... association . Genes Dev. 16 , 1518 - 1527 . 10.1101/gad.1001502 Okada , Y. , Feng , Q. , Lin , Y. , Jiang , Q. , Li , Y. , Coffield , V. M. , Su , L. , Xu , G. and Zhang , Y. ( 2005 ). hDOT1L links histone methylation to leukemogenesis . Cell 121...

...Brandon S. Carpenter; Teresa W. Lee; Caroline F. Plott; Juan D. Rodriguez; Jovan S. Brockett; Dexter A. Myrick; David J. Katz ABSTRACT Formation of a zygote is coupled with extensive epigenetic reprogramming to enable appropriate inheritance of histone methylation and prevent developmental delays...

.... This study contrasts KMT2D and UTX neural crest differentiation function as sources of variation in facial gestalt for Kabuki syndrome. KMT2D MLL4 Kabuki syndrome Histone methylation Neural crest Craniofacial Epigenetics play a vital role in facial development, as mutations in chromatin...

... led to a decrease in H3K4me3, dysregulation of crossover formation and meiotic arrest, revealing an essential role for CXXC1 in spermatogenesis and oogenesis. Meiosis Spermatogenesis Oocyte Histone methylation Chromosome Fertility CFP1 During meiosis, a diploid cell produces...

...: Conditional inactivation of the polycomb gene Eed in nephron progenitor cells results in their premature loss and prevents normal nephron differentiation beyond the S-shaped tubule stage. Epigenetics Histone methylation Kidney development Nephron Stem cell The nephrons of the metanephric...

...-establishment of DNA methylation ( Stewart et al., 2015 ; Dahl et al., 2016 ; Liu et al., 2016 ; Zhang et al., 2016 ). Histone methylation Oogenesis Pre-implantation development Transcriptional regulation Mouse Highlighted article: Oocyte-specific knockout of Setd1b in mouse disrupts...

... , R. J. , Derijck , A. A. H. A. , Perez-Burgos , L. , Kohlmaier , A. , Opravil , S. , Tachibana , M. , Shinkai , Y. , et al. ( 2003 ). Partitioning and plasticity of repressive histone methylation states in mammalian chromatin . Mol. Cell   12 , 1577 - 1589 . 10.1016...

... and H3K9me3 levels in mouse oocytes and early embryos provides insights into the dynamics of Xist repression and activation during early development and reprogramming. Xist Imprinted XCI Chromatin condensation Oogenesis Histone methylation Nuclear transfer Expression of the large non...

... Histone methylation Vascular development Vascular stability Endothelium Extracellular matrix Mmp9 Mouse Stability of the vasculature is essential for embryonic development and tissue homeostasis. Although the establishment of vascular cell fate, differentiation, and new vessel formation has...

... Genet. 2 , e51 . Schmitges F. W. , Prusty A. B. , Faty M. , Stützer A. , Lingaraju G. M. , Aiwazian J. , Sack R. , Hess D. , Li L. , Zhou S. , et al . ( 2011 ). Histone methylation by PRC2 is inhibited by active chromatin marks. Mol. Cell...

... – 5254 . Bartkowiak B. , Mackellar A. L. , Greenleaf A. L. ( 2011 ). Updating the CTD story: from tail to epic . Genet. Res. Int. 2011 , 623718 . Beisel C. , Imhof A. , Greene J. , Kremmer E. , Sauer F. ( 2002 ). Histone methylation...

... might be more complex than to simply maintain gene expression during development. Epigenetics Mouse preimplantation development Histone variant H3.3 Linker histone H1 Chromatin condensation Chromosome segregation Histone methylation Histone acetylation © 2013...

...@neuro.utah.edu ) Competing interests statement The authors declare no competing financial interests. 7 5 2013 © 2013. Published by The Company of Biologists Ltd 2013 Ezh2 Histone methylation Retina development Neurogenesis Epigenetics Wnt signaling...

... no competing financial interests. 18 9 2012 © 2012. Published by The Company of Biologists Ltd 2012 Epigenetic reprogramming Histone methylation Nuclear transfer Reprogrammed cells Oocyte extract Epigenetic reprogramming is severely deficient in both somatic cell nuclear...

... ( mmbbmc@ibmb.csic.es ) Competing interests statement 21 6 2010 © 2010. Neural development BMP pathway Epigenetic regulation Histone methylation EZH2 JMJD3 Chick neural tube During embryogenesis, multipotent neuroepithelial precursor cells originate...

... ) * These authors contributed equally to this work Competing interests statement 25 5 2010 © 2010. Bivalent chromatin Early development Histone methylation Mouse Silencing Stem cells Gene expression programmes must be tightly controlled to govern cell identity...

... and demethylation, even though histone methylation is thought to be epigenetically stable. ‡ Authors for correspondence (e-mail: bthuy@konkuk.ac.kr and teru@cdb.riken.jp ) * Present address: Department of Animal Biotechnology, College of Animal Bioscience and Biotechnology, KONKUK University, 1 Hwayang...

... of MES-mediated histone methylation and models for the roles of the MES proteins in silencing the X chromosome in the germ line. (Left)The MES-2/MES-3/MES-6 complex catalyzes di- and trimethylation of H3K27, and preferentially concentrates H3K27me3 on the X chromosome( Bender et al., 2004 ). We...

... Neuenheimer Feld 280,Heidelberg, Germany 7 2 2006 © 2006. 2006 Epigenetics Histone methylation SET domain Until recently, epigenetic mechanisms have been equated with the inheritance of heterochromatin, exemplified by DNA methylation in mammals( Wolffe and Matzke, 1999...

... effect causing severe growth retardation of neonates despite `rescue' through embryonic transcription from the paternal allele. This phenotypic effect on growth could be attributed to the asymmetric localisation of the Ezh2/Eed complex and the associated histone methylation pattern to the maternal genome...