... establishment. Ablating pyramidal neuron SERT ( SERT PyramidΔ ) alters dendritic spine developmental trajectory in the hippocampus, and precipitates sex-biased impairments in long-term activity-dependent hippocampal synaptic plasticity and cognitive behaviors. Transcriptomic analyses identify sex-biased...

... Summary: WNT signalling and laminin 511 support the in vitro expansion of hippocampal progenitor cells, opening new avenues for studying cell type-dependent neurogenesis, synaptic transmission in the hippocampus and future cell-based therapies. Hippocampus Neurogenesis Neural progenitor cell...

...Yingqian Xia; Yizhi Zhang; Min Xu; Xiaochuan Zou; Jun Gao; Mu-Huo Ji; Guiquan Chen ABSTRACT Recent evidence has shown that presenilin enhancer 2 (Pen2; Psenen) plays an essential role in corticogenesis by regulating the switch of apical progenitors (APs) to basal progenitors (BPs). The hippocampus...

... axonal plexus of horizontal nerve fibres ( Ramón y Cajal, 1909 ; Retzius, 1893 ). Since then, this neuronal population has been named after these two neuroscientists. CRs are found in the marginal zone (MZ, the future layer I) of the neocortex, in the hippocampus and in the dentate gyrus ( Fig. 1 A,B...

.... , Tole , S. , Grove , E. and McMahon , A. P. ( 2000 ). A local Wnt-3a signal is required for development of the mammalian hippocampus . Development   127 , 457 - 467 . Leone , D. P. , Panagiotakos , G. , Heavner , W. E. , Joshi , P. , Zhao , Y. , Westphal , H...

...Suvimal Kumar Sindhu; Niveda Udaykumar; Mohd Ali Abbas Zaidi; Abhinav Soni; Jonaki Sen ABSTRACT The functions of the hippocampus are conserved between birds and mammals; however, it is not known whether similar mechanisms are responsible for its development in these two classes. In mammals...

... release. References Anders , S. , Minge , D. , Griemsmann , S. , Herde , M. K. , Steinhauser , C. and Henneberger , C. ( 2014 ). Spatial properties of astrocyte gap junction coupling in the rat hippocampus . Philos. Trans. R. Soc. Lond. B Biol. Sci.   369 , 20130600...

... to its role in neuroblast maturation and differentiation, NFIX is shown to suppress the expression of oligodendrocyte-associated genes within the adult mouse hippocampus. Adult neurogenesis Hippocampus Neural stem cell Neuroblast Oligodendrocyte Mouse NFIX is expressed during mouse...

... ( http://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Summary: The cortical hem, a telencephalic organizer that induces the hippocampus, is positionally restricted...

... as a novel transcriptional regulator in the postnatal organization and function of the hippocampus. Here, we dissect its role in DG morphogenesis by inactivating it in either granule cell progenitors or granule neurons. Loss of COUP-TFI function in progenitors leads to decreased granule cell proliferative...

... in the neocortex and hippocampus, here we reveal that NFIX-mediated activation of Insc expression promotes the timely generation of IPCs. The function of INSC has been extensively studied during D. melanogaster neurogenesis. INSC acts in D. melanogaster neuroblasts as an adaptor protein, linking two...

... neurotrophic factor (GDNF) and its receptor GFRα1 are expressed in the forebrain, the role of this system in the hippocampus remains unclear. Here, we investigated the consequences of GFRα1 deficiency for the development of hippocampal connections. Analysis of conditional Gfra1 knockout mice shows a reduction...

... . Cereb. Cortex . 10.1093/cercor/bhw040 Garthe , A. , Roeder , I. and Kempermann , G. ( 2016 ). Mice in an enriched environment learn more flexibly because of adult hippocampal neurogenesis . Hippocampus   26 , 261 - 271 . 10.1002/hipo.22520 Gebara , E. , Bonaguidi...

... of the hippocampus. Here we show that CA1, CA3 and dentate gyrus neurons each have unique responses to suppressed intrinsic excitability during circuit development. Silenced CA1 pyramidal neurons show altered spine development and synaptic transmission after postnatal day 15. By contrast, silenced CA3 pyramidal...

... disorders. The formation of excitatory and inhibitory synapses requires precise molecular control. In the hippocampus, the structure crucial for learning and memory, fibroblast growth factor 22 (FGF22) and FGF7 specifically promote excitatory or inhibitory synapse formation, respectively. Knockout of either...

..., including proliferation and migration. Telencephalic precursors acquire EGF responsiveness and upregulate EGFR expression at late stages of development. The events regulating this process and its significance are still unclear. We here show that in the developing and postnatal hippocampus (HP), growth...

... morphogenetic protein (BMP) subclass of the transforming growth factor β superfamily with a well-characterised role in limb morphogenesis, is a key regulator of the growth and elaboration of pyramidal cell dendrites in the developing hippocampus. Pyramidal cells co-express GDF5 and its preferred receptors, BMP...

... developmental and adult neurogenesis in rodents and primates. Conditional deletion of Sox4 and Sox11 , encoding two neurogenesis-related transcription factors central in this network, produces a mouse with no hippocampus, confirming the crucial role for these genes in regulating hippocampal neurogenesis...

...Felix B. Kleine Borgmann; Oliver Bracko; Sebastian Jessberger Neural stem/progenitor cells (NSPCs) generate new neurons throughout life in the mammalian hippocampus. Newborn granule cells mature over several weeks to functionally integrate into the pre-existing neural circuitry. Even though...

...Monica Venere; Young-Goo Han; Robert Bell; Jun S. Song; Arturo Alvarez-Buylla; Robert Blelloch The dentate gyrus of the hippocampus continues generating new neurons throughout life. These neurons originate from radial astrocytes within the subgranular zone (SGZ). Here, we find that Sox1, a member...