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Keywords: Insulator
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Journal Articles
Journal: Development
Development (2017) 144 (14): 2663–2672.
Published: 15 July 2017
... in PMC for release after 12 months. References Ali , T. , Renkawitz , R. and Bartkuhn , M. ( 2016 ). Insulators and domains of gene expression . Curr. Opin. Genet. Dev.   37 , 17 - 26 . 10.1016/j.gde.2015.11.009 Aoki , T. , Sarkeshik , A. , Yates , J...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (13): 2389–2397.
Published: 1 July 2016
... specification is incompletely understood. In this article, we identify the insulator protein BEAF-32 as a regulator of Hippo pathway activity in Drosophila photoreceptor differentiation. Though morphologically uniform, the fly eye is composed of two subtypes of R8 photoreceptor neurons defined by expression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (19): 3613–3622.
Published: 1 October 2012
...Mamiko Yajima; William G. Fairbrother; Gary M. Wessel Insulators are genomic elements that regulate transcriptional activity by forming chromatin boundaries. Various DNA insulators have been identified or are postulated in many organisms, and the paradigmatic CTCF-dependent insulators are perhaps...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (6): 1045–1057.
Published: 15 March 2012
...Martin Herold; Marek Bartkuhn; Rainer Renkawitz The genome of higher eukaryotes exhibits a patchwork of inactive and active genes. The nuclear protein CCCTC-binding factor (CTCF) when bound to insulator sequences can prevent undesirable crosstalk between active and inactive genomic regions...
Journal Articles
Journal: Development
Development (2009) 136 (18): 3077–3087.
Published: 15 September 2009
...Miki Fujioka; Xian Wu; James B. Jaynes Insulator sequences help to organize the genome into discrete functional regions by preventing inappropriate cross-regulation. This is thought to be mediated in part through associations with other insulators located elsewhere in the genome. Enhancers...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (24): 3983–3987.
Published: 15 December 2008
...Carole Iampietro; Fabienne Cléard; Henrik Gyurkovics; Robert K. Maeda; François Karch Although the boundary elements of the Drosophila Bithorax complex(BX-C) have properties similar to chromatin insulators, genetic substitution experiments have demonstrated that these elements do more than simply...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (15): 2983–2993.
Published: 1 August 2006
... constructs revealed the existence of several types of regulatory elements in each of the cis-regulatory regions. These include initiation elements, maintenance elements, cell type- or tissue-specific enhancers, chromatin insulators and the promoter targeting sequence. In this paper, we extend the analysis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (21): 4743–4753.
Published: 1 November 2005
... HEAT Repeat Insulator Scc3/stromalin Smc1 Spo76 Current evidence indicates that most transcriptional activator proteins recruit the basal transcriptional machinery and increase its binding to a promoter ( Ptashne and Gann,2001 ). When an activator binds DNA within a kilobase or so...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (19): 4743–4749.
Published: 1 October 2004
... (domains) of genetic regulation that boundaries delimit can expand or contract by switching insulator function off or on in a temporally regulated fashion. * Author for correspondence (e-mail: pschedl@molbio.princeton.edu ) 8 7 2004 © 2004. 2004 Fab-7 Drosophila Bithorax...
Journal Articles
Journal: Development
Development (2003) 130 (14): 3249–3258.
Published: 15 July 2003
...Anton Golovnin; Inna Biryukova; Olga Romanova; Margarita Silicheva; Akeksander Parshikov; Ekaterina Savitskaya; Vincenzo Pirrotta; Pavel Georgiev The best characterized chromatin insulator in Drosophila is the Suppressor of Hairy wing binding region contained within the gypsy retrotransposon...
Journal Articles
Journal: Development
Development (2003) 130 (3): 519–526.
Published: 1 February 2003
... complex facilitates the activity of a distantly located enhancer in transgenic embryos and that it restricts the enhancer to a single promoter. These functions are heritable in all successive generations. We also show that the PTS functions only when itself and an insulator are located between...
Journal Articles
Journal: Development
Development (2002) 129 (23): 5521–5528.
Published: 1 December 2002
... sequences located at remote distances. However, in different cellular contexts, Hox genes may have to be insulated from undesirable external regulatory influences to prevent ectopic gene activation, a situation that would likely be detrimental to the developing embryo. We show the presence of an insulator...
Journal Articles
Journal: Development
Development (2002) 129 (21): 4915–4922.
Published: 1 November 2002
...Ilham Hogga; François Karch The Fab-7 chromatin domain boundary insures functional autonomy of the iab-6 and iab-7 cis -regulatory domains in the bithorax complex (BX-C). We have previously shown that chromatin insulators such as gypsy or scs min are potent insulators that cannot substitute...
Journal Articles
Journal: Development
Development (2001) 128 (21): 4339–4347.
Published: 1 November 2001
...Haini N. Cai; Zhengang Zhang; Jessica R. Adams; Ping Shen Chromatin insulators regulate gene expression by preventing inappropriate enhancer-promoter interactions. Our previous study showed that insulators do not merely function as rigid blockers, rather their activities are quantitative...