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Keywords: Human embryonic stem cells
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Journal Articles
Journal: Development
Development (2021) 148 (22): dev199378.
Published: 12 November 2021
... conservation observed. Single-cell transcriptomics analysis of human embryos previously enabled us to identify transcription factors, including the zinc-finger protein KLF17, that are enriched in the human epiblast and naïve human embryonic stem cells (hESCs). Here, we show that KLF17 is expressed coincident...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (19): dev199513.
Published: 05 October 2021
... derived from human embryonic stem cells (hESCs). Specifically, we observed a reduction in the extension of the ectodermal compartment that is associated with enhanced activin signaling. Surprisingly, rather than a cell-autonomous effect, tracking the dynamics of TGFβ signaling demonstrated that HTT-CAG...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (23): dev190298.
Published: 13 December 2020
...Siqi Yi; Xiaotian Huang; Shixin Zhou; Yuan Zhou; Michele K. Anderson; Juan Carlos Zúñiga-Pflücker; Qingxian Luan; Yang Li ABSTRACT E protein transcription factors are crucial for many cell fate decisions. However, the roles of E proteins in the germ-layer specification of human embryonic stem cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (20): dev179093.
Published: 17 October 2019
... 9 2019 © 2019. Published by The Company of Biologists Ltd 2019 http://www.biologists.com/user-licence-1-1/ Highlighted Article: An in vitro system based on human embryonic stem cells recapitulates the medial-lateral patterning of human ectoderm and reveals how the ectoderm...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (16): dev175604.
Published: 29 August 2019
... (anterior) or trunk (posterior) identity based on the magnitude of the WNT signal used to induce them. Neural crest WNT dose/magnitude Anterior-posterior axis HOX genes Human embryonic stem cells Neural crest cells (NCCs) are multipotent embryonic cells that are exclusive to vertebrates...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (2): dev156844.
Published: 29 January 2018
... in the Huntingtin gene ( HTT ). Neither its pathogenic mechanisms nor the normal functions of HTT are well understood. To model HD in humans, we engineered a genetic allelic series of isogenic human embryonic stem cell (hESC) lines with graded increases in CAG repeat length. Neural differentiation of these lines...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev159905.
Published: 08 January 2018
... Endothelial differentiation Human embryonic stem cells Cardiovascular progenitor Wnt signaling Non-canonical Wnt Wnt5a Mouse One out of every three deaths in the USA results from cardiovascular disease ( Roger et al., 2012 ). Despite the epidemic scale of predisposing conditions (hypertension...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (17): 3042–3053.
Published: 01 September 2017
...Anastasiia Nemashkalo; Albert Ruzo; Idse Heemskerk; Aryeh Warmflash Paracrine signals maintain developmental states and create cell fate patterns in vivo and influence differentiation outcomes in human embryonic stem cells (hESCs) in vitro . Systematic investigation of morphogen signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (6): 1025–1034.
Published: 15 March 2017
... and apoptosis, in developing and adult brain. In addition, the RB family is required for self-renewal and survival of human embryonic stem cells (hESCs). Since little is known about the role of RB in human brain development, we investigated its function in cerebral organoids differentiated from gene-edited...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (19): 3965–3976.
Published: 01 October 2013
... development. Its main functional component is the trophoblast, which is derived from extra-embryonic ectoderm. Little is known about early trophoblast differentiation in the human embryo, owing to lack of a proper in vitro model system. Human embryonic stem cells (hESCs) differentiate into functional...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (2): 301–312.
Published: 15 January 2013
... neuralizing activity . Cell 77 , 283 – 295 . Itsykson P. , Ilouz N. , Turetsky T. , Goldstein R. S. , Pera M. F. , Fishbein I. , Segal M. , Reubinoff B. E. ( 2005 ). Derivation of neural precursors from human embryonic stem cells in the presence of noggin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (5): 829–841.
Published: 01 March 2012
...Kathy K. Niakan; Jinnuo Han; Roger A. Pedersen; Carlos Simon; Renee A. Reijo Pera Understanding human pre-implantation development has important implications for assisted reproductive technology (ART) and for human embryonic stem cell (hESC)-based therapies. Owing to limited resources, the cellular...
Journal Articles
Journal: Development
Development (2011) 138 (5): 861–871.
Published: 01 March 2011
.... 2011 Endoderm differentiation Human embryonic stem cells Human induced pluripotent stem cells β-Cell Pancreas Modeling embryonic development in pluripotent stem cell (PSC) differentiation cultures has proven to be the most effective approach for the efficient generation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (23): 4055–4063.
Published: 01 December 2009
...Xue-Jun Li; Xiaoqing Zhang; M. Austin Johnson; Zhi-Bo Wang; Timothy LaVaute; Su-Chun Zhang The directed differentiation of forebrain neuronal types from human embryonic stem cells (hESCs) has not been achieved. Here, we show that hESCs differentiate to telencephalic progenitors with a predominantly...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (6): 1193–1201.
Published: 15 March 2006
...Henia Darr; Yoav Mayshar; Nissim Benvenisty Human embryonic stem cells (HESCs) are pluripotent cells derived from the ICM of blastocyst stage embryos. As the factors needed for their growth are largely undefined, they are propagated on feeder cells or with conditioned media from feeder cells...
Includes: Supplementary data