Maura McGrail; Mary C. Beckerle Integrins play a crucial role in cell motility, cell proliferation and cell survival. The evolutionarily conserved LIM protein PINCH is postulated to act as part of an integrin-dependent signaling complex. In order to evaluate the role of PINCH...
Journal Articles
Journal: Development
Development (2003) 130 (2): 355–367.
Published: 15 January 2003
... of vascular defects around E11.5 due to haemorrhage and vascular integrity defects. Vascular supporting cells did not develop appropriately. C3G-deficient fibroblasts responded to PDGF-BB abnormally, exhibited cell adhesion defects and lacked paxillin and integrin-β1-positive cell adhesions. In contrast...
Journal Articles
Journal: Development
Development (1993) 119 (Supplement): 177–183.
Published: 1 December 1993
...Nicholas H. Brown; James W. Bloor; Olga Dunin-Borkowski; M. Dolores Martín-Bermudo The Drosophila position specific (PS) integrins consist of two cell surface heterodimers, PSl (α Ps1 β PS ) and PS2 (α Ps2 β PS ), which are expressed on complementary sides of attachments between cell layers...
Journal Articles
Journal: Development
Development (1993) 117 (4): 1183–1198.
Published: 1 April 1993
...Josephine C. Adams; Fiona M. Watt *Author for correspondence © 1993 by Company of Biologists 1993 extracellular matrix integrins proteoglycans signal transduction growth factors differentiation REFERENCES Adams J. C. , Watt F. M. ( 1989 ) Fibronectin...
Journal Articles
Journal: Development
Development (1992) 116 (Supplement): 127–136.
Published: 1 April 1992
... of gastrulation? What is the molecular basis of gastrulation? Copyright © 1992 by Company of Biologists 1992 Xenopus gastrulation mesoderm induction activin BMP-4 FGF Wnt integrins Mesoderm induction and origins of the embryonic axis Development 1992 Supplement, 127-136(1992) Printed in Great...