... output to a narrow distal regenerate zone comprising pObs and adjacent motile basal epidermal cells. This Hh/Smo activity is driven by epidermal Sonic hedgehog a (Shha) rather than Ob-derived Indian hedgehog a (Ihha), which nevertheless functions atypically to support bone maturation. Using BMS-833923...

....90.15.7230 Lozito , T. P. and Tuan , R. S. ( 2015 ). Lizard tail regeneration: regulation of two distinct cartilage regions by Indian hedgehog . Dev. Biol.   399 , 249 - 262 . 10.1016/j.ydbio.2014.12.036 Morrison , J. I. , Lööf , S. , He , P. P. and Simon...

... signaling stimulates the expression and activity of Indian hedgehog, increases the expression of β-catenin and inhibits Notch2. Our findings identify Vegfa as a regulator of perichondrial vascularity and osteoblast differentiation at early stages of bone development. In rescue experiments, Osx...

.... and O'Keefe , R. J. ( 2001 ). BMP signaling stimulates chondrocyte maturation and the expression of Indian hedgehog . J. Orthop. Res. 19 , 18 - 25 . 10.1016/S0736-0266(00)00017-6 Hilton , M. J. , Tu , X. and Long , F. ( 2007 ). Tamoxifen-inducible gene deletion reveals...

...Shu-Hsuan C. Hsu; Xiaoyun Zhang; Chunying Yu; Zhu Juan Li; Jay S. Wunder; Chi-Chung Hui; Benjamin A. Alman Proper regulation of Indian hedgehog (Ihh) signaling is vital for chondrocyte proliferation and differentiation in the growth plate. Its dysregulation causes skeletal dysplasia, osteoarthritis...

... by antagonistic BMP and FGF signaling pathways. © 2006. 2006 Bone morphogenetic protein Cartilage Chondrogenesis Fibroblast growth factor indian hedgehog BMP receptors Mouse Endochondral ossification is the multistep process that forms the majority of the skeletal system. This process...

... column-forming proliferating cells (columnar chondrocytes), stop dividing and finally differentiate into hypertrophic cells. Indian hedgehog (Ihh), which is predominantly expressed in prehypertrophic cells, stimulates expression of parathyroid hormone (PTH)-related peptide (PTHrP) which negatively...

... from extra-embryonic mesodermal cells that underlie the visceral endoderm. Our previous studies have shown that Indian hedgehog ( Ihh ) is expressed in the visceral endoderm both in the visceral yolk sac in vivo and in embryonic stem (ES) cell-derived embryoid bodies. Differentiating embryoid bodies...

... of wild-type cartilage during development, chondrocytes in A-CREB mutant cartilage exhibited a profound decrease in proliferative index and a delay in hypertrophy. Correspondingly, the expression of certain signaling molecules in cartilage, most notably the Indian hedgehog (Ihh) receptor patched (Ptch...

... a critical role in coordinating patterning and organogenesis of the gut and its derivatives. We have assessed the function of Sonic hedgehog and Indian hedgehog genes, which encode members of the Hedgehog family of cell signals. Both are expressed in gut endoderm, whereas target genes are expressed...

..., Doublefoot ( Dbf ). Dbf is a dominant mutation which maps to chromosome 1. Heterozygous and homozygous embryos display a severe polydactyly with 6 to 8 digits on each limb. We show here that Shh is expressed normally in Dbf mutants. In contrast, a second Hh family member, Indian hedgehog ( Ihh ) which maps...

... intense radial growth of the differentiating cartilages and disturb the formation of joints accompanied by alterations in the pattern of Indian hedgehog and ck-erg expression. Interestingly, the effects of these two BMPs on joint formation were found to be different. While the pre-dominant effect of BMP-2...

.... Two vertebrate hedgehog proteins, Sonic hedgehog and Indian hedgehog, have been implicated in skeletal development. During somite differentiation and limb development, Sonic hedgehog functions as an inductive signal from the notochord, floor plate and zone of polarizing activity. Later...