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Keywords: Hypothalamus
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Journal Articles
In collection:
Neural development
Journal: Development
Development (2022) 149 (7): dev199966.
Published: 7 April 2022
... or morphotype-specific pattern variations are apparent. Eye-field transcription factors Telencephalon Hypothalamus Cell identity Astyanax mexicanus Natural variation Centre national de la recherche scientifique http://dx.doi.org/10.13039/501100004794 Fondation pour la...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (13): dev180950.
Published: 13 July 2020
...Timothy Goodman; Stuart G. Nayar; Shaun Clare; Marta Mikolajczak; Ritva Rice; Suzanne Mansour; Saverio Bellusci; Mohammad K. Hajihosseini ABSTRACT New neurons are generated in the postnatal rodent hypothalamus, with a subset of tanycytes in the third ventricular (3V) wall serving as neural stem...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (23): dev177790.
Published: 2 December 2019
... hypothalamus . Endocrinology   150 , 5509 - 5519 . 10.1210/en.2009-0584 El-Brolosy , M. A. , Kontarakis , Z. , Rossi , A. , Kuenne , C. , Günther , S. , Fukuda , N. , Kikhi , K. , Boezio , G. L. M. , Takacs , C. M. , Lai , S.-L. , et al. ( 2019 ). Genetic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (18): 3278–3288.
Published: 15 September 2017
...Travis Fu; Matthew Towers; Marysia A. Placzek Classical descriptions of the hypothalamus divide it into three rostro-caudal domains but little is known about their embryonic origins. To investigate this, we performed targeted fate-mapping, molecular characterisation and cell cycle analyses...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2017) 144 (9): 1588–1599.
Published: 1 May 2017
...Yuanyuan Xie; Richard I. Dorsky The hypothalamus, which regulates fundamental aspects of physiological homeostasis and behavior, is a brain region that exhibits highly conserved anatomy across vertebrate species. Its development involves conserved basic mechanisms of induction and patterning...
Journal Articles
In collection:
Neural development
Journal: Development
Development (2016) 143 (20): 3763–3773.
Published: 15 October 2016
... that the LIM-homeodomain transcription factor Isl1 is expressed in several subpopulations of developing arcuate neurons and plays crucial roles in their fate specification. Mice with conditional deletion of the Isl1 gene in developing hypothalamus display severe deficits in both feeding and linear growth...
Journal Articles
Journal: Development
Development (2016) 143 (1): 45–53.
Published: 1 January 2016
...Robert N. Duncan; Yuanyuan Xie; Adam D. McPherson; Andrew V. Taibi; Joshua L. Bonkowsky; Adam D. Douglass; Richard I. Dorsky The vertebrate hypothalamus contains persistent radial glia that have been proposed to function as neural progenitors. In zebrafish, a high level of postembryonic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (4): 633–643.
Published: 15 February 2015
..., human pluripotent stem cells are differentiated into hypothalamic neurons that regulate sleep, feeding behavior and metabolism. Differentiation Hypothalamus Narcolepsy Neuropeptide Pluripotent Stem cell Mouse Human Although it makes up only 0.3% of the adult human brain...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (17): 3511–3521.
Published: 1 September 2013
... NPY Hypothalamus Mouse The mammalian hypothalamus regulates essential and dynamic physiological functions, including growth, metabolism, sleep, as well as reproductive behaviors ( Krononberg et al., 2007 ; Caqueret et al., 2005 ; Michaud, 2001 ). The hypothalamus comprises of complex...
Journal Articles
Journal: Development
Development (2013) 140 (8): 1762–1773.
Published: 15 April 2013
...Andrea Wolf; Soojin Ryu The hypothalamus is a key integrative center in the brain that consists of diverse cell types required for a variety of functions including homeostasis, reproduction, stress response, social and cognitive behavior. Despite our knowledge of several transcription factors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (5): 1111–1122.
Published: 1 March 2013
... to potential guidance cues from the prosp-NH at E4-E5, project to dorsal regions of the NH by E6, but extend into the ventral NH only at E10. To investigate whether the ventral hypothalamus exerts a long-range guidance effect on H-NH axons, chick lateral [L] hypothalamic explants containing nascent H-NH...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (1): 151–164.
Published: 1 January 2012
.... , Ristoratore F. , Chourrout D. , Joly J. S. ( 1999 ). Expression of the medaka (Oryzias latipes) Ol-Rx3 paired-like gene in two diencephalic derivatives, the eye and the hypothalamus . Mech. Dev. 83 , 179 – 182 . Eisen J. S. , Smith J. C. ( 2008 ). Controlling morpholino...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (12): 2613–2624.
Published: 15 June 2011
... ventral midline fp cells ( Hynes et al., 1995 ; Andersson et al., 2006 ; Ono et al., 2007 ), and that, in addition to their role in infundibular formation, collar cells might contribute to, and shape, neuronal components of the hypothalamus. In summary, our data suggest the presence of a spatially...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (6): 1007–1017.
Published: 15 March 2009
... of specific dopaminergic neuron groups in the hypothalamus and posterior tuberculum. Knockdown of sim1 causes a dopaminergic phenotype similar to arnt2 mutants, suggesting that Sim1 acts as a binding partner of Arnt2, similar to their role in hypothalamic neuroendocrine cell specification. sim1, arnt2 and otp...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (20): 3325–3331.
Published: 15 October 2008
...Kyoji Ohyama; Raman Das; Marysia Placzek In the developing chick hypothalamus, Shh and BMPs are expressed in a spatially overlapping, but temporally consecutive, manner. Here, we demonstrate how the temporal integration of Shh and BMP signalling leads to the late acquisition of Pax7 expression...
Journal Articles
Journal: Development
Development (2007) 134 (5): 845–855.
Published: 1 March 2007
... not affect global forebrain regional patterning, but has several important consequences on specific regions and neuronal populations. First, we show expanded Nkx2.1a expression and higher levels of cell proliferation in the cavefish basal diencephalon and hypothalamus. Second, we uncover an Nkx2.1b-Lhx6...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (22): 4451–4461.
Published: 15 November 2006
...Ji Eun Lee; Shan-Fu Wu; Lisa M. Goering; Richard I. Dorsky Although the functional importance of the hypothalamus has been demonstrated throughout vertebrates, the mechanisms controlling neurogenesis in this forebrain structure are poorly understood. We report that canonical Wnt signaling acts...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (24): 5527–5537.
Published: 15 December 2005
... of the hypothalamus, are composed of the lateral and medial mammillary nuclei. The MBs participate in two pathways that are essential for processing spatial information (reviewed by Vann and Aggleton, 2004 ). First, the MBs link two brain regions that are crucial for episodic spatial memory, the hippocampus...
Journal Articles
Journal: Development
Development (2005) 132 (23): 5185–5197.
Published: 1 December 2005
... and m.placzek@sheffield.ac.uk ) 19 9 2005 ©2005. 2005 Shh Bmp7 Chick Dopamine Hypothalamus During development of the central nervous system (CNS), neurons are generated under the influence of secreted inductive signals( Liu and Joyner, 2001 ; Jessell, 2002 ). Signals derive from...
Journal Articles
Journal: Development
Development (2004) 131 (23): 5923–5933.
Published: 1 December 2004
.... These results suggest that Nodal signalling promotes the ability of cells to incorporate into ventral midline tissue, and within this tissue, antagonism of Wnt signalling promotes the acquisition of hypothalamic identity. Wnt signalling also affects patterning within the hypothalamus, suggesting...