... establishment. Ablating pyramidal neuron SERT ( SERT PyramidΔ ) alters dendritic spine developmental trajectory in the hippocampus, and precipitates sex-biased impairments in long-term activity-dependent hippocampal synaptic plasticity and cognitive behaviors. Transcriptomic analyses identify sex-biased...

... Summary: WNT signalling and laminin 511 support the in vitro expansion of hippocampal progenitor cells, opening new avenues for studying cell type-dependent neurogenesis, synaptic transmission in the hippocampus and future cell-based therapies. Hippocampus Neurogenesis Neural progenitor cell...

...Yingqian Xia; Yizhi Zhang; Min Xu; Xiaochuan Zou; Jun Gao; Mu-Huo Ji; Guiquan Chen ABSTRACT Recent evidence has shown that presenilin enhancer 2 (Pen2; Psenen) plays an essential role in corticogenesis by regulating the switch of apical progenitors (APs) to basal progenitors (BPs). The hippocampus...

...–retzius cells from other neuronal types in the postnatal mouse hippocampus . eNeuro 7 , ENEURO.0516–19.2019 . 10.1523/ENEURO.0516-19.2019 Anstötz , M. , Cosgrove , K. E. , Hack , I. , Mugnaini , E. , Maccaferri , G. and Lübke , J. H. R. ( 2014 ). Morphology, input...

... multiple aspects of hippocampal development in the mouse. Hippocampus Ldb1 Lhx2 Tetramer All animal protocols were approved by the Institutional Animal Ethics Committee (Tata Institute of Fundamental Research, Mumbai, India) according to regulations devised by the Committee...

...Suvimal Kumar Sindhu; Niveda Udaykumar; Mohd Ali Abbas Zaidi; Abhinav Soni; Jonaki Sen ABSTRACT The functions of the hippocampus are conserved between birds and mammals; however, it is not known whether similar mechanisms are responsible for its development in these two classes. In mammals...

... sets the orientation of astroglial motile protrusions during polarized migration in vitro and contributes in vivo to the establishment of hippocampal astrocyte polarity during postnatal maturation. Astrocytes Connexin Polarity Development Hippocampus Mouse During early postnatal...

... in the hippocampus: from stem cells to behavior . Cell   167 , 897 - 914 . 10.1016/j.cell.2016.10.021 Hagihara , H. , Toyama , K. , Yamasaki , N. and Miyakawa , T. ( 2009 ). Dissection of hippocampal dentate gyrus from adult mouse . J. Vis. Exp.   33 , e1543 . 10.3791/1543...

... glutamatergic subtypes in the neocortex through spatiotemporal repression . Cell Rep.   3 , 931 - 945 . 10.1016/j.celrep.2013.02.023 Lee , S. M. , Tole , S. , Grove , E. and Mcmahon , A. P. ( 2000 ). A local Wnt-3a signal is required for development of the mammalian hippocampus...

... as a novel transcriptional regulator in the postnatal organization and function of the hippocampus. Here, we dissect its role in DG morphogenesis by inactivating it in either granule cell progenitors or granule neurons. Loss of COUP-TFI function in progenitors leads to decreased granule cell proliferative...

... cells during mouse forebrain development. Hippocampus Intermediate progenitor cell NFIX Mouse To investigate whether NFIs activate transcription of Insc , we first validated the microarray results from Nfix −/− E16.5 hippocampi ( Heng et al., 2014 ). Using qPCR we determined...

... neurotrophic factor (GDNF) and its receptor GFRα1 are expressed in the forebrain, the role of this system in the hippocampus remains unclear. Here, we investigated the consequences of GFRα1 deficiency for the development of hippocampal connections. Analysis of conditional Gfra1 knockout mice shows a reduction...

... that was presented at the Fusion meeting on Adult Neurogenesis, which was held in March 2016 in Cancun, Mexico. Adult neurogenesis Hippocampus Human pluripotent stem cell Neural stem cell Neurological disease Subventricular zone The human brain is complex, with millions of neuronal subtypes...

... of the hippocampus. Here we show that CA1, CA3 and dentate gyrus neurons each have unique responses to suppressed intrinsic excitability during circuit development. Silenced CA1 pyramidal neurons show altered spine development and synaptic transmission after postnatal day 15. By contrast, silenced CA3 pyramidal...

... disorders. The formation of excitatory and inhibitory synapses requires precise molecular control. In the hippocampus, the structure crucial for learning and memory, fibroblast growth factor 22 (FGF22) and FGF7 specifically promote excitatory or inhibitory synapse formation, respectively. Knockout of either...

..., including proliferation and migration. Telencephalic precursors acquire EGF responsiveness and upregulate EGFR expression at late stages of development. The events regulating this process and its significance are still unclear. We here show that in the developing and postnatal hippocampus (HP), growth...

... morphogenetic protein (BMP) subclass of the transforming growth factor β superfamily with a well-characterised role in limb morphogenesis, is a key regulator of the growth and elaboration of pyramidal cell dendrites in the developing hippocampus. Pyramidal cells co-express GDF5 and its preferred receptors, BMP...

... developmental and adult neurogenesis in rodents and primates. Conditional deletion of Sox4 and Sox11 , encoding two neurogenesis-related transcription factors central in this network, produces a mouse with no hippocampus, confirming the crucial role for these genes in regulating hippocampal neurogenesis...

...Felix B. Kleine Borgmann; Oliver Bracko; Sebastian Jessberger Neural stem/progenitor cells (NSPCs) generate new neurons throughout life in the mammalian hippocampus. Newborn granule cells mature over several weeks to functionally integrate into the pre-existing neural circuitry. Even though...

...Monica Venere; Young-Goo Han; Robert Bell; Jun S. Song; Arturo Alvarez-Buylla; Robert Blelloch The dentate gyrus of the hippocampus continues generating new neurons throughout life. These neurons originate from radial astrocytes within the subgranular zone (SGZ). Here, we find that Sox1, a member...