..., macrophage hyaluronan was required for lymphatic sprouting by mediating direct macrophage-lymphatic endothelial cell interactions. Together, these findings reveal insight into the role of macrophages as indispensable mediators of lymphatic growth during the development of the mammalian cardiac vasculature...

... tissue injury and repair, no functional studies to evaluate its role in appendage regeneration have been performed. Studying the role of Hyaluronan(HA), an ECM component, is particularly attractive because it can activate intracellular signaling cascades after tissue injury. Here we studied the function...

...Kazu Matsumoto; Yingcui Li; Caroline Jakuba; Yoshinori Sugiyama; Tetsuya Sayo; Misako Okuno; Caroline N. Dealy; Bryan P. Toole; Junji Takeda; Yu Yamaguchi; Robert A. Kosher The glycosaminoglycan hyaluronan (HA) is a structural component of extracellular matrices and also interacts with cell surface...

...Michela Ori; Martina Nardini; Paola Casini; Roberto Perris; Irma Nardi In vertebrates, hyaluronan biosynthesis is regulated by three transmembrane catalytic enzymes denoted Has1, Has2 and Has3. We have previously cloned the Xenopus orthologues of the corresponding genes and defined...

...Jeroen Bakkers; Carina Kramer; Joris Pothof; Nicolette E. M. Quaedvlieg; Herman P. Spaink; Matthias Hammerschmidt The large extracellular polysaccharide Hyaluronan (HA) and its synthesizing enzymes (Has) have been implicated in regulating the migratory potential of metastatic cancer cells. Here, we...

... because of the inability of the cumulus cells to assemble their hyaluronan-rich extracellular matrix. The impaired cumulus matrix formation is due to the lack of covalent complexes between hyaluronan and the heavy chains of the inter-α-trypsin inhibitor family. As a consequence, TNFIP6-deficient females...

... this lamina-specific adhesion. We show that hyaluronidase treatment of hippocampal slices abolishes lamina-specific adhesion as well as layer-specific growth of entorhinal fibers to the dentate outer molecular layer in organotypic slice cultures. We conclude that hyaluronan-associated molecules play a crucial...

...Peter Gakunga; Gregory Frost; Svetlana Shuster; Gerald Cunha; Bent Formby; Robert Stern ABSTRACT Hyaluronan, a macromolecular carbohydrate polymer of the extracellular matrix is prominent early in embryogenesis, coinciding with rapid tissue growth. CD44, the pre-dominant receptor for hyaluronan...

...I. Ellis; J. Banyard; S. L. Schor ABSTRACT Previous studies have indicated that fetal skin fibroblasts display an elevated level of migratory activity compared to adult cells and that this may result from inherent differences in the production of hyaluronan (HA) by these cells. Data presented...

...Susan C. Wheatley; Clare M. Isacke; Philip H. Crossley ABSTRACT CD44 is a multifunctional adhesion protein that acts as a major receptor for the hygroscopic extracellular matrix component, hyaluronan. This receptor-ligand binding directly mediates at least some of the cell-cell and cell-matrix...

...Jeremy J. G. Brown; Virginia E. Papaioannou ABSTRACT The ontogeny of hyaluronan (HA) secretion during early mouse embryogenesis has been investigated using a biotin-labelled HA-binding complex from cartilage proteoglycan. HA is first secreted by visceral endoderm cells of the early egg cylinder...

... into the core of a protrusion in vivo , the protrusion collapses and the corresponding semicircular canal fails to form. Hyaluronan (hyaluronic acid) in the core of the protrusion therefore seems to be essential in driving the extension of the protrusion. Autoradiography with tritiated glucosamine indicates...

...Roberto Perris; Danuta Krotoski; Thomas Lallier; Carmen Domingo; J. Michael Sorrell; Marianne Bronner-Fraser In this study, we describe the distribution of various classes of proteoglycans and their potential matrix ligand, hyaluronan, during neural crest development in the trunk region...