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Keywords: IZUMO1
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Journal Articles
Journal: Development
Development (2014) 141 (19): 3732–3739.
Published: 1 October 2014
... fusion during mammalian fertilization. After initial contact, adhesion between gametes only leads to fusion in the presence of three membrane proteins that are necessary, but insufficient, for fusion: Izumo1 on sperm, its receptor Juno on egg and Cd9 on egg. What happens during this adhesion phase...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (22): 4471–4479.
Published: 15 November 2013
... for correspondence ( okabe@biken.osaka-u.ac.jp ) Competing interests The author declares no competing financial interests. © 2013. Published by The Company of Biologists Ltd 2013 Fertilization Izumo1 Acrosome reaction Eggs Hyperactivation Spermatozoa Our individual body has...
Journal Articles
Journal: Development
Development (2013) 140 (15): 3221–3229.
Published: 1 August 2013
... unknown. Gene disruption studies have showed that IZUMO1 on spermatozoon and CD9 on oocyte are essential transmembrane proteins in sperm-egg fusion. In this study, we dissected IZUMO1 protein to determine the domains that were required for the function of sperm-egg fusion. We found that a fragment...
Includes: Supplementary data