...Aushaq B. Malla; Shannon R. Rainsford; Zachary D. Smith; Bluma J. Lesch ABSTRACT Unique chromatin remodeling factors orchestrate dramatic changes in nuclear morphology during differentiation of the mature sperm head. A crucial step in this process is histone-to-protamine exchange, which must...

... of the distinct molecular mechanisms modulating BAF chromatin binding, including its combinatory assemblies, DNA/histone modification-binding modules and post-translational modifications, as well as its interactions with proteins, RNA and lipids. This Review aims to serve as a primer for future studies to decode...

... Stewart; Kazuyuki Ohbo ABSTRACT The mammalian male germline is sustained by a pool of spermatogonial stem cells (SSCs) that can transmit both genetic and epigenetic information to offspring. However, the mechanisms underlying epigenetic transmission remain unclear. The histone methyltransferase Kmt2b...

...Shaowei Chen; Xiao Yao; Yuwen Li; Zubaida Saifudeen; Dimcho Bachvarov; Samir S. El-Dahr Histone deacetylases (HDACs) regulate a broad range of biological processes through removal of acetyl groups from histones as well as non-histone proteins. Our previous studies showed that Hdac1 and Hdac2...

... upregulation results in cells becoming primitive endoderm- and mesoderm-like ( Niwa et al., 2000 ). The PRC2 component proteins Jarid2 and Pcl2 (Mtf2) have been reported to be capable of fine-tuning the histone methyltransferase activity of PRC2, thus mitigating the repressive influence of PRC2 during...

...Chhavi Chauhan; Claudia B. Zraly; Megan Parilla; Manuel O. Diaz; Andrew K. Dingwall MLL2 and MLL3 histone lysine methyltransferases are conserved components of COMPASS-like co-activator complexes. In vertebrates, the paralogous MLL2 and MLL3 contain multiple domains required for epigenetic reading...

...Emily Clough; Woongjoon Moon; Shengxian Wang; Kathleen Smith; Tulle Hazelrigg SET domain proteins are histone lysine methyltransferases (HMTs) that play essential roles in development. Here we show for the first time that histone methylation occurs in both the germ cells and somatic cells...

...Yuki Kodama; Joel H. Rothman; Asako Sugimoto; Masayuki Yamamoto Histones play important roles not only in the structural changes of chromatin but also in regulating gene expression. Expression of histones is partly regulated post-transcriptionally by the stem-loop binding protein (SLBP)/hairpin...

...Carl Costanzi; Paula Stein; Diane M. Worrad; Richard M. Schultz; John R. Pehrson ABSTRACT MacroH2As are core histone proteins with a hybrid structure consisting of a domain that closely resembles a full-length histone H2A followed by a large nonhistone domain. We recently showed that one...

... development. Using a novel in situ approach, we present evidence that the silencing of the paternal H19 allele is progressive in the trophectodermal lineage during early mouse development and generates variegated expression patterns. The silencing process apparently involves recruitment of histone...