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Keywords: Insulin
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Journal Articles
Journal: Development
Development (2023) 150 (20): dev201599.
Published: 17 October 2023
...Miyuki Suzawa; Michelle L. Bland ABSTRACT Nutrient intake is obligatory for animal growth and development, but nutrients alone are not sufficient. Indeed, insulin and homologous hormones are required for normal growth even in the presence of nutrients. These hormones communicate nutrient status...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (1): dev201248.
Published: 6 January 2023
...Kota Banzai; Takashi Nishimura ABSTRACT Evolutionarily conserved insulin/insulin-like growth factor (IGF) signaling (IIS) correlates nutrient levels to metabolism and growth, thereby playing crucial roles in development and adult fitness. In the fruit fly Drosophila , ImpL2, an ortholog of IGFBP7...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (6): dev200491.
Published: 28 March 2022
... and whole-body glycogen and protein. In males, the low-sugar diet augmented insulin/insulin-like growth factor signalling pathway (IIS) activity by increasing insulin sensitivity, where increased IIS was required for male metabolic and body size responses in 0S. In females reared on low sugar, IIS activity...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2021) 148 (8): dev197087.
Published: 23 April 2021
.... Drosophila Growth Insulin Regeneration Signaling One of the most exciting questions in regenerative biology is how damaged cells signal to their surviving neighbors to stimulate tissue repair ( Hariharan and Serras, 2017 ). The stress-activated MAP kinases Jun N-terminal kinase (JNK) and p38...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (1): dev190868.
Published: 10 January 2021
...Myung-Jun Kim; Michael B. O'Connor ABSTRACT The Myostatin/Activin branch of the TGF-β superfamily acts as a negative regulator of vertebrate skeletal muscle size, in part, through downregulation of insulin/insulin-like growth factor 1 (IGF-1) signaling. Surprisingly, recent studies in Drosophila...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (21): dev165654.
Published: 2 November 2018
... for an orderly progression of development and growth. In Drosophila , this involves insulin and steroid signalling, but the underlying mechanisms and their coordination are incompletely understood. We show that bioactive 20-hydroxyecdysone production by the enzyme Shade in the fat body is a nutrient-dependent...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2018) 145 (6): dev158865.
Published: 14 March 2018
...-4658.2010.07811.x Nässel , D. R. and Vanden Broeck , J. ( 2016 ). Insulin/IGF signaling in Drosophila and other insects: factors that regulate production, release and post-release action of the insulin-like peptides . Cell Mol. Life Sci.   73 , 271 - 290 . 10.1007/s00018-015-2063-3...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (23): 4406–4421.
Published: 1 December 2017
... hormone 20-hydroxyecdysone (20E) in the maintenance of numerous patterning systems in vivo and in explant culture. We find that low concentrations of 20E support prolonged proliferation in explanted wing discs in the absence of insulin, incidentally providing novel insight into the hormonal regulation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (21): 3914–3925.
Published: 1 November 2016
... cyst stem cells (CySCs) in the Drosophila testis is actively promoted by PI3K/Tor signaling, as CySCs lacking PI3K/Tor activity cannot differentiate properly. We find that an insulin peptide produced by somatic cells immediately outside of the stem cell niche acts locally to promote somatic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (8): 1407–1417.
Published: 15 April 2015
... of contextual regulators of cell fate acquisition and maintenance. In murine models of diabetes, glucagon-secreting alpha cells transdifferentiate into insulin-secreting beta cells following targeted beta cell depletion, regenerating the form and function of the pancreatic islet. However, the molecular triggers...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (5): 858–870.
Published: 1 March 2015
... in humans, causes pancreatic endocrine differentiation defects leading to cyst formation. Embryo Pancreas Progenitors Endocrine Beta cell Insulin Diabetes Differentiation RNA-binding protein Cysts MODY5 The pancreas is an endoderm-derived organ with dual functions. Acini have...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (8): 1767–1779.
Published: 15 April 2014
...Wesley L. Hung; Ying Wang; Jyothsna Chitturi; Mei Zhen Adverse environmental conditions trigger C. elegans larvae to activate an alternative developmental program, termed dauer diapause, which renders them stress resistant. High-level insulin signaling prevents constitutive dauer formation. However...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (23): 4647–4656.
Published: 1 December 2013
... studies that pertain to nutritional effects on stem and progenitor cell maintenance and proliferation in Drosophila . Multiple tissue types are discussed that utilize the insulin-related signaling pathway to convey nutritional information either directly to these progenitors or via other cell types within...
Journal Articles
Journal: Development
Development (2012) 139 (10): 1713–1717.
Published: 15 May 2012
...Billel Benmimoun; Cédric Polesello; Lucas Waltzer; Marc Haenlin The interconnected Insulin/IGF signaling (IlS) and Target of Rapamycin (TOR) signaling pathways constitute the main branches of the nutrient-sensing system that couples growth to nutritional conditions in Drosophila . Here, we...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (5): 859–870.
Published: 1 March 2012
... pool more severely than either single mutant and similarly to reducing the activity of let-363 (TOR) or daf-15 (RAPTOR). Moreover, rsks-1 acts in parallel with the glp-1 (Notch) and daf-2 (insulin-IGF receptor) pathways, and does not share the same genetic dependencies with its role in lifespan control...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (14): 2883–2893.
Published: 15 July 2011
...Helen J. Hwang; Eric Rulifson We used the brain insulin-producing cell (IPC) lineage and its identified neuroblast (IPC NB) as a model to understand a novel example of serial specification of NB identities in the Drosophila dorsomedial protocerebral neuroectoderm. The IPC NB was specified from...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (13): 2693–2703.
Published: 1 July 2011
... that activin signaling regulates competence of the prothoracic gland to receive PTTH and insulin signals, and that these two pathways act at the mRNA and post-transcriptional levels, respectively, to control ecdysone biosynthetic enzyme expression. This dual regulatory circuitry may provide a cross-check...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (4): 631–640.
Published: 15 February 2011
... for correspondence ( shuolin@ucla.edu ) Competing interests statement 26 11 2010 © 2011. Zebrafish Endocrine Pancreas Bmp Hedgehog Retinoic acid Pdx1 Insulin β-cell Endoderm The pancreas develops from the endoderm germ layer, which during early...
Includes: Supplementary data