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Keywords: Infertility
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Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2022) 149 (16): dev200499.
Published: 22 August 2022
... to result in blockage of autophagic flux, which could explain the failure in acrosome formation. In vitro fertilization demonstrated that PFN4-deficient sperm is capable of fertilizing zona-free oocytes, suggesting a potential treatment for PFN4-related human infertility. * Present address...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (12): dev200330.
Published: 20 June 2022
... by protamines. In humans and mice, protamine 1 ( PRM1 / Prm1 ) and protamine 2 ( PRM2 / Prm2 ) are expressed in a species-specific ratio. Using CRISPR-Cas9-mediated gene editing, we generated Prm1 -deficient mice and demonstrated that Prm1 +/− mice were subfertile, whereas Prm1 −/− mice were infertile. Prm1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (12): dev199573.
Published: 16 June 2022
... undergoing spermiogenesis. Poly(A) tail MicroRNA Deadenylation Adenylation RNP Polysome Spermiogenesis Alternative splicing Uncoupling of transcription and translation Infertility Mouse National Key Research and Development Program of China http://dx.doi.org/10.13039/501100012166...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (8): dev197558.
Published: 16 April 2021
....1120230205 Baccetti , B. , Collodel , G. , Estenoz , M. , Manca , D. , Moretti , E. and Piomboni , P. ( 2005 ). Gene deletions in an infertile man with sperm fibrous sheath dysplasia . Hum. Reprod. 20 , 2790 - 2794 . 10.1093/humrep/dei126 Barrera , J...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (1): dev191189.
Published: 13 January 2021
...Carolina J. Jorgez; Abhishek Seth; Nathan Wilken; Juan C. Bournat; Ching H. Chen; Dolores J. Lamb ABSTRACT Cryptorchidism is the most common urologic birth defect in men and is a predisposing factor of male infertility and testicular cancer, yet the etiology remains largely unknown. E2F1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (16): dev160614.
Published: 16 April 2018
...% of males these checkpoints cause complete meiotic arrest leading to azoospermia and subsequent infertility. Here, we unravel two clearly distinct meiotic arrest mechanisms that occur during prophase of human male meiosis. Type I arrested spermatocytes display severe asynapsis of the homologous chromosomes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (1): 151–157.
Published: 1 January 2010
... and proteins produced from seminiferous tubules. Gpr48 -null male mice demonstrate reproductive tract defects and infertility. In the present study, we found that estrogen receptor α (ERα) was dramatically reduced in the epididymis and efferent ducts in Gpr48 -null male mice. We further revealed that ERα could...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (9): 2183–2194.
Published: 1 May 2004
... a Drosophila homolog of human PARK2 and characterized its expression and null phenotype. parkin null flies have 30% lower mass than wild-type controls which is in part accounted for by a reduced cell size and number. In addition, these flies are infertile, show significantly reduced longevity, and are unable...
Journal Articles
Journal: Development
Development (2003) 130 (10): 2253–2261.
Published: 15 May 2003
... Tnfip6 Tsg6 Inter-α-trypsin inhibitor Hyaluronan Extracellular matrix Infertility Mammalian ovulation involves a variety of coordinated physiological and biochemical processes that eventually culminate in the expulsion of the cumulus cell-oocyte complex (COC) from the preovulatory follicle...