... important conclusions regarding the nature of the `Hox code' in rib cage and axial skeleton development are revealed. First, axial patterning is consistently coded by the unique and redundant functions of Hox paralogous groups throughout the axial skeleton. Loss of paralogous function leads to anterior...

... domain in which neural crest cells exhibit (with a few exceptions) the same Hox code as the rhombomeres from which they originate. By altering the normal distribution of neural crest cells in the branchial arches through appropriate embryonic manipulations, we have investigated the relationships between...

... in this experimental situation with that showed by their normal fate map revealed that crest cells increase their proliferation rate and change their migratory behaviour without modifying their Hox code. * Author for correspondence 14 08 1996 © 1996 by Company of Biologists 1996 rhombomeres...

... and is expanded rostrally to the posterior half of r5 and is up-regulated in r6 ( Fig. 10G ). There is thus an enhancement of the expression of the 3 genes described. There are indications that the Hox code is responsible for generating segment identity. Since the Hox code was changed in our grafts, we...

... of related genes from the different clusters shows that subfamily members are expressed in identical rhombomeres and branchial arches. These patterns suggest a combinatorial system for specifying regional variation in the head, which we refer to as a Hox code. The Hox genes also display dynamic dorso-ventral...