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Keywords: Hyaluronan
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Journal Articles
Journal: Development
Development (2021) 148 (3): dev194563.
Published: 3 February 2021
..., macrophage hyaluronan was required for lymphatic sprouting by mediating direct macrophage-lymphatic endothelial cell interactions. Together, these findings reveal insight into the role of macrophages as indispensable mediators of lymphatic growth during the development of the mammalian cardiac vasculature...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (17): 2987–2996.
Published: 1 September 2009
... tissue injury and repair, no functional studies to evaluate its role in appendage regeneration have been performed. Studying the role of Hyaluronan(HA), an ECM component, is particularly attractive because it can activate intracellular signaling cascades after tissue injury. Here we studied the function...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (16): 2825–2835.
Published: 15 August 2009
...Kazu Matsumoto; Yingcui Li; Caroline Jakuba; Yoshinori Sugiyama; Tetsuya Sayo; Misako Okuno; Caroline N. Dealy; Bryan P. Toole; Junji Takeda; Yu Yamaguchi; Robert A. Kosher The glycosaminoglycan hyaluronan (HA) is a structural component of extracellular matrices and also interacts with cell surface...
Journal Articles
Journal: Development
Development (2006) 133 (4): 631–640.
Published: 15 February 2006
...Michela Ori; Martina Nardini; Paola Casini; Roberto Perris; Irma Nardi In vertebrates, hyaluronan biosynthesis is regulated by three transmembrane catalytic enzymes denoted Has1, Has2 and Has3. We have previously cloned the Xenopus orthologues of the corresponding genes and defined...
Journal Articles
Journal: Development
Development (2004) 131 (3): 525–537.
Published: 1 February 2004
...Jeroen Bakkers; Carina Kramer; Joris Pothof; Nicolette E. M. Quaedvlieg; Herman P. Spaink; Matthias Hammerschmidt The large extracellular polysaccharide Hyaluronan (HA) and its synthesizing enzymes (Has) have been implicated in regulating the migratory potential of metastatic cancer cells. Here, we...
Journal Articles
Journal: Development
Development (2003) 130 (10): 2253–2261.
Published: 15 May 2003
... because of the inability of the cumulus cells to assemble their hyaluronan-rich extracellular matrix. The impaired cumulus matrix formation is due to the lack of covalent complexes between hyaluronan and the heavy chains of the inter-α-trypsin inhibitor family. As a consequence, TNFIP6-deficient females...
Journal Articles
Journal: Development
Development (2001) 128 (15): 3029–3039.
Published: 1 August 2001
... this lamina-specific adhesion. We show that hyaluronidase treatment of hippocampal slices abolishes lamina-specific adhesion as well as layer-specific growth of entorhinal fibers to the dentate outer molecular layer in organotypic slice cultures. We conclude that hyaluronan-associated molecules play a crucial...